Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

2021 ◽  
Author(s):  
Shanyi Li ◽  
Renyi Wu ◽  
Lujing Wang ◽  
Hsiao‐Chen Dina Kuo ◽  
Davit Sargsyan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ursolic Acid ◽  
Epigenetic Reprogramming ◽  
Human Prostate ◽  
Human Prostate Cancer

Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells

2010 ◽  
Vol 20 (22) ◽  
pp. 6435-6438 ◽  
Author(s):  
Seong-Hyuk Kwon ◽  
Hye-Young Park ◽  
Jae-Yong Kim ◽  
Il-Yun Jeong ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Corni Fructus

Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells

2007 ◽  
Vol 133 (7) ◽  
pp. 493-500 ◽  
Author(s):  
E. Kassi ◽  
Z. Papoutsi ◽  
H. Pratsinis ◽  
N. Aligiannis ◽  
M. Manoussakis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Naturally Occurring

Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway

2015 ◽  
Vol 43 (07) ◽  
pp. 1471-1486 ◽  
Author(s):  
Yan Meng ◽  
Zhao-Min Lin ◽  
Nan Ge ◽  
Deng-Lu Zhang ◽  
Jie Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Mtor Pathway ◽  
Human Prostate ◽  
Tumor Xenograft ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
In Vivo Models ◽  
Induction Of Apoptosis

Ursolic acid (UA), a pentacyclic triterpenoid, is known to exert antitumor activity in breast, lung, liver and colon cancers. Nonetheless, the underlying mechanism of ursolic acid in prostate cancer cells still remains unclear. In the present study, we report the chemotherapeutic effects of ursolic acid as assessed using in vitro and in vivo models. Treatment of human prostate cancer cells (LNCaP and PC-3) with UA inhibited the proliferation and induced apoptosis in both cell lines as characterized by the increased Annexin V-binding. The induction of apoptosis by UA was associated with a decrease in the levels of Bcl-2, Bcl-xl, survivin, and activated caspase-3. Treatment with UA also inhibited the expression of phosphatidylinositol-3-kinase (PI3K), phosphorylation of Akt and mTOR signaling proteins. Further, administration of UA significantly inhibited the growth of LNCaP prostate tumor xenografts in athymic nude mice, which was associated with inhibition of cell proliferation, induction of apoptosis of tumor cells and decreased expression of PI3K downstream factors, such as p-Akt and p-mTOR in tumor xenograft tissues. Our study demonstrates that UA not only inhibits cell growth but also induces apoptosis through modulation of the PI3K/Akt/mTOR pathway in human prostate cancer cells. We suggest that UA may be a new chemotherapeutic candidate against prostate cancer.

667: Sonic Hedgehog Signaling Plays a Pivotal Role in the Vicious Cycle between Human Prostate Cancer and Normal/Benign but not Cancer Associated Human Prostate Stromal Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 224-224
Author(s):  
Katsumi Shigemura ◽  
Wen-Chin Haung ◽  
Fray F. Marshall ◽  
Haiyen E. Zhau ◽  
Leland W.K. Chung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sonic Hedgehog ◽  
Stromal Cells ◽  
Hedgehog Signaling ◽  
Pivotal Role ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Vicious Cycle ◽  
Sonic Hedgehog Signaling

629: Novel Laser Activated Gold Nanoshell Thermal Ablation of Human Prostate Cancer in Vivo

2007 ◽  
Vol 177 (4S) ◽  
pp. 210-211 ◽  
Author(s):  
Joshua M. Stern ◽  
Jennifer Stanfield ◽  
Jer-Tsang Hsieh ◽  
Jeffrey A. Cadeddu
Keyword(s):  
Prostate Cancer ◽  
Thermal Ablation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Gold Nanoshell

574: Cellular Interaction Between Prostate Cancer and Bone Stroma: Effects of Radiation on the Growth and Colonization of Human Prostate Cancer Cells in Bone

2005 ◽  
Vol 173 (4S) ◽  
pp. 157-157
Author(s):  
Tohru Miyagi ◽  
Cynthia S. Anderson ◽  
Valerie A. Odero-Marah ◽  
Peter Johnstone ◽  
Leland W.K. Chung
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Cellular Interaction ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Effects Of Radiation

1495: Elevated Expression of Tumor-Associated Macrophages is Associated with Poor Prognosis of Human Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 483-483
Author(s):  
Hitoshi Takayama ◽  
Norio Nonomura ◽  
Daizo Oka ◽  
Masahiro Shiba ◽  
Yasuyuki Arai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Poor Prognosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Tumor Associated Macrophages ◽  
Elevated Expression

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

Antimetastatic activity of halichondramide for human prostate cancer cells via modulation of PRL-3 signaling

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Shin ◽  
GD Kim ◽  
JE Jeon ◽  
J Shin ◽  
SK Lee
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Antimetastatic Activity
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