scholarly journals An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity

Author(s):  
Bojiang Shen ◽  
John Truong ◽  
Ray Helliwell ◽  
Suresh Govindaraghavan ◽  
Nikolaus J Sucher
2006 ◽  
Vol 34 (06) ◽  
pp. 1063-1068 ◽  
Author(s):  
Michiaki Yamakage ◽  
Jun-Ichi Hattori ◽  
Jun-Ichi Satoh ◽  
Akiyoshi Namiki

The aim of the present study was to determine the effects of the Chinese herbal medicines Bupleuri radix, Ginseng radix and Zingiberis rhizoma on spontaneous lymphatic vessel activity. The effect of each herbal medicine on in vivo lymphatic flow was examined by injection of dye into the femoral regions of rats after feeding with the herbal medicines. In an in vitro study, spontaneous changes in diameter of the rat thoracic duct were monitored, and each segment was exposed to each herbal medicine. In the in vivo study, 100% of the right iliac lymphatic node were positively stained in the herbal medicine group, whereas only 40% of the node were positively stained in the control group. In the in vitro study, Bupleuri radix and Ginseng radix increased the amplitude of spontaneous activity of lymphatic vessels in a concentration-dependent manner with or without L-NAME, an NO synthase inhibitor. The results indicated that the herbal medicines Bupleuri radix and Ginseng radix activated spontaneous lymphatic vasomotion and lymph flow, and the mechanisms of this effect seem to be independent of endothelial cells.


Author(s):  
Chunhong Li ◽  
Yulong Dong ◽  
Zhong Hao Li ◽  
Ruihua Zhang ◽  
Ruiling Qin ◽  
...  

A study was conducted to evaluate the effect of traditional Chinese herbal medicines (TCHM) on egg production, egg quality and antioxidant enzyme activities in chickens, astragalus membranaceus (AM), angelicae sinensis extract (ASE) and danggui buxue san (DBS) were used for the study. 300 hens of 56 weeks of age were randomized into 10 groups. AM, ASE and DBS were added into the diets of the animals at the dosage of 5mg/Kg,10 mg/Kg and 15 mg/Kg respectively from group Ito group IX. The hens of group X, as of control, were fed with the diet without TCHM. The added TCHM Period was 15 days. The results showed that DBS had the ability on improving egg production, egg quality and antioxidant enzyme activities in chickens. At the same time, DBS was added into the diets of the animals at the dosage of 10mg/Kg was recommended for application.


2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.


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