scholarly journals A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses

PROTEOMICS ◽  
2011 ◽  
Vol 11 (11) ◽  
pp. 2222-2235 ◽  
Author(s):  
Matthew P. Welberry Smith ◽  
Steven L. Wood ◽  
Alexandre Zougman ◽  
Jenny T. C. Ho ◽  
Jianhe Peng ◽  
...  
2011 ◽  
Vol 5 (9-10) ◽  
pp. 561-561 ◽  
Author(s):  
Matthew P. Welberry Smith ◽  
Steven L. Wood ◽  
Alexandre Zougman ◽  
Jenny T. C. Ho ◽  
Jianhe Peng ◽  
...  

Perception ◽  
2016 ◽  
Vol 46 (1) ◽  
pp. 31-49 ◽  
Author(s):  
Mick Zeljko ◽  
Philip M. Grove

The stream-bounce effect refers to a bistable motion stimulus that is interpreted as two targets either “streaming” past or “bouncing” off one another, and the manipulations that bias responses. Directional bias, according to Bertenthal et al., is an account of the effect proposing that low-level motion integration promotes streaming, and its disruption leads to bouncing, and it is sometimes cited either directly in a bottom-up fashion or indirectly under top-down control despite Sekuler and Sekuler finding evidence inconsistent with it. We tested two key aspects of the hypothesis: (a) comparable changes in speed should produce comparable disruptions and lead to similar effects; and (b) speed changes alone should disrupt integration without the need for additional more complex changes of motion. We found that target motion influences stream-bounce perception, but not as directional bias predicts. Our results support Sekuler and Sekuler and argue against the low-level motion signals driving perceptual outcomes in stream-bounce displays (directly or indirectly) and point to higher level inferential processes involving perceptual history and expectation. Directional bias as a mechanism should be abandoned and either another specific bottom-up process must be proposed and tested or consideration should be given to top-down factors alone driving the effect.


Author(s):  
Stijn Oosterlynck ◽  
Andreas Novy ◽  
Bernhard Leubolt ◽  
Carla Weinzierl

In this chapter, we undertake a systematic analysis of the empowerment dimension of social innovation initiatives. The notions of social innovation and empowerment have a rather similar history. We provide a brief historical overview of the concept of empowerment and the diverse and competing meanings the concept has acquired over time. We then specify three dimensions of empowerment to analyse the empowering potential of social innovation: the bottom-up and top-down dynamics of empowerment, the relation between individual and collective forms of empowerment and the extent to which empowerment has an instrumental or expressive focus. In the analysed case studies of social innovation initiatives, we observe a pre-eminence of top-down empowerment, the dominance of individual empowerment dynamics and a predominant focus on instrumental forms of empowerment in social innovation initiatives, especially in the governance of labour market activation.


2020 ◽  
Author(s):  
Golareh Khalilpour

Do liberal Western democracies share a common understanding of democracy? If so, why is there a transatlantic divide over the promotion of democracy? While the US applies a bottom-up strategy in this respect, the European Union pursues a top-down approach. While there is consensus as to the desirability of the external promotion of democracy, disagreement persists as to what kinds of strategies work more effectively. This book suggests that differences between the US and Europe in terms of the promotion of democracy derive from different historical backgrounds, experiences with political modernisation and, hence, historically embedded conceptions of democracy. Democracy promoters choose instruments that advance their vision of an ideal transition and that are congruent with their respective understandings of democracy. This book’s analysis of media debates in four Western democracies reveals different understandings with regard to the key aspects of democracy across the Atlantic and contributes to research on the transatlantic divide in this regard.


PsycCRITIQUES ◽  
2005 ◽  
Vol 50 (19) ◽  
Author(s):  
Michael Cole
Keyword(s):  
Top Down ◽  

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