scholarly journals Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules

2013 ◽  
Vol 1 (4) ◽  
Author(s):  
Muhammad U. Cheema ◽  
Ebbe T. Poulsen ◽  
Jan J. Enghild ◽  
Ewout Hoorn ◽  
Robert A. Fenton ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protein Aggregation ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Predominance of ACE2‐Dependent Metabolism of Angiotensin II But Not Angiotensin I In Sheep Renal Proximal Tubules and Urine

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Hossam A Shaltout ◽  
Brian Westwood ◽  
David Averill ◽  
Jorge Figueroa ◽  
Carlos Ferrario ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Proximal Tubules ◽  
Angiotensin I ◽  
Renal Proximal Tubules

scholarly journals Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

2021 ◽  
Author(s):  
Masayoshi Kukida ◽  
Lei Cai ◽  
Dien Ye ◽  
Hisashi Sawada ◽  
Yuriko Katsumata ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Antisense Oligonucleotides ◽  
Nonhuman Primates ◽  
Primary Source ◽  
Renin Angiotensin System ◽  
Proximal Tubules ◽  
Specific Inhibition ◽  
Angiotensin System ◽  
Renal Proximal Tubules ◽  
Cynomolgus Monkeys

AGT (Angiotensinogen) is the unique substrate of the renin-angiotensin system. Liver is the primary source of circulating AGT. The present study determined whether hepatocyte-derived AGT regulates renal AGT accumulation by injecting ASO (antisense oligonucleotides) targeting hepatocyte-derived AGT (GalNAc AGT ASO) into female cynomolgus monkeys. Hepatocyte-specific inhibition of AGT led to profound reductions of plasma AGT concentrations. AGT protein in S1 and S2 of renal proximal tubules was greatly diminished by GalNAc AGT ASO. Given the similarity between nonhuman primates and human, our findings support the notion that renal AGT is predominantly derived from liver, and liver regulates renal angiotensin II production in humans.

The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules

2010 ◽  
Vol 32 (7) ◽  
pp. 464-468 ◽  
Author(s):  
Linan Zhang ◽  
Fang Guo ◽  
Huicai Guo ◽  
Haiyan Wang ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

Crosstalk between the signaling pathways triggered by angiotensin II and adenosine in the renal proximal tubules: Implications for modulation of Na+-ATPase activity

Peptides ◽  
2008 ◽  
Vol 29 (11) ◽  
pp. 2033-2038 ◽  
Author(s):  
C.P. Gomes ◽  
L.R. Leão-Ferreira ◽  
A.A.S. Pinheiro ◽  
E. Gomes-Quintana ◽  
M. Wengert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Atpase Activity ◽  
Signaling Pathways ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Angiotensin II activates the ouabain-insensitive Na+-ATPase from renal proximal tubules through a G-protein

1999 ◽  
Vol 1416 (1-2) ◽  
pp. 309-319 ◽  
Author(s):  
L.B.A. Rangel ◽  
C. Caruso-Neves ◽  
L.S. Lara ◽  
F.L. Brasil ◽  
A.G. Lopes
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules

2008 ◽  
Vol 31 (12) ◽  
pp. 2155-2164 ◽  
Author(s):  
Yuehong LI ◽  
Hideomi YAMADA ◽  
Yoshihiro KITA ◽  
Masashi SUZUKI ◽  
Yoko ENDO ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Angiotensin Ii ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites
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