Is pelvic organ prolapse associated with altered microcirculation of the vaginal wall?

2015 ◽  
Vol 35 (7) ◽  
pp. 764-770 ◽  
Author(s):  
M.A. Weber ◽  
D.M.J. Milstein ◽  
C. Ince ◽  
J.P.W.R. Roovers
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Vaginal Wall

Tissue Composition of the Vaginal Wall in Women with Pelvic Organ Prolapse

2013 ◽  
Vol 75 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Aukje M. Meijerink ◽  
Reinier H. van Rijssel ◽  
Paul J.Q. van der Linden
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Tissue Composition

scholarly journals Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

2016 ◽  
Vol 60 (1) ◽  
Author(s):  
A. Vetuschi ◽  
A. D'Alfonso ◽  
R. Sferra ◽  
D. Zanelli ◽  
S. Pompili ◽  
...  
Keyword(s):  
Risk Factors ◽  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Smooth Muscle Cells ◽  
Muscularis Propria ◽  
Muscle Cells ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Collagen Iii

<p>The objective<strong> </strong>of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient selection was carried on the basis of specific criteria and all of the patients involved in the study presented one or more of the recognized POP risk factors. Samples were taken from POP patients during vaginal plastic surgery following  colpohysterectomy, and from control patients during closure of the posterior fornix following hysterectomy. Samples were processed for histological and  immunohistochemical analyses for Collagen I and Collagen III, α-Smooth Muscle Actin (α-SMA), Platelet-Derived-Growth-Factor (PDGF), matrix metalloproteinase 3 (MMP3), Caspase3. Immunofluorescence analyses for Collagen I and III and PDGF were also carried out. In prolapsed specimens our results show a disorganization of smooth muscle cells that appeared to have been displaced by an increased collagen III deposition resulting in rearrangement of the muscularis propria architecture. These findings suggest that the increase in the expression of collagen fibers in muscularis could probably due to a phenotypic switch resulting in the dedifferentiation of smooth muscle cells into myofibroblasts. These alterations could be responsible for the compromising of the dynamic functionality of the pelvic floor.</p><p><strong> </strong></p>

Expression of Mitochondrial Respiratory Chain Complexes in the Vaginal Wall in Postmenopausal Women with Pelvic Organ Prolapse

2017 ◽  
Vol 83 (5) ◽  
pp. 487-492 ◽  
Author(s):  
Ivana Alujević Jakus ◽  
Dora Jakus ◽  
Jasna Marinović ◽  
Marija Ćavar ◽  
Ivana Banić ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Postmenopausal Women ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Respiratory Chain Complexes ◽  
Chain Complexes ◽  
Mitochondrial Respiratory

Detection of oncological diseases in patients with pelvic organ prolapse. Case report

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 193-197
Author(s):  
Dmitrii V. Baibuz ◽  
Oleg L. Molchanov ◽  
Zhanna V. Glushchenko ◽  
Yanina A. Lebedeva ◽  
Sergei V. Utkin ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Preoperative Diagnosis ◽  
Abdominal Cavity ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Benign Disease ◽  
Pelvic Tumor ◽  
Planning Treatment ◽  
Oncological Diseases ◽  
Anterior Posterior

Pelvic organ prolapse is a common benign disease among women that is characterized by an isolated or combined descent of the anterior, posterior vaginal wall, uterus, and vaginal dome after hysterectomy. Given the fact that most of the operations are performed among middle-aged and elderly patients, the probability of detecting previously undiagnosed tumor of the abdominal cavity and pelvic region increases, which may be due to the limited volume of basic preoperative diagnosis. The purpose of our report is to draw the attention of clinicians to the problem of insufficient examination of women when planning treatment of pelvic organ prolapse on the example of our experience in managing a patient with this pathology in combination with pelvic tumor.

Computational Modeling of Anterior and Posterior Pelvic Organ Prolapse (POP)

2016 ◽  
Author(s):  
Arnab Chanda ◽  
Vinu Unnikrishnan ◽  
Holly E. Richter ◽  
Mark E. Lockhart
Keyword(s):  
Pelvic Organ Prolapse ◽  
Urinary Bladder ◽  
High Stress ◽  
Significant Proportion ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Vaginal Tissue ◽  
Bladder Filling ◽  
Vaginal Length ◽  
Vaginal Canal

Pelvic Organ Prolapse (POP) is a condition of the female pelvic system suffered by a significant proportion of women in the U.S. and more across the globe, every year. POP is caused by the weakening of the pelvic floor muscles and musculo-connective tissues due to child birth, menopause and morbid obesity. Prolapse of the pelvic organs namely the urinary bladder, uterus, and rectum into the vaginal canal can cause vaginal discomfort, strained urination or defecation, and sexual dysfunction. To date, success rates of native tissue POP surgeries vary from 50–70% depending on the definition of cure and time-point of assessment. A better understanding of the mechanics of prolapse may lead to improvement in surgical outcomes. In the current work, the mechanics of progression of anterior and posterior vaginal prolapse were modeled to understand the effect of bladder fill and posterior vaginal stresses using computational approaches. A realistic and full-scale female pelvic system model, comprised of the urinary bladder, vaginal canal, uterus, rectum, and fascial connective tissue, was developed using image segmentation methods. All of the relevant loads and boundary conditions were applied based on a comprehensive study of the anatomy and functional morphology of the female pelvis. Hyperelastic material models were adopted to characterize all pelvic tissues, and a non-linear analysis was invoked. In the first set of simulations, a realistic bladder filling and vaginal tissue stiffening in prolapse were modeled and their effects on the anterior vaginal wall (AVW) were estimated in terms of the induced stresses, strains and displacements. The degree of bladder filling was found to be a strong indicator of stress build-up on the AVW. Also, vaginal tissue stiffening was found to increase the size of the high stress zone on the AVW. The second simulation consisted of modeling the different degrees of posterior vaginal wall (PVW) prolapse, in the presence of an average abdominal pressure. The vaginal length was segmented into four sections to study the localized stresses and strains. Also, a clinically well-known phenomena known as the kneeling effect was observed with the PVW in which the vaginal wall displaces away from the rectum and downward towards the vaginal hiatus. All of these results have relevant clinical implications and may provide important perspective for better understanding the mechanics of POP pathophysiology.

scholarly journals Relationship between intra-abdominal pressure and vaginal wall movements during Valsalva in women with and without pelvic organ prolapse: technique development and early observations

2014 ◽  
Vol 25 (7) ◽  
pp. 873-881 ◽  
Author(s):  
D. M. Spahlinger ◽  
L. Newcomb ◽  
J. A. Ashton-Miller ◽  
J. O. L. DeLancey ◽  
Luyun Chen
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Abdominal Pressure ◽  
Technique Development

Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse

2002 ◽  
Vol 187 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Muriel K. Boreham ◽  
Clifford Y. Wai ◽  
Rodney T. Miller ◽  
Joseph I. Schaffer ◽  
R.Ann Word
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Morphometric Analysis ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall

Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall

2015 ◽  
Vol 35 (7) ◽  
pp. 726-732 ◽  
Author(s):  
S. H. Rhee ◽  
P. Zhang ◽  
K. Hunter ◽  
S. T. Mama ◽  
R. Caraballo ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Rho Kinase ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Signalling Pathway ◽  
Sphingosine 1 Phosphate

Defecatory dysfunction and fecal incontinence in women with or without posterior vaginal wall prolapse as measured by pelvic organ prolapse quantification (POP-Q)

2017 ◽  
Vol 214 ◽  
pp. 50-55 ◽  
Author(s):  
Kathiane Lustosa Augusto ◽  
Leonardo Robson Pinheiro Sobreira Bezerra ◽  
Sthela Maria Murad-Regadas ◽  
José Ananias Vasconcelos Neto ◽  
Camila Teixeira Moreira Vasconcelos ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Fecal Incontinence ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Posterior Vaginal Wall ◽  
Pelvic Organ Prolapse Quantification ◽  
Posterior Vaginal Wall Prolapse ◽  
Defecatory Dysfunction
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