Comparison of the anticancer effects between helium plasma jets and electrochemical treatment (EChT)

Nonthermal plasma is a promising novel therapy for the alteration of biological and clinical functions of cells and tissues, including apoptosis and inhibition of tumor progression. This therapy generates reactive oxygen and nitrogen species (RONS), which play a major role in anticancer effects. Previous research has verified that plasma jets can selectively induce apoptosis in various cancer cells, suggesting that it could be a potentially effective novel therapy in combination with or as an alternative to conventional therapeutic methods. In this study, we determined the effects of nonthermal air soft plasma jets on a U87 MG brain cancer cell line, including the dose- and time-dependent effects and the physicochemical and biological correlation between the RONS cascade and p38/mitogen-activated protein kinase (MAPK) signaling pathway, which contribute to apoptosis. The results indicated that soft plasma jets efficiently inhibit cell proliferation and induce apoptosis in U87 MG cells but have minimal effects on astrocytes. These findings revealed that soft plasma jets produce a potent cytotoxic effect via the initiation of cell cycle arrest and apoptosis. The production of reactive oxygen species (ROS) in cells was tested, and an intracellular ROS scavenger, N-acetyl cysteine (NAC), was examined. Our results suggested that soft plasma jets could potentially be used as an effective approach for anticancer therapy.

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Effects of nitrogen impurity on the atmospheric pressure helium plasma jets exposed to a nitrogen environment

Physics of Plasmas ◽

10.1063/5.0020468 ◽

2020 ◽

Vol 27 (10) ◽

pp. 103511

Author(s):

YuanYuan Jiang ◽

Yanhui Wang ◽

Shiyuan Cong ◽

Jiao Zhang ◽

Dezhen Wang

Keyword(s):

Atmospheric Pressure ◽

Plasma Jets ◽

Helium Plasma ◽

Nitrogen Impurity

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Two-dimensional numerical study of two counter-propagating helium plasma jets in air at atmospheric pressure

Physics of Plasmas ◽

10.1063/1.4882440 ◽

2014 ◽

Vol 21 (6) ◽

pp. 063505 ◽

Cited By ~ 11

Author(s):

Wen Yan ◽

Fucheng Liu ◽

Chaofeng Sang ◽

Dezhen Wang

Keyword(s):

Atmospheric Pressure ◽

Numerical Study ◽

Plasma Jets ◽

Helium Plasma ◽

Two Dimensional

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Comparison between the water activation effects by pulsed and sinusoidal helium plasma jets

Physics of Plasmas ◽

10.1063/1.5016510 ◽

2018 ◽

Vol 25 (1) ◽

pp. 013520 ◽

Cited By ~ 6

Author(s):

Han Xu ◽

Dingxin Liu ◽

Wenjie Xia ◽

Chen Chen ◽

Weitao Wang ◽

...

Keyword(s):

Plasma Jets ◽

Helium Plasma ◽

Water Activation

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A spectroscopic study of the effect of humidity on the atmospheric pressure helium plasma jets

Current Applied Physics ◽

10.1016/j.cap.2018.06.012 ◽

2018 ◽

Vol 18 (11) ◽

pp. 1375-1380

Author(s):

Duksun Han

Keyword(s):

Spectroscopic Study ◽

Atmospheric Pressure ◽

Plasma Jets ◽

Helium Plasma

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Tailoring the Chemistry of Plasma-Activated Water Using a DC-Pulse-Driven Non-Thermal Atmospheric-Pressure Helium Plasma Jet

Plasma ◽

10.3390/plasma2020010 ◽

2019 ◽

Vol 2 (2) ◽

pp. 127-137 ◽

Cited By ~ 1

Author(s):

Oh ◽

Szili ◽

Hatta ◽

Ito ◽

Shirafuji

Keyword(s):

Hydrogen Peroxide ◽

Atmospheric Pressure ◽

Pulse Width ◽

Plasma Jet ◽

Plasma Jets ◽

Helium Plasma ◽

Uv Absorption Spectroscopy ◽

Pulse Polarity ◽

Plasma Activated Water

We investigate the use of a DC-pulse-driven non-thermal atmospheric-pressure He plasma jet in the regulation of hydrogen peroxide (H2O2), nitrite (NO2−), nitrate (NO3−), and oxygen (O2) in deionized (DI) water. The production of these molecules is measured by in situ UV absorption spectroscopy of the plasma-activated water (PAW). Variations in the pulse polarity and pulse width have a significant influence on the resultant PAW chemistry. However, the trends in the concentrations of H2O2, NO2−, NO3−, and O2 are variable, pointing to the possibility that changes in the pulse polarity and pulse width might influence other plasma variables that also impact on the PAW chemistry. Overall, the results presented in this study highlight the possibility of using DC-pulse-driven plasma jets to tailor the chemistry of PAW, which opens new opportunities for the future development of optimal PAW formulations across diverse applications ranging from agriculture to medicine.

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