Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases

We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.

Project scheduling and buffer management: A comprehensive review and future directions

In the project management, buffers are considered to handle uncertainties that lead to changes in project scheduling which in turn causes project delivery delay. The purpose of this survey is to discuss the state of the art on models and methods for project buffer management and time optimization of construction projects and manufacturing industries. There are not literally any surveys which review the literature of project buffer management and time optimization. This research adds to the previous literature surveys and focuses mainly on papers after 2014 but with a quick review on previous works. This research investigates the literature from project buffer sizing, project buffer consumption monitoring and project time/resource optimization perspectives.

Shut-in Stabilization Time Optimization for Better Reservoir Pressure Monitoring Harnessing Neural Network Modeling

Stabilization time is an essential key for pressure measurement accuracy. Obtaining representative pressure points in build-up tests for pressure-sensitive reservoirs is driven by optimizing stabilization time. An artificial intelligence technique was used in the study for testing pressure-sensitive reservoirs using measuring gauges. The stabilization time function of reservoir characteristics is generally calculated using the diffusivity equation where rock and fluid properties are honored. The artificial neural network (ANN) technique will be used to predict the stabilization time and optimize it using readily available and known inputs or parameters. The values obtained from the formula known as the diffusion formula and the ANN technique are then compared against the actual values measured from pressure gauges in the reservoirs. The optimization of the number of datasets required to be fed to the network to allow for coverage over the whole range is essential as opposed to the clustering of the datasets. A total of about 3000 pressure derivative samples from the wells were used in the testing, training, and validation of the ANN. The datasets are optimized by dividing them into three fractional parts, and the number optimized through monitoring the ANN performance. The optimization of the stabilization time is essential and leads to the improvement of the ANN learning process. The sensitivity analysis proves that the use of the formula and ANN technique, compared to actual datasets, is better since, in the formula and ANN technique, the time was optimized with an average absolute relative error of 3.67%. The results are near the same, especially when the ANN technique undergoes testing using known and easily available parameters. Time optimization is essential since discreet points or datasets in the ANN technique and formula would not work, allowing ANN to work in situations of optimization. The study was expected to provide additional data and information, considering that stabilization time is essential in obtaining the pressure map representation. ANN is a superior technique and, through its superiority, allows for proper optimization of time as a parameter. Thus it can predict reservoir log data almost accurately. The method used in the study shows the importance of optimizing pressure stabilization time through reduction. The study results can, therefore, be applied in reservoir testing to achieve optimal results.