A semi‐LASER, single‐voxel spectroscopic sequence with a minimal echo time of 20.1 ms in the human brain at 3 T

2020 ◽  
Vol 33 (9) ◽  
Author(s):  
Karl Landheer ◽  
Martin Gajdošík ◽  
Christoph Juchem
Keyword(s):  
Human Brain ◽  
Single Voxel ◽  
Echo Time

scholarly journals Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T

2019 ◽  
Vol 30 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Helen Maghsudi ◽  
Birte Schmitz ◽  
Andrew A. Maudsley ◽  
Sulaiman Sheriff ◽  
Paul Bronzlik ◽  
...  
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Whole Brain ◽  
Single Voxel ◽  
Metabolite Concentrations ◽  
Mr Spectroscopic Imaging

scholarly journals N-acetyl-aspartyl-glutamate detection in the human brain at 7 Tesla by echo time optimization and improved Wiener filtering

2013 ◽  
Vol 72 (4) ◽  
pp. 903-912 ◽  
Author(s):  
Li An ◽  
Shizhe Li ◽  
Emily T. Wood ◽  
Daniel S. Reich ◽  
Jun Shen
Keyword(s):  
Human Brain ◽  
Wiener Filtering ◽  
7 Tesla ◽  
Time Optimization ◽  
Echo Time

Single-voxel proton MRS of the human brain at 1.5T and 3.0T

2001 ◽  
Vol 45 (5) ◽  
pp. 765-769 ◽  
Author(s):  
Peter B. Barker ◽  
David O. Hearshen ◽  
Michael D. Boska
Keyword(s):  
Human Brain ◽  
Proton Mrs ◽  
Single Voxel

scholarly journals Very short echo time proton MR spectroscopy of human brain with a standard transmit/receive surface coil

2000 ◽  
Vol 44 (6) ◽  
pp. 964-967 ◽  
Author(s):  
V. Mlyn�rik ◽  
S. Gruber ◽  
Z. Star?uk ◽  
Z. Star?uk ◽  
E. Moser
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy ◽  
Surface Coil ◽  
Proton Mr Spectroscopy ◽  
Echo Time ◽  
Short Echo Time

scholarly journals On the Utility of Short Echo Time (TE) Single Voxel 1H–MRS in Non–Invasive Detection of 2–Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147794 ◽  
Author(s):  
Hwon Heo ◽  
Sungjin Kim ◽  
Hyeong Hun Lee ◽  
Hye Rim Cho ◽  
Wen Jun Xu ◽  
...  
Keyword(s):  
Animal Models ◽  
1H Mrs ◽  
Non Invasive ◽  
Single Voxel ◽  
Echo Time ◽  
Potential Improvement ◽  
Short Echo Time

scholarly journals Prevalence of white matter pathways coming into a single diffusion MRI voxel orientation: the bottleneck issue in tractography

2021 ◽  
Author(s):  
Kurt Schilling ◽  
Chantal M.W. Tax ◽  
Francois M.W. Rheault ◽  
Bennett A Landman ◽  
Adam W Anderson ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Diffusion Mri ◽  
Brain Connectivity ◽  
False Negative ◽  
Fiber Tractography ◽  
Single Voxel ◽  
Ill Posed ◽  
Pass Through

Characterizing and understanding the limitations of diffusion MRI fiber tractography is a prerequisite for methodological advances and innovations which will allow these techniques to accurately map the connections of the human brain. The so-called "crossing fiber problem" has received tremendous attention and has continuously triggered the community to develop novel approaches for disentangling distinctly oriented fiber populations. Perhaps an even greater challenge occurs when multiple white matter bundles converge within a single voxel, or throughout a single brain region, and share the same parallel orientation, before diverging and continuing towards their final cortical or sub-cortical terminations. These so-called "bottleneck" regions contribute to the ill-posed nature of the tractography process, and lead to both false positive and false negative estimated connections. Yet, as opposed to the extent of crossing fibers, a thorough characterization of bottleneck regions has not been performed. The aim of this study is to quantify the prevalence of bottleneck regions. To do this, we use diffusion tractography to segment known white matter bundles of the brain, and assign each bundle to voxels they pass through and to specific orientations within those voxels (i.e. fixels). We demonstrate that bottlenecks occur in greater than 50-70% of fixels in the white matter of the human brain. We find that all projection, association, and commissural fibers contribute to, and are affected by, this phenomenon, and show that even regions traditionally considered "single fiber voxels" often contain multiple fiber populations. Together, this study shows that a majority of white matter presents bottlenecks for tractography which may lead to incorrect or erroneous estimates of brain connectivity or quantitative tractography (i.e., tractometry), and underscores the need for a paradigm shift in the process of tractography and bundle segmentation for studying the fiber pathways of the human brain.

scholarly journals Inversion recovery zero echo time (IR-ZTE) imaging for direct myelin detection in human brain: a feasibility study

2020 ◽  
Vol 10 (5) ◽  
pp. 895-906
Author(s):  
Hyungseok Jang ◽  
Michael Carl ◽  
Yajun Ma ◽  
Adam C. Searleman ◽  
Saeed Jerban ◽  
...  
Keyword(s):  
Human Brain ◽  
Feasibility Study ◽  
Inversion Recovery ◽  
Echo Time
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