Double-wave-vector diffusion-weighted imaging reveals microscopic diffusion anisotropy in the living human brain

2012 ◽  
Vol 69 (4) ◽  
pp. 1072-1082 ◽  
Author(s):  
Marco Lawrenz ◽  
Jürgen Finsterbusch
2003 ◽  
Vol 21 (10) ◽  
pp. 1151-1157 ◽  
Author(s):  
F Fasano ◽  
S Capuani ◽  
G.E Hagberg ◽  
T Branca ◽  
I Indovina ◽  
...  

NeuroImage ◽  
2009 ◽  
Vol 46 (3) ◽  
pp. 775-785 ◽  
Author(s):  
Jennifer A. McNab ◽  
Saâd Jbabdi ◽  
Sean C.L. Deoni ◽  
Gwenaëlle Douaud ◽  
Timothy E.J. Behrens ◽  
...  

2012 ◽  
Vol 33 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Patrick W Hales ◽  
Chris A Clark

A number of two-compartment models have been developed for the analysis of arterial spin labeling (ASL) data, from which both cerebral blood flow ( CBF) and capillary permeability-surface product ( PS) can be estimated. To derive values of PS, the volume fraction of the ASL signal arising from the intravascular space ( vbw) must be known a priori. We examined the use of diffusion-weighted imaging (DWI) and subsequent analysis using the intravoxel incoherent motion model to determine vbw in the human brain. These data were then used in a two-compartment ASL model to estimate PS. Imaging was performed in 10 healthy adult subjects, and repeated in five subjects to test reproducibility. In gray matter (excluding large arteries), mean voxel-wise vbw was 2.3 ± 0.2 mL blood/100 g tissue (all subjects mean ± s.d.), and CBF and PS were 44 ± 5 and 108 ± 2 mL per 100 g per minute, respectively. After spatial smoothing using a 6-mm full width at half maximum Gaussian kernel, the coefficient of repeatability of CBF, vbw and PS were 8 mL per 100 g per minute, 0.4 mL blood/100 g tissue, and 13 mL per 100 g per minute, respectively. Our results show that the combined use of ASL and DWI can provide a new, noninvasive methodology for estimating vbw and PS directly, with reproducibility that is sufficient for clinical use.


2016 ◽  
Vol 51 (7) ◽  
pp. 435-439 ◽  
Author(s):  
Ikuhiro Kida ◽  
Takashi Ueguchi ◽  
Yuichiro Matsuoka ◽  
Kun Zhou ◽  
Alto Stemmer ◽  
...  

2019 ◽  
Vol 32 (4) ◽  
pp. e4056 ◽  
Author(s):  
Samantha J. Holdsworth ◽  
Rafael O'Halloran ◽  
Kawin Setsompop

Author(s):  
J Yamamura ◽  
G Salomon ◽  
J Graessner ◽  
A Hohenstein ◽  
M Graefen ◽  
...  

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