Qigong for movement disorders: A systematic review

2008 ◽  
Vol 24 (2) ◽  
pp. 301-303 ◽  
Author(s):  
Myeong Soo Lee ◽  
Edzard Ernst
2020 ◽  
Vol 91 (12) ◽  
pp. 1261-1269
Author(s):  
Birgitte Liang Chen Thomsen ◽  
Tiago Teodoro ◽  
Mark J Edwards

Functional movement disorders (FMD) are proposed to reflect a specific problem with voluntary control of movement, despite normal intent to move and an intact neural capacity for movement. In many cases, a positive diagnosis of FMD can be established on clinical grounds. However, the diagnosis remains challenging in certain scenarios, and there is a need for predictors of treatment response and long-term prognosis.In this context, we performed a systematic review of biomarkers in FMD. Eighty-six studies met our predefined criteria and were included.We found fairly reliable electroencephalography and electromyography-based diagnostic biomarkers for functional myoclonus and tremor. Promising biomarkers have also been described for functional paresis, gait and balance disorders. In contrast, there is still a lack of diagnostic biomarkers of functional dystonia and tics, where clinical diagnosis is often also more challenging. Importantly, many promising findings focus on pathophysiology and reflect group-level comparisons, but cannot differentiate on an individual basis. Some biomarkers also require access to time-consuming and resource-consuming techniques such as functional MRI.In conclusion, there are important gaps in diagnostic biomarkers in FMD in the areas of most clinical uncertainty. There is also is a lack of treatment response and prognostic biomarkers to aid in the selection of patients who would benefit from rehabilitation and other forms of treatment.


2020 ◽  
pp. 1-9
Author(s):  
Matteo Tagliapietra ◽  
Emma Frasson ◽  
Davide Cardellini ◽  
Sara Mariotto ◽  
Sergio Ferrari ◽  
...  

Background: Anti-IgLON5 disease is a rare neurodegenerative tauopathy that displays heterogeneity in clinical spectrum, disease course, cerebrospinal fluid (CSF) findings, and variable response to immunotherapy. Sleep disorders, bulbar dysfunction, and gait abnormalities are common presenting symptoms, and conventional brain MRI scanning is often unrevealing. Objective: To provide a comprehensive overview of the literature and to assess the frequency of symptoms, MRI findings, and treatment response in patients with IgLON5 autoimmunity in the serum and CSF or restricted to serum. Methods: We examined a 65-year-old woman with bulbar-onset IgLON5 disease with serum-restricted antibodies, and we also performed a systematic review of all confirmed cases reported in the English literature. Results: We identified 93 patients, included our case. Clinical data were obtained in 58 subjects, in whom the most frequent symptoms were sleep-disordered breathing, dysphagia, parasomnias, dysarthria, limb or gait ataxia, stridor or vocal cord paresis, movement disorders, and postural instability. Distinct MRI alterations were identified in 12.5% of cases, as opposed to unspecific or unremarkable changes in the remaining patients. T2-hyperintense non-enhancing signal alterations involving the hypothalamus and the brainstem tegmentum were observed only in the present case. Inflammatory CSF was found in half of the cases and serum-restricted antibodies in 4 patients. Treatment with immunosuppressant or immunomodulatory drugs led to sustained clinical response in 19/52 patients. Conclusion: Anti-IgLON5 autoimmunity should be considered in patients with sleep disorders, bulbar syndrome, autonomic involvement, and movement disorders, and high-field brain MRI can be of diagnostic help.


2009 ◽  
Vol 28 (3) ◽  
pp. 106-113 ◽  
Author(s):  
J. Puñal-Riobóo ◽  
A. Serena-Puig ◽  
L. Varela-Lema ◽  
A.M. Álvarez-Páez ◽  
A. Ruano-Ravina

2018 ◽  
Vol 33 (11) ◽  
pp. 1700-1711 ◽  
Author(s):  
Julien F. Bally ◽  
Aurélie Méneret ◽  
Emmanuel Roze ◽  
Melanie Anderson ◽  
David Grabli ◽  
...  

2011 ◽  
Vol 82 (8) ◽  
pp. 892-898 ◽  
Author(s):  
D. E. van Rooijen ◽  
E. J. Geraedts ◽  
J. Marinus ◽  
J. Jankovic ◽  
J. J. van Hilten

2011 ◽  
Vol 53 (12) ◽  
pp. 1077-1084 ◽  
Author(s):  
HILLA BEN-PAZI ◽  
SOLOMON JAWOROWSKI ◽  
RUTH S SHALEV

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