Endothelin ETB Receptors Are Involved in the Relaxation to the Pig Urinary Bladder neck

2012 ◽  
Vol 31 (5) ◽  
pp. 688-694 ◽  
Author(s):  
José Luis Arteaga ◽  
Luis M. Orensanz ◽  
María Pilar Martínez ◽  
María Victoria Barahona ◽  
Ana Martínez-Sáenz ◽  
...  
Keyword(s):  
2017 ◽  
Vol 3 (2) ◽  
pp. 205511691773364
Author(s):  
Matias Ruiz-Drebing ◽  
Fui Yap ◽  
Mayank Seth ◽  
Ruth Dennis ◽  
Elisabet Dominguez

Case summary A 33-month-old, spayed female domestic shorthair cat was referred to the Animal Health Trust for the investigation of urinary incontinence and straining to urinate. A membrane-like structure was detected in the bladder neck, which caused partial obstruction of the urinary bladder. A combination of different imaging techniques, including ultrasonography, radiography, CT and fluoroscopy, was essential in the diagnosis, surgical planning and treatment of this intravesicular stricture. During retrograde vaginourethrocystogram, unexpected subcapsular accumulation of contrast medium was seen around both kidneys on radiographs and confirmed with CT. Three different treatments were performed, including surgical debridement, balloon dilatation and placement of a self-expanding metallic stent across the stricture. Histopathology of the membrane was unable to differentiate whether the lesion was congenital or acquired. No urinary incontinence was observed 5 months after placement of the metallic stent. Relevance and novel information This is the first reported case using fluoroscopic-guided balloon dilatation of the bladder neck for the treatment of a bladder neck stricture. Presence of renal subcapsular contrast medium secondary to a retrograde vaginourethrocystogram due to partial obstruction at the bladder neck in a cat has not been previously described.


1999 ◽  
Vol 15 (3-4) ◽  
pp. 290-293 ◽  
Author(s):  
V. Bhatnagar ◽  
R. Lal ◽  
S. Agarwala ◽  
D. K. Mitra

2013 ◽  
Vol 3 (5) ◽  
pp. 45 ◽  
Author(s):  
C-H. Chen ◽  
Alexander H. Boag ◽  
Darren T. Beiko ◽  
Robert Siemens ◽  
Alison Froese ◽  
...  

A 64-year-old man presented with gross painless hematuria.Cystoscopy revealed a submucosal bladder neck mass coveredby normal urothelium. During transurethral resection, the patientdeveloped hemodynamic crisis including sinus bradycardia.Histopathologic examination revealed a primary bladder compositeparaganglioma-ganglioneuroma (CPG). The patient underwentpartial cystectomy and is symptom-free after one year. BladderCPGs are extremely rare neoplasms that may result in lifethreateningcatecholamine secretion, especially during tumourmanipulation. These tumours require complete surgical excisionand should be included in the differential diagnosis of any solitarybladder mass covered by normal urothelium, especially whenthere is a history of hypertension or micturition attacks.


2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Kelven Weijing Chen ◽  
Fiona Mei Wen Wu ◽  
Victor Kwan Min Lee ◽  
Kesavan Esuvaranathan

Embryonal rhabdomyosarcoma (ERMS) of the adult urinary bladder is a rare malignant tumour. Inflammatory myofibroblastic tumour (IMT) of the bladder is a benign genitourinary tumour that may appear variable histologically but usually lacks unequivocal malignant traits. Techniques like flow cytometry and immunohistochemistry may be used to differentiate these two tumours. Our patient, a 46-year-old male, had rapidly recurring lower urinary tract symptoms after two transurethral resections of the prostate. He subsequently underwent a transvesical prostatectomy which showed IMT on histology. However, his symptoms did not resolve and an open resection done at our institution revealed a 6 cm tumour arising from the right bladder neck. This time, histology was ERMS with diffuse anaplasia of the bladder. Rapid recurrence of urinary symptoms with prostate regrowth after surgery is unusual. Differential diagnoses of uncommon bladder malignancies should be considered if there is an inconsistent clinical course as treatment approaches are different.


2017 ◽  
Vol 2 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Daniel Schnelle ◽  
Frank-Jürgen Weinreich ◽  
Janek Kibat ◽  
Marc A. Reymond

AbstractBackgroundDevelopment of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) requires adequate preclinical models.MethodsThe model should be easy to use, reproducible and cost-effective. It should have a volume similar to the human abdominal cavity, and an oval shape. The inner surface should be lined with serosa. The model should allow pharmacological and biological analysis, including histology. No living animals should be used.ResultsThe fresh urinary bladder is explanted from an adult bovine in the slaughterhouse. A 4-cm incision is performed into the bladder neck. The bladder can be inverted through the incision, which allows exposition of the serosa on its inner side. A balloon trocar is inserted through the incision and a ligature placed, ensuring full tightness. The therapeutic capnoperitoneum is installed. The bovine bladder has a volume somewhat smaller (2–3 L) than the human abdominal cavity (3–5 L). Costs are minimal. There is no significant bacteriological contamination. Manipulation is simple.ConclusionsThe (inverted) bovine urinary bladder is an innovative and versatile ex vivo model for optimizing drug delivery with therapeutic aerosols both onto the mucosa or the serosa. This model can be used for pharmaceutical Quality-by-Design approaches and will replace a large number of experiments in the animal.


2006 ◽  
Vol 149 (1) ◽  
pp. 100-109 ◽  
Author(s):  
M Hernández ◽  
M V Barahona ◽  
P Recio ◽  
S Benedito ◽  
A C Martínez ◽  
...  

2011 ◽  
Vol 31 (1) ◽  
pp. 156-161 ◽  
Author(s):  
José Luis Arteaga ◽  
Luis M. Orensanz ◽  
María Pilar Martínez ◽  
María Victoria Barahona ◽  
Paz Recio ◽  
...  

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