Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

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LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

Biomaterials Science ◽

10.1039/c5bm00508f ◽

2016 ◽

Vol 4 (3) ◽

pp. 474-482 ◽

Cited By ~ 24

Author(s):

Ling Ding ◽

Yong Hu ◽

Yu Luo ◽

Jianzhi Zhu ◽

Yilun Wu ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Colloidal Stability ◽

Coprecipitation Method ◽

Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

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PLGA Hollow Microbubbles Loaded with Iron Oxide Nanoparticles and Doxorubicin for Dual-mode US/MR Imaging and Drug Delivery

Current Nanoscience ◽

10.2174/1573413710666140429223927 ◽

2014 ◽

Vol 10 (4) ◽

pp. 543-552 ◽

Cited By ~ 7

Author(s):

Weina Liu ◽

Shihui Wen ◽

Luying Jiang ◽

Xiao An ◽

Mengxin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Dual Mode

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Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Langmuir ◽

10.1021/acs.langmuir.9b00736 ◽

2019 ◽

Vol 35 (29) ◽

pp. 9474-9482 ◽

Cited By ~ 9

Author(s):

Chichong Lu ◽

Pingli Dong ◽

Lei Pi ◽

Zhijie Wang ◽

Huanxiang Yuan ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Manganese Oxide ◽

Iron Oxide Nanoparticles ◽

Phosphonic Acid ◽

Synergistic Effects ◽

Oxide Nanoparticles ◽

Dual Mode

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Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization

International Journal of Nanomedicine ◽

10.2147/ijn.s38702 ◽

2013 ◽

pp. 767 ◽

Cited By ~ 3

Author(s):

Matthias Taupitz ◽

Wagner ◽

Schnorr ◽

Ludwig ◽

Stangl ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Plaque Characterization ◽

Contrast Enhanced

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The Effect of pH and Viscosity on Magnetophoretic Separation of Iron Oxide Nanoparticles

Magnetochemistry ◽

10.3390/magnetochemistry7060080 ◽

2021 ◽

Vol 7 (6) ◽

pp. 80

Author(s):

Leonie Wittmann ◽

Chiara Turrina ◽

Sebastian P. Schwaminger

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Colloidal Stability ◽

Downstream Processing ◽

Physicochemical Characteristics ◽

Particle Migration ◽

Aggregation Behavior ◽

Oxide Nanoparticles ◽

Separation Processes ◽

Effect Of Ph

Magnetic nanoparticles (MNPs) are used for magnetophoresis-based separation processes in various biomedical and engineering applications. Essential requirements are the colloidal stability of the MNPs and the ability to be separated even in low magnetic field gradients. Bare iron oxide nanoparticles (BIONs) with a diameter of 9.2 nm are synthesized via coprecipitation, exhibiting a high saturation magnetization of 70.84 Am2 kg−1 and no remanence. In our study, zeta potential, dynamic light scattering (DLS), and sedimentation analysis show that the aggregation behavior of BIONs is influenced by pH and viscosity. Small aggregate clusters are formed with either low or high pH values or increased viscosity. Regarding magnetophoresis-based separation, a higher viscosity leads to lower magnetophoretic velocities, similar to how small aggregates do. Additionally, cooperative magnetophoresis, the joint motion of strongly interacting particles, affects the separation of the BIONs, too. Our study emphasizes the effect of pH and viscosity on the physicochemical characteristics of MNPs, resulting in different aggregation behavior. Particularly, for high viscous working media in downstream processing and medicine, respectively, the viscosity should be taken into account, as it will affect particle migration.

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Magnetic Properties and SAR for Gadolinium-Doped Iron Oxide Nanoparticles Prepared by Hydrothermal Method

Crystals ◽

10.3390/cryst11101153 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1153

Author(s):

Heba Kahil ◽

Ahmed Faramawy ◽

Hesham El-Sayed ◽

Adel Abdel-Sattar

Keyword(s):

Iron Oxide ◽

Hydrothermal Method ◽

Iron Oxide Nanoparticles ◽

Photoelectron Spectroscopy ◽

Pure Iron ◽

Xrd Analysis ◽

Solubility Limit ◽

Great Promise ◽

Oxide Nanoparticles ◽

Pure Iron Oxide

This study is an attempt to produce gadolinium-doped iron oxide nanoparticles for the purpose of utilization in magnetic fluid hyperthermia (MFH). Six gadolinium-doped iron oxide samples with varying gadolinium contents ( were prepared using the hydrothermal method and high vapor pressure to incorporate gadolinium ions in the iron oxide structure. The samples were indexed as , with varying from 0.0 to 0.1. The results reveal that gadolinium ions have a low solubility limit in the iron oxide lattice (x = 0.04). The addition of gadolinium caused distortion in the produced maghemite phase and formation of other phases. Based on X-ray diffraction (XRD) analysis and photoelectron spectroscopy (XPS), it was observed that gadolinium mostly crystalized as gadolinium hydroxide, for gadolinium concentrations above the solubility limit. The measured magnetization values are consistent with the formed phases. The saturation magnetization values for all gadolinium-doped samples are lower than the undoped sample. The specific absorption rate (SAR) for the pure iron oxide samples was measured. Sample GdIO/0.04, pure iron oxide doped with gadolinium, showed the highest potential to produce heat at a frequency of 198 kHz. Therefore, the sample is considered to hold great promise as an MFH agent.

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Preparation and Characterization of Polyethylene Glycol Coating Iron Oxide Nanoparticles for Curcumin Delivery

Asian Journal of Chemistry ◽

10.14233/ajchem.2019.21941 ◽

2019 ◽

Vol 31 (8) ◽

pp. 1719-1723

Author(s):

Nguyen Thi Thanh Thuy ◽

Le Duc Anh ◽

Nguyen Huu Tri ◽

Cu Van Hoang ◽

Nguyen Anh Nhut

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Sonication Time ◽

X Ray Diffraction ◽

Target Drug Delivery ◽

Target Drug ◽

Fe3o4 Nps ◽

Average Size

The PEG-coated iron oxide nanoparticles (Fe3O4 NPs-PEG) was synthesized by coprecipitation and ultrasonication method. X-ray diffraction results exhibited that the average size of Fe3O4 NPs-PEG was 19.10 nm, which was further confirmed in TEM imaging. In addition, sonication time and curcumin concentration were studied to evaluate the efficiency of loading curcumin onto Fe3O4 NPs-PEG. Further, statistical optimization using response surface methodology (RSM) has shown curcumin concentration (0,01% w/v) and sonication time (21 min) for maximal curcumin loading (0.37 mg/g). Along with the magnetization studies, the immobilization of curcumin onto the Fe3O4 NPs-PEG was characterized by UV, FTIR and SEM. The results showed that the curcumin loaded PEG coated iron oxide nanoparticles could potentially be used for magnetically target drug delivery.

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