Nitrosulindac (NCX 1102): A new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines

The Prostate ◽  
2004 ◽  
Vol 61 (2) ◽  
pp. 132-141 ◽  
Author(s):  
Sandra Huguenin ◽  
Jocelyne Fleury-Feith ◽  
Laurence Kheuang ◽  
Marie-Claude Jaurand ◽  
Manlio Bolla ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Epithelial Cell ◽  
Cell Lines ◽  
Inflammatory Drug ◽  
Epithelial Cell Lines ◽  
Anti Inflammatory ◽  
Prostatic Epithelial Cell

scholarly journals Tumor-associated myeloid cells promote tumorigenesis of non-tumorigenic human and murine prostatic epithelial cell lines

2018 ◽  
Vol 67 (6) ◽  
pp. 873-883 ◽  
Author(s):  
Stephanie N. Sass ◽  
Kimberley D. Ramsey ◽  
Shawn M. Egan ◽  
Jianmin Wang ◽  
Eduardo Cortes Gomez ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Myeloid Cells ◽  
Epithelial Cell Lines ◽  
Prostatic Epithelial Cell

scholarly journals Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines

2017 ◽  
Vol 119 ◽  
pp. 1-10 ◽  
Author(s):  
Lucas A. Rigo ◽  
Cristiane S. Carvalho-Wodarz ◽  
Adriana R. Pohlmann ◽  
Silvia S. Guterres ◽  
Nicole Schneider-Daum ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Barrier Function ◽  
Epithelial Cell Lines ◽  
Pulmonary Epithelial Cell ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Chromosomal instability of SV40-transformed human prostatic epithelial cell lines

1982 ◽  
Vol 33 (1-2) ◽  
pp. 170-178 ◽  
Author(s):  
Y. Ohnuki ◽  
J.F. Lechner ◽  
S.E. Bates ◽  
L.W. Jones ◽  
M.E. Kaighn
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Chromosomal Instability ◽  
Epithelial Cell Lines ◽  
Prostatic Epithelial Cell

scholarly journals Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines

2005 ◽  
Vol 26 (7) ◽  
pp. 1196-1206 ◽  
Author(s):  
Lori D. Dwyer-Nield ◽  
Mary C. Srebernak ◽  
Bradley S. Barrett ◽  
Jinhee Ahn ◽  
Pippa Cosper ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Epithelial Cell ◽  
Cell Lines ◽  
Lung Epithelial Cell ◽  
Mouse Lung ◽  
Lung Epithelial ◽  
Epithelial Cell Lines

Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines

1998 ◽  
Vol 274 (6) ◽  
pp. L922-L932 ◽  
Author(s):  
David C. Thompson ◽  
Stephanie E. Porter ◽  
Alison K. Bauer ◽  
Kumuda C. Das ◽  
Brandon Ou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Cell Lines ◽  
No Synthase ◽  
Lung Epithelial Cells ◽  
No Production ◽  
Murine Lung ◽  
Lung Epithelial ◽  
Epithelial Cell Lines

Cytomix, a mixture of interferon-γ, tumor necrosis factor-α, and interleukin-1β, induces nitric oxide (NO) production in lung epithelial cell lines. It is not known whether neoplastic transformation alters a cell’s ability to form NO in response to cytokines. The present study investigated NO formation in two murine lines of immortalized “normal” (nontumorigenic) lung epithelial cells of alveolar type II origin, E10 and C10, and their sibling spontaneous transformants, E9 and A5. Nontumorigenic cells elaborated much more NO after cytomix exposure than did their tumorigenic counterparts. NO production was prevented by inhibiting protein synthesis and NO synthase and attenuated by dexamethasone. Northern and Western blot analyses of inducible NO synthase (iNOS) demonstrated cytomix-induced induction of iNOS only in nontumorigenic cells. The deficiency in NO production in tumorigenic cells was not associated with reduced iNOS mRNA stability or with differences in cytomix-induced nuclear factor-κB activation. Although cytomix caused a greater production of NO in E10 cells than in E9 cells, the same treatment induced equivalent proliferation in both cell lines. These results indicate a specific deficiency in cytokine-induced NO synthesis in transformed murine lung epithelial cells relative to their normal progenitor cells and provide a model for investigating iNOS regulation.

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