NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia

2003 ◽  
Vol 201 (4) ◽  
pp. 609-615 ◽  
Author(s):  
Chunying Yu ◽  
Anh-Thy Le ◽  
Herman Yeger ◽  
Bernard Perbal ◽  
Benjamin A Alman
Keyword(s):  
Family Member ◽  
Growth Plate ◽  
Ccn Family

CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis

2018 ◽  
Vol 225 (3) ◽  
Author(s):  
Jin‐Feng Zhao ◽  
Hsiang‐Ying Chen ◽  
Jeng Wei ◽  
Shr‐Jeng Jim Leu ◽  
Tzong‐Shyuan Lee
Keyword(s):  
Family Member ◽  
Cholesterol Metabolism ◽  
Ccn Family

scholarly journals Normal growth and development in mice over-expressing the CCN family member WISP3

2009 ◽  
Vol 3 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Yukio Nakamura ◽  
Yajun Cui ◽  
Carol Fernando ◽  
Wendy E. Kutz ◽  
Matthew L. Warman
Keyword(s):  
Family Member ◽  
Growth And Development ◽  
Normal Growth ◽  
Ccn Family

scholarly journals KIF5B modulates central spindle organization in late-stage cytokinesis in chondrocytes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Huiyan Gan ◽  
Wenqian Xue ◽  
Ya Gao ◽  
Guixia Zhu ◽  
Danny Chan ◽  
...  
Keyword(s):  
Family Member ◽  
Growth Plate ◽  
Intracellular Transport ◽  
Primary Cilia ◽  
Microtubule Network ◽  
Central Spindle ◽  
Columnar Organization ◽  
Cell Rotation ◽  
Cilia Formation ◽  
Kinesin Family

Abstract Background The growth plate is a special region of the cartilage that drives longitudinal growth of long bones. Proliferating chondrocytes in the growth plate, arranged in columns, divide perpendicular to the long axis of the growth plate then intercalate to re-align with parental columns. Which molecular partners maintain growth plate columnar structures and chondrocyte cytokinesis has not been fully revealed. It is reported that kinesin family member 3A (KIF3A), a subunit of kinesin-2, plays an important role in maintaining columnar organization in growth plates via controlling primary cilia formation and cell proliferation. Result Here we identify kinesin family member 5B (KIF5B), the heavy chain of kinesin-1, a ubiquitously expressed motor protein for anterograde intracellular transport along the microtubule network, as a key modulator of cytokinesis in chondrocytes via maintenance of central spindle organization. We show that KIF5B is concentrated in the central spindle during cytokinesis in both primary chondrocytes and chondrogenic ATDC5 cells. Conclusion The failure of cytokinesis in KIF5B null chondrocytes leads to incomplete cell rotation, disrupting proliferation and differentiation, and results in a disorganized growth plate.

scholarly journals Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Yoshitaka Kase ◽  
Hideyuki Okano
Keyword(s):  
Family Member ◽  
Induced Pluripotent Stem Cell ◽  
Neural Cells ◽  
Ccn Family ◽  
Cns Disorders ◽  
Experimental Systems ◽  
Viral Virulence ◽  
Neural Stem Progenitor Cells ◽  
Induced Pluripotent ◽  
Human Ipsc

Abstract It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mechanism that triggers the COVID-19-associated CNS disorders, due to the lack of appropriate experimental systems. Our present study showed that angiotensin-converting enzyme-2 (ACE2), a cellular receptor for SARS-CoV-2, is expressed in human induced pluripotent stem cell (iPSC)-derived neural stem/progenitor cells (hiPSC-NS/PCs) and young neurons. Furthermore, together with database analysis, we found that a viral virulent factor CCN family member 1 (CCN1), which is known to be induced by SARS-CoV-2 infection, is expressed in these cells at basal levels. Considering the role of CCN1 which is known to be involved in viral toxicity and inflammation, hiPSC-NS/PCs could provide an excellent model for COVID-19-associated CNS disorders from the aspect of SARS-CoV-2 infection-ACE2-CCN1 axis. In addition, we identified compounds that reduce CCN1 expression. Collectively, our study using hiPSC-NS/PCs may aid in the development of a therapeutic target for COVID-19-related CNS disorders.

scholarly journals CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients

2021 ◽  
Author(s):  
Thabo Mahendiran ◽  
Roland Klingenberg ◽  
David Nanchen ◽  
Baris Gencer ◽  
David Meier ◽  
...  
Keyword(s):  
Infarct Size ◽  
Family Member ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Ccn Family ◽  
Early Marker
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