scholarly journals PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach

2008 ◽  
Vol 59 (4) ◽  
pp. 679-685 ◽  
Author(s):  
Wenlian Zhu ◽  
Baasil Okollie ◽  
Zaver M. Bhujwalla ◽  
Dmitri Artemov
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Pamam Dendrimer ◽  
Her 2

Molecular MR Imaging of CD44 in Breast Cancer with Hyaluronan-Based Contrast Agents

2009 ◽  
Author(s):  
Dmitri Artemov ◽  
Wenlian Zhu
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agents

Contrast agents for MR imaging of the liver: a clinical overview

1997 ◽  
Vol 7 (4) ◽  
pp. 507-513 ◽  
Author(s):  
A.-E. Mahfouz ◽  
B. Hamm ◽  
M. Taupitz
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Clinical Overview

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

Enhancement pattern of hepatocellular adenoma (HCA) on MR imaging performed with Gd-EOB-DTPA versus other Gd-based contrast agents (GBCAs): An intraindividual comparison

2019 ◽  
Vol 119 ◽  
pp. 108633 ◽  
Author(s):  
Roberto Cannella ◽  
Giuseppe Brancatelli ◽  
Balasubramanya Rangaswamy ◽  
Marta I. Minervini ◽  
Amir A. Borhani ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Hepatocellular Adenoma ◽  
Enhancement Pattern ◽  
Intraindividual Comparison

Intraluminal contrast agents for MR imaging of the abdomen and pelvis

1994 ◽  
Vol 4 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Tammo H. Pels Rijcken ◽  
Michael A. Davis ◽  
Pablo R. Ros
Keyword(s):  
Mr Imaging ◽  
Contrast Agents

scholarly journals Myocardial paramagnetic contrast agents for MR imaging

1988 ◽  
Vol 151 (5) ◽  
pp. 865-871 ◽  
Author(s):  
JJ Brown ◽  
CB Higgins
Keyword(s):  
Mr Imaging ◽  
Contrast Agents

Intrathecal administration of nitroxides as potential contrast agents for MR imaging.

Radiology ◽  
1987 ◽  
Vol 163 (1) ◽  
pp. 239-243 ◽  
Author(s):  
G M Rosen ◽  
L K Griffeth ◽  
M A Brown ◽  
B P Drayer
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Intrathecal Administration

Cellular MR Imaging of the Liver Using Contrast Agents

2007 ◽  
pp. 247-257
Author(s):  
N. Cem Balci ◽  
Sukru Mehmet Erturk
Keyword(s):  
Mr Imaging ◽  
Contrast Agents

scholarly journals Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1422 ◽  
Author(s):  
Marcinkowska ◽  
Stanczyk ◽  
Janaszewska ◽  
Gajek ◽  
Ksiezak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Pamam Dendrimer ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Action ◽  
Her 2 ◽  
The Impact ◽  
Dendrimer Conjugates

Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently. For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or paclitaxel and monoclonal antibody trastuzumab, specifically targeted to cells which overexpressed HER-2. For this purpose, the impact on the level of reactive oxygen species, the mitochondrial membrane potential, cell cycle distribution and the activity of caspases-3/7, -8 and -9 of PAMAM-doc-trastuzumab and PAMAM-ptx-trastuzumab conjugates was determined and compared with free docetaxel and paclitaxel toward HER-2-positive (SKBR-3) and negative (MCF-7) human breast cancer cell lines. Moreover, apoptosis and necrosis were studied using flow cytometry and confocal microscopy, respectively. Our studies show the complexity of the potential mechanism of cytotoxic action of PAMAM-drug-trastuzumab conjugates that should be sought as a resultant of oxidative stress, mitochondrial activation of the caspase cascade and the HER-2 receptor blockade.

Contrast Agents for Liver MR Imaging

2003 ◽  
pp. 19-45
Author(s):  
Günther Schneider ◽  
Luigi Grazioli ◽  
Sanjay Saini
Keyword(s):  
Mr Imaging ◽  
Contrast Agents
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