A Potential In Vitro and In Vivo anti-HIV Drug Screening System for Chinese Herbal Medicines

2011 ◽  
Vol 26 (6) ◽  
pp. 899-907 ◽  
Author(s):  
Long Feng ◽  
Li Wang ◽  
Yun-yun Ma ◽  
Min Li ◽  
Guo-Qiang Zhao
Keyword(s):  
Drug Screening ◽  
Herbal Medicines ◽  
Screening System ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Anti Hiv

Herb-Drug Interaction of 50 Chinese Herbal Medicines on CYP3A4 Activity in Vitro and in Vivo

2012 ◽  
Vol 40 (01) ◽  
pp. 57-73 ◽  
Author(s):  
Li-Heng Pao ◽  
Oliver Yoa-Pu Hu ◽  
Hsien-Yuan Fan ◽  
Chang-Ching Lin ◽  
Liang-Chun Liu ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Drug Interactions ◽  
Human Liver ◽  
Liver Microsomes ◽  
Herbal Medicines ◽  
Human Liver Microsomes ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The purpose of this study is to evaluate the effects of Chinese herbal medicines on the enzymatic activity of CYP3A4 and the possible metabolism-based herb-drug interactions in human liver microsomes and in rats. Fifty single-herbal preparations were screened for the activity of CYP3A4 using human liver microsomes for an in vitro probe reaction study. The enzymatic activity of CYP3A4 was estimated by determing the 6β-hydroxytestosterone metabolized from testosterone performed on a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Huang Qin (Scutellaria baicalensis Geprgi), Mu Dan Pi (Paeonia suffruticosa Andr.), Ji Shiee Terng (Spatholobus suberectus Dunn.) and Huang Qi (Astragalus membranaceus [Fisch] Bge) have been demonstrated to have remarkable inhibiting effects on the metabolism of CYP3A4, whereas Xi Yi Hua (Magnolia biondii Pamp.) exhibited a moderate inhibition. These five single herbs were further investigated in an animal study using midazolam. Mu Dan Pi, Ji Shiee Terng and Huang Qi were observed to have greatly increased in the C max and AUC of midazolam. This study provides evidence of possible herb-drug interactions involved with certain single herbs.

Effects of the Chinese Herbal Medicines Bupleuri radix, Ginseng radix, and Zingiberis rhizoma on Lymphatic Vessel Activity in Rats

2006 ◽  
Vol 34 (06) ◽  
pp. 1063-1068 ◽  
Author(s):  
Michiaki Yamakage ◽  
Jun-Ichi Hattori ◽  
Jun-Ichi Satoh ◽  
Akiyoshi Namiki
Keyword(s):  
Herbal Medicine ◽  
Lymphatic Vessel ◽  
Herbal Medicines ◽  
In Vitro Study ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Radix Ginseng ◽  
Bupleuri Radix

The aim of the present study was to determine the effects of the Chinese herbal medicines Bupleuri radix, Ginseng radix and Zingiberis rhizoma on spontaneous lymphatic vessel activity. The effect of each herbal medicine on in vivo lymphatic flow was examined by injection of dye into the femoral regions of rats after feeding with the herbal medicines. In an in vitro study, spontaneous changes in diameter of the rat thoracic duct were monitored, and each segment was exposed to each herbal medicine. In the in vivo study, 100% of the right iliac lymphatic node were positively stained in the herbal medicine group, whereas only 40% of the node were positively stained in the control group. In the in vitro study, Bupleuri radix and Ginseng radix increased the amplitude of spontaneous activity of lymphatic vessels in a concentration-dependent manner with or without L-NAME, an NO synthase inhibitor. The results indicated that the herbal medicines Bupleuri radix and Ginseng radix activated spontaneous lymphatic vasomotion and lymph flow, and the mechanisms of this effect seem to be independent of endothelial cells.

In vitro anti-microbial and in vivo cytokine modulating effects of different prepared Chinese herbal medicines

2006 ◽  
Vol 44 (12) ◽  
pp. 2078-2085 ◽  
Author(s):  
Shyh-Jye Lin ◽  
Chung-Shih Chen ◽  
Shih-Shen Lin ◽  
Ming-Yung Chou ◽  
Hung-Che Shih ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Emerging Role of Chinese Herbal Medicines in the Treatment of Pancreatic Fibrosis

2019 ◽  
Vol 47 (04) ◽  
pp. 709-726 ◽  
Author(s):  
Chang Liu ◽  
Shuang Li ◽  
Qingkai Zhang ◽  
Fangyue Guo ◽  
Mengying Tong ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Pancreatic Fibrosis ◽  
Research Progress ◽  
Common Disease ◽  
Innovative Drug ◽  
Chinese Herbal ◽  
Pathologic Characteristic ◽  
Prevention And Cure

Pancreatic fibrosis is the main pathologic characteristic in chronic pancreatitis (CP), a common disease that arises from surgery. Pancreatitis is caused by various etiologies, but the mechanism of fibrosis is not completely understood. Existing clinical approaches mainly focus on mitigating the symptoms and therefore do not cure the phenomena. In recent years, there has been a heightened interest in the use of Chinese herbal medicine (CHMs) in the prevention and cure of CP as expressed by increasing numbers of clinical and experimental research. Despite early cell culture and animal models, CHMs are able to interact with plenty of molecular targets involved in the pathogenesis of pancreatic fibrosis mostly via the TGF-[Formula: see text]/Smads pathway; however, integrated and up-to-date communication in this domain is unavailable. This review focuses on the research progress of CHMs against pancreatic fibrosis due to CP in vitro and in vivo and summarizes the potential mechanisms. We also outlined the toxicology of some CHMs for fibrosis treatment in order to provide a fuller understanding of drug safety. This review may provide reference for further innovative drug research and the future development of treatments for CP with pancreatic fibrosis.

scholarly journals Effect of Chinese herbal medicines on rumen fermentation, methanogenesis and microbial flora in vitro

2019 ◽  
Vol 49 (1) ◽  
pp. 63 ◽  
Author(s):  
W.J. Wang ◽  
S.P. Wang ◽  
D.M. Luo ◽  
X.L. Zhao ◽  
M.J. Yin ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Rumen Fermentation ◽  
Microbial Flora ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines

2019 ◽  
Vol 89 ◽  
pp. 45-53 ◽  
Author(s):  
Lu Li ◽  
Ling Yin Tang ◽  
Bo Liang ◽  
Rongyun Wang ◽  
Qiuhua Sun ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

scholarly journals The Potential of Chinese Herbal Medicines in the Treatment of Cervical Cancer

2019 ◽  
Vol 18 ◽  
pp. 153473541986169 ◽  
Author(s):  
Yi-Hsuan Hsiao ◽  
Chiao-Wen Lin ◽  
Po-Hui Wang ◽  
Min-Chien Hsin ◽  
Shun-Fa Yang
Keyword(s):  
Cervical Cancer ◽  
Treatment Options ◽  
Herbal Medicines ◽  
Antitumor Effects ◽  
Clinical Safety ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Global Health Issue ◽  
Underlying Mechanisms

Cervical cancer is a global health issue and places a considerable economic and medical burden on society. Thus, a concerted effort to improve the treatment of cervical cancer is warranted. Although several treatment options are currently available for treating patients with cervical cancer, such as chemoradiation and neoadjuvant or adjuvant chemotherapy, more aggressive systemic therapies and newer therapeutic agents are under investigation. Medicinal herbs have long been used to treat diseases. In this review, we summarize studies analyzing the antitumor effects and underlying mechanisms of Chinese herbal medicines, including the effects of crude extracts and compounds in vitro or in animal models for inducing apoptosis and inhibiting invasion or metastasis. Chinese herbal medicines with therapeutic targeting, such as those that interfere with tumor growth and progression in cervical cancer, have been widely investigated. To apply Chinese herbal medicine in the treatment of cervical cancer, adequate clinical studies are required to confirm its clinical safety and efficiency. Further investigations focused on the purification, pharmacokinetics, and identification of compounds from Chinese herbal medicines in cervical cancer treatment are necessary to achieve the aforementioned treatment goals.

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