scholarly journals The Role of Platelets and ε-Aminocaproic Acid in Arthrogryposis, Renal Dysfunction, and Cholestasis (ARC) Syndrome Associated Hemorrhage

2015 ◽  
Vol 63 (3) ◽  
pp. 561-563 ◽  
Author(s):  
Angela C. Weyand ◽  
Rebecca M. Lombel ◽  
Steven W. Pipe ◽  
Jordan A. Shavit
Keyword(s):  
Renal Dysfunction ◽  
Aminocaproic Acid ◽  
Arc Syndrome

Postoperative Renal Dysfunction After On-Pump Versus Off-Pump Coronary Revascularization: Role of On-Pump Hemodilution and Transfusions

2006 ◽  
Vol 81 (4) ◽  
pp. 1548-1549 ◽  
Author(s):  
Robert H. Habib ◽  
Anoar Zacharias ◽  
Thomas A. Schwann ◽  
Christopher J. Riordan ◽  
Samuel J. Durham ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Coronary Revascularization ◽  
Off Pump

scholarly journals Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome

2004 ◽  
Vol 36 (4) ◽  
pp. 400-404 ◽  
Author(s):  
Paul Gissen ◽  
Colin A Johnson ◽  
Neil V Morgan ◽  
Janneke M Stapelbroek ◽  
Tim Forshew ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Renal Dysfunction ◽  
Arc Syndrome

scholarly journals Role of Renal Dysfunction as a Prognostic Factor in Acute Stroke Patients at a Tertiary Hospital in Northeastern Nigeria

2021 ◽  
Vol 32 (1) ◽  
pp. 199
Author(s):  
MohammadMaina Sulaiman ◽  
MusaMamman Watila ◽  
Jummai Shettima ◽  
Ibrahim Ummate ◽  
YakubuWilberforce Nyandaiti
Keyword(s):  
Prognostic Factor ◽  
Acute Stroke ◽  
Renal Dysfunction ◽  
Tertiary Hospital ◽  
Stroke Patients

scholarly journals Role of Protein C in Renal Dysfunction after Polymicrobial Sepsis

2007 ◽  
Vol 18 (3) ◽  
pp. 860-867 ◽  
Author(s):  
Akanksha Gupta ◽  
David T. Berg ◽  
Bruce Gerlitz ◽  
Ganesh R. Sharma ◽  
Samreen Syed ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Protein C ◽  
Polymicrobial Sepsis

scholarly journals Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

2015 ◽  
Vol 4 (10) ◽  
Author(s):  
Kohei Aoki ◽  
Yasushi Teshima ◽  
Hidekazu Kondo ◽  
Shotaro Saito ◽  
Akira Fukui ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Renal Dysfunction ◽  
Indoxyl Sulfate ◽  
Predisposing Factor

scholarly journals The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila

2011 ◽  
Vol 192 (3) ◽  
pp. 383-390 ◽  
Author(s):  
Mohammed Ali Akbar ◽  
Charles Tracy ◽  
Walter H.A. Kahr ◽  
Helmut Krämer
Keyword(s):  
Renal Dysfunction ◽  
Immune Defense ◽  
Specific Requirement ◽  
Phagosome Maturation ◽  
Late Endosomes ◽  
Arc Syndrome ◽  
Hops Complex

Arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome is a fatal recessive disorder caused by mutations in the VPS33B or VPS16B genes. Both encode homologues of the Vps33p and Vps16p subunits of the HOPS complex necessary for fusions of vacuoles in yeast. Here, we describe a mutation in the full-of-bacteria (fob) gene, which encodes Drosophila Vps16B. Flies null for fob are homozygous viable and fertile. They exhibit, however, a defect in their immune defense that renders them hypersensitive to infections with nonpathogenic bacteria. fob hemocytes (fly macrophages) engulf bacteria but fail to digest them. Phagosomes undergo early steps of maturation and transition to a Rab7-positive stage, but do not mature to fully acidified phagolysosomes. This reflects a specific requirement of fob in the fusion of phagosomes with late endosomes/lysosomes. In contrast, cargo of autophagosomes as well as endosomes exhibit normal lysosomal delivery in fob cells. These findings suggest that defects in phagosome maturation may contribute to symptoms of ARC patients including recurring infections.

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