Selective 5HT3 antagonists and sensory processing: a systematic review

Ondansetron is a selective serotonin (5HT3) receptor antagonist that is under evaluation as an adjunctive treatment for schizophrenia, and a novel treatment for hallucinations in Parkinson’s disease. Ondansetron reverses sensory gating deficits and improves visuoperceptual processing in animal models of psychosis, but it is unclear to what extent preclinical findings have been replicated in humans. We systematically reviewed human studies that evaluated the effects of ondansetron and other 5HT3 receptor antagonists on sensory gating deficits or sensory processing. Of 11 eligible studies, eight included patients with schizophrenia who were chronically stable on antipsychotic medication; five measured sensory gating using the P50 suppression response to a repeated auditory stimulus; others included tests of visuoperceptual function. Three studies in healthy participants included tests of visuoperceptual and sensorimotor function. A consistent and robust finding (five studies) was that ondansetron and tropisetron (5HT3 antagonist and α7-nicotinic receptor partial agonist) improved sensory gating in patients with schizophrenia. Tropisetron also improved sustained visual attention in non-smoking patients. There was inconsistent evidence of the effects of 5HT3 antagonists on other measures of sensory processing, but interpretation was limited by the small number of studies, methodological heterogeneity and the potential confounding effects of concomitant medication in patients. Despite these limitations, we found strong evidence that selective 5HT3 antagonists (with or without direct α7-nicotinic partial agonist effects) improved sensory gating. Future studies should investigate how this relates to potential improvement in neurocognitive symptoms in antipsychotic naive patients with prodromal or milder symptoms, in order to understand the clinical implications.

Thermodynamic Optimization of Electrical and Thermal Energy Production of PV Panels and Potential for Valorization of the PV Low-Grade Thermal Energy into Cold

In the present study, the evaluation of potential improvement of the overall efficiency of a common PV panel, valorizing the heat extracted by a heat exchanger that is integrated on its back side, either into work using an endoreversible Carnot engine or into cold by using an endoreversible tri-thermal machine consisting of a heat-driven refrigeration machine operating between three temperature sources and sink (such as a liquid/gas absorption machine), was carried out. A simplified thermodynamic analysis of the PV/thermal collector shows that there are two optimal operating temperatures and of the panels, which maximize either the thermal exergy or the overall exergy of the PV panel, respectively. The cold produced by the endoreversible tri-thermal machine during the operating conditions of the PV/thermal collector at is higher with a coefficient of performance (COP) of 0.24 thanks to the higher heat recovery potential. In the case of using the cold produced by a tri-thermal machine to actively cool of an additional PV panel in order to increase its electrical performances, the operating conditions at the optimal temperature provide a larger and more stable gain: the gain is about 12.2% compared with the conventional PV panel when the operating temperature of the second cooled panel varies from 15 to 35 °C.

Examining the vintage effect in hedonic pricing using spatially varying coefficients models: a case study of single-family houses in the Canton of Zurich

This article examines the spatially varying effect of age on single-family house (SFH) prices. Age has been shown to be a key driver for house depreciation and is usually associated with a negative price effect. In practice, however, there exist deviations from this behavior which are referred to as vintage effects. We estimate a spatially varying coefficients (SVC) model to investigate the spatial structures of vintage effects on SFH pricing. For SFHs in the Canton of Zurich, Switzerland, we find substantial spatial variation in the age effect. In particular, we find a local, strong vintage effect primarily in urban areas compared to pure depreciative age effects in rural locations. Using cross validation, we assess the potential improvement in predictive performance by incorporating spatially varying vintage effects in hedonic models. We find a substantial improvement in out-of-sample predictive performance of SVC models over classical spatial hedonic models.

Sustainability Efficiency Assessment in the Turkish Manufacturing Sector

This chapter intends to measure environmental, social, and economic sustainability efficiency levels of the manufacturing companies listed in Borsa Istanbul Sustainability Index by using data envelopment analysis (DEA) based on the target year of 2019. In this context, considering the relationship between inputs and outputs determined as a result of the comprehensive review of the related literature, efficiency assessment is made by considering environmental, social, and economic indicators, which are the main dimensions of corporate sustainability. The input-oriented Charnes, Cooper, and Rhodes (CCR) and Banker, Charnes, and Cooper (BCC) models have been used in the efficiency measurement. According to the obtained efficiency scores for the relatively inefficient companies in terms of environmental, economic, and social dimensions, several suggestions are offered depending on the potential improvement rates for them.

Identification of Energy Efficiency Improvement Measures of an Existing Residential Building Using Audit-Assisted Energy Simulation and Analysis

Depleting energy sources are forcing humans to preserve energy and utilize it wisely. Globally, researchers are working to find ways to manage the energy crisis. Residential buildings are considered to be in the most energy demanding sector. Therefore, efforts are being made to reduce the increasing energy consumption and make the buildings energy efficient. The paper focuses on finding ways to retrofit the existing residential buildings into energy efficient buildings. This study evaluated the energy performance of a G+2 residential building with a total of 3 floors covering an area of 991.68 sq. meters, to identify relevant potential improvement measures. An energy analysis of the building was performed using information modeling assisted with energy audit data for accurate and realistic analysis. It was found that there is potential for the reduction of the annual energy usage and annual energy cost up to 2.33% and 4.54% respectively, by making improvements in the window to wall ratio. Another potential energy cost saving of 14.8% can be achieved by changing Heating, Ventilation, Air Conditioning (HVAC) type, and 7.62% of a reduction in cost can be achieved through modification in lighting fixtures. Moreover, installing solar photovoltaic panels can save up to PKR 1 million, and natural ventilation could result in saving more than PKR 0.2 million annually.

How Does an Audit or a Forensic Perspective Influence Auditors’ Fraud-Risk Assessment and Subsequent Risk Response?

This study examines whether priming auditors with a forensic perspective improves their fraud-risk assessments and subsequent audit-plan responses. We contribute to the literature by investigating a potential improvement in fraud detection that encourages auditors to take a forensic specialist’s perspective, while retaining the audit tenets of efficiently identifying and responding to risk. We prime auditors with a forensic perspective and compare their fraud performance to unprimed auditors in both low- and high-risk contexts, finding primed auditors assess fraud-risk significantly higher in all fraud-risk environments. In a high-risk environment, primed auditors propose a more appropriate audit-plan response. Relevant to fraud detection, these audit-plan modifications were consistent with those determined by a panel of audit and forensic experts. They exhibit a sensitivity in the low-risk environment, whereby their risk response is similar with that of the unprimed auditors. Finally, we find perspective-taking affects risk response through its influence on risk assessment.

Critical analysis of the role of the European Union on gender equality progress. The case of research policy

This article reviews how European policy in gender equality has generated an impact on the lives of European women since reporting and data has been compiled, analysing if there is a potential improvement that could be attributed to the existence of a supranational body and supranational policy. The article will identify some of the structures, regulations and gender policy in the European Union and its potential impact on member states. For that purpose, a wealth of knowledge, which has been developed in the last years by feminist and gender scholars, will be considered and reinterpreted highlighting the most relevant arguments, approaches and debates. Similarly, I will draw on the European Union data and analysis available on the numerous reports developed by multiple EU institutions. Given the limitations of this study and the extensive reach of gender policy within the Union, after a general overview, I will focus briefly on the research sphere, where a series of developments have shown an optimistic picture, despite the possible critics to the level of engagement and effective leadership of the Union in this area

Wooden Extra Stories in Concrete Block of Flats in Finland as an Ecologically Sensitive Engineering Solution

This chapter examined the various stages and benefits of wooden extra stories from the perspective of Finnish housing and real estate companies through interviews with professionals involved in these projects. Key findings highlighted are as follows: (1) in the feasibility study, project planning primarily focuses on property condition and potential improvement targets as well as other considerations, for example, compliance with current regulations and parking arrangements; (2) in the project planning, application of extra stories is thoroughly examined, and construction costs, profits, and the sale of building rights are discussed; (3) in implementation planning, issues related to building rights, city plan change, and conditions of the company that manages the property play an important role; and (4) during construction, frequent information updates are made to residents regarding the site arrangements and the construction program. Wooden extra floor construction, which requires commitment, investment, and cooperation among the interested parties, has great potential in construction technology, contracting mechanisms, and ecological engineering solutions. It is believed that this chapter will increase the dissemination of wooden extra stories, thus contributing to the greater use of more sustainable materials in renovation projects and the ecologically sensitive engineering approaches to meet the challenges arising from climate change.