Modulating Bcl-2 Family Proteins and Caspase-3 in Induction of Apoptosis by Paeoniflorin in Human Cervical Cancer Cells

2011 ◽  
Vol 25 (10) ◽  
pp. 1551-1557 ◽  
Author(s):  
Lili Zhang ◽  
Shulan Zhang
2007 ◽  
Vol 25 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Liangfang Shen ◽  
Shan Zeng ◽  
Jia Chen ◽  
Meizuo Zhong ◽  
Huixiang Yang ◽  
...  

2012 ◽  
Vol 28 (6) ◽  
pp. 2264-2270 ◽  
Author(s):  
JIA-YING XU ◽  
QING-HUI MENG ◽  
YU CHONG ◽  
YANG JIAO ◽  
LIN ZHAO ◽  
...  

2006 ◽  
Vol 34 (03) ◽  
pp. 401-408 ◽  
Author(s):  
Jong-Seok Yoon ◽  
Jung-Chul Seo ◽  
Sang-Won Han

Pinelliae Rhizoma has been used traditionally in Korea to promote the liver Qi activity and the function of the digestive system. We investigated whether the Pinelliae Rhizoma herbal-acupuncture solution (PRHS) would induce cell-death on SNU-17, human cervical cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to investigate the cytotoxicity of PRHS. The cell death was identified as apoptosis with 4, 6-diamidineo-2-phenylindole (DAPI) staining, and terminal deoxy-nucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. PRHS could induce apoptosis of SNU-17 via Bax-related caspase-3 activation. The expressions of both Bax, a pro-apoptotic gene, and caspase-3, an apoptotic gene, were increased. The results might provide the experimental data for the clinical use of Pinelliae Rhizoma on cervical cancer.


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