scholarly journals Novel Programming Features Help Alleviate Subthalamic Nucleus Stimulation‐Induced Side Effects

2020 ◽  
Vol 35 (12) ◽  
pp. 2261-2269
Author(s):  
Viswas Dayal ◽  
Alexis De Roquemaurel ◽  
Timothy Grover ◽  
Francisca Ferreira ◽  
Maricel Salazar ◽  
...  
Keyword(s):  
Side Effects ◽  
Subthalamic Nucleus ◽  
Subthalamic Nucleus Stimulation

Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease

2007 ◽  
Vol 106 (1) ◽  
pp. 101-110 ◽  
Author(s):  
Dominique Guehl ◽  
Roderick Edwards ◽  
Emmanuel Cuny ◽  
Pierre Burbaud ◽  
Alain Rougier ◽  
...  
Keyword(s):  
Side Effects ◽  
Parkinson Disease ◽  
Subthalamic Nucleus ◽  
Clinical Symptoms ◽  
Anterior Commissure ◽  
Posterior Commissure ◽  
Active Electrode ◽  
Residual Symptoms ◽  
Subthalamic Nucleus Stimulation ◽  
Clinical Benefits

Object The subthalamic nucleus (STN) is currently recognized as the preferred target for deep brain stimulation (DBS) in patients with Parkinson disease (PD). If there is agreement in the literature that DBS improves motor symptoms significantly, the situation is less clear with respect to the side effects of this procedure. The goal of this study was to correlate the coordinate values of active electrode contacts with the amplitude of residual clinical symptoms and side effects using a mathematical approach. Methods In this study the investigators examined a cohort of 41 patients with PD who received clinical benefits from DBS after stimulating electrodes had been implanted bilaterally into the STN. The combined scores of residual clinical symptoms plus side effects, including speech disturbance, postural instability, and weight gain, were fitted by using either inverted ellipsoidal exponentials or smooth splines. These analyses showed evidence of lower combined scores for stimulating contacts at an x coordinate approximately 12.0 to 12.3 mm lateral to the anterior commissure–posterior commissure (AC–PC) line and at a z coordinate approximately 3.1 to 3.3 mm under the AC–PC line. There was insufficient evidence for a preferred y coordinate location. Conclusions The authors propose a “best” therapeutic ellipse area that is centered at an x, z location of 12.5 mm, −3.3 mm and characterized by an extension of 1.85 mm in the x direction and 2.22 mm in the z direction. Therapeutic electrode contacts located within this area are well correlated with the lowest occurrence of residual symptoms and the lowest occurrence of side effects independent of STN anatomical considerations. The lack of a significant result in the y direction remains to be explored further.

Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease

2013 ◽  
Vol 250 ◽  
pp. 221-227 ◽  
Author(s):  
Bogdan Neagu ◽  
Eric Tsang ◽  
Filomena Mazzella ◽  
Clement Hamani ◽  
Elena Moro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Evoked Potentials ◽  
Subthalamic Nucleus ◽  
Pedunculopontine Nucleus ◽  
Subthalamic Nucleus Stimulation

Impact of subthalamic nucleus stimulation did not differ on young-onset and older-onset Parkinson's disease: A three-year follow up

2019 ◽  
Vol 705 ◽  
pp. 99-105
Author(s):  
Junmei Zhang ◽  
Ge Jia ◽  
Zhuanyi Yang ◽  
Dingyang Liu ◽  
Yonghong Hou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Young Onset ◽  
Subthalamic Nucleus Stimulation

Complex repetitive behavior: Punding after bilateral subthalamic nucleus stimulation in Parkinson's disease

2010 ◽  
Vol 16 (6) ◽  
pp. 376-380 ◽  
Author(s):  
Stefano Pallanti ◽  
Silvia Bernardi ◽  
Laura Maria Raglione ◽  
Paolo Marini ◽  
Franco Ammannati ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Repetitive Behavior ◽  
Subthalamic Nucleus Stimulation

scholarly journals Effects of Subthalamic Nucleus Stimulation on Emotional Prosody Comprehension in Parkinson's Disease

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e19140 ◽  
Author(s):  
Carolin Brück ◽  
Dirk Wildgruber ◽  
Benjamin Kreifelts ◽  
Rejko Krüger ◽  
Tobias Wächter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Emotional Prosody ◽  
Subthalamic Nucleus Stimulation

Results of chronic subthalamic nucleus stimulation for Parkinson’s disease: a 1-year follow-up study

2002 ◽  
Vol 57 (5) ◽  
pp. 306-311 ◽  
Author(s):  
J Vesper ◽  
F Klostermann ◽  
F Stockhammer ◽  
Th Funk ◽  
M Brock
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Follow Up Study ◽  
Subthalamic Nucleus Stimulation
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