scholarly journals The Potential of Chinese Herbal Medicines in the Treatment of Cervical Cancer

2019 ◽  
Vol 18 ◽  
pp. 153473541986169 ◽  
Author(s):  
Yi-Hsuan Hsiao ◽  
Chiao-Wen Lin ◽  
Po-Hui Wang ◽  
Min-Chien Hsin ◽  
Shun-Fa Yang
Keyword(s):  
Cervical Cancer ◽  
Treatment Options ◽  
Herbal Medicines ◽  
Antitumor Effects ◽  
Clinical Safety ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Global Health Issue ◽  
Underlying Mechanisms

Cervical cancer is a global health issue and places a considerable economic and medical burden on society. Thus, a concerted effort to improve the treatment of cervical cancer is warranted. Although several treatment options are currently available for treating patients with cervical cancer, such as chemoradiation and neoadjuvant or adjuvant chemotherapy, more aggressive systemic therapies and newer therapeutic agents are under investigation. Medicinal herbs have long been used to treat diseases. In this review, we summarize studies analyzing the antitumor effects and underlying mechanisms of Chinese herbal medicines, including the effects of crude extracts and compounds in vitro or in animal models for inducing apoptosis and inhibiting invasion or metastasis. Chinese herbal medicines with therapeutic targeting, such as those that interfere with tumor growth and progression in cervical cancer, have been widely investigated. To apply Chinese herbal medicine in the treatment of cervical cancer, adequate clinical studies are required to confirm its clinical safety and efficiency. Further investigations focused on the purification, pharmacokinetics, and identification of compounds from Chinese herbal medicines in cervical cancer treatment are necessary to achieve the aforementioned treatment goals.

scholarly journals Molecular and Cellular Mechanisms of Metformin in Cervical Cancer

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2545
Author(s):  
Ya-Hui Chen ◽  
Po-Hui Wang ◽  
Pei-Ni Chen ◽  
Shun-Fa Yang ◽  
Yi-Hsuan Hsiao
Keyword(s):  
Cervical Cancer ◽  
Potential Role ◽  
Treatment Options ◽  
Cellular Mechanisms ◽  
Anticancer Effects ◽  
Clinical Benefits ◽  
Underlying Mechanisms

Cervical cancer is one of the major gynecologic malignancies worldwide. Treatment options include chemotherapy, surgical resection, radiotherapy, or a combination of these treatments; however, relapse and recurrence may occur, and the outcome may not be favorable. Metformin is an established, safe, well-tolerated drug used in the treatment of type 2 diabetes; it can be safely combined with other antidiabetic agents. Diabetes, possibly associated with an increased site-specific cancer risk, may relate to the progression or initiation of specific types of cancer. The potential effects of metformin in terms of cancer prevention and therapy have been widely studied, and a number of studies have indicated its potential role in cancer treatment. The most frequently proposed mechanism underlying the diabetes–cancer association is insulin resistance, which leads to secondary hyperinsulinemia; furthermore, insulin may exert mitogenic effects through the insulin-like growth factor 1 (IGF-1) receptor, and hyperglycemia may worsen carcinogenesis through the induction of oxidative stress. Evidence has suggested clinical benefits of metformin in the treatment of gynecologic cancers. Combining current anticancer drugs with metformin may increase their efficacy and diminish adverse drug reactions. Accumulating evidence is indicating that metformin exerts anticancer effects alone or in combination with other agents in cervical cancer in vitro and in vivo. Metformin might thus serve as an adjunct therapeutic agent for cervical cancer. Here, we reviewed the potential anticancer effects of metformin against cervical cancer and discussed possible underlying mechanisms.

scholarly journals Effect of Chinese herbal medicines on rumen fermentation, methanogenesis and microbial flora in vitro

2019 ◽  
Vol 49 (1) ◽  
pp. 63 ◽  
Author(s):  
W.J. Wang ◽  
S.P. Wang ◽  
D.M. Luo ◽  
X.L. Zhao ◽  
M.J. Yin ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Rumen Fermentation ◽  
Microbial Flora ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

A Potential In Vitro and In Vivo anti-HIV Drug Screening System for Chinese Herbal Medicines

2011 ◽  
Vol 26 (6) ◽  
pp. 899-907 ◽  
Author(s):  
Long Feng ◽  
Li Wang ◽  
Yun-yun Ma ◽  
Min Li ◽  
Guo-Qiang Zhao
Keyword(s):  
Drug Screening ◽  
Herbal Medicines ◽  
Screening System ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Anti Hiv

Herb-Drug Interaction of 50 Chinese Herbal Medicines on CYP3A4 Activity in Vitro and in Vivo

2012 ◽  
Vol 40 (01) ◽  
pp. 57-73 ◽  
Author(s):  
Li-Heng Pao ◽  
Oliver Yoa-Pu Hu ◽  
Hsien-Yuan Fan ◽  
Chang-Ching Lin ◽  
Liang-Chun Liu ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Drug Interactions ◽  
Human Liver ◽  
Liver Microsomes ◽  
Herbal Medicines ◽  
Human Liver Microsomes ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The purpose of this study is to evaluate the effects of Chinese herbal medicines on the enzymatic activity of CYP3A4 and the possible metabolism-based herb-drug interactions in human liver microsomes and in rats. Fifty single-herbal preparations were screened for the activity of CYP3A4 using human liver microsomes for an in vitro probe reaction study. The enzymatic activity of CYP3A4 was estimated by determing the 6β-hydroxytestosterone metabolized from testosterone performed on a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Huang Qin (Scutellaria baicalensis Geprgi), Mu Dan Pi (Paeonia suffruticosa Andr.), Ji Shiee Terng (Spatholobus suberectus Dunn.) and Huang Qi (Astragalus membranaceus [Fisch] Bge) have been demonstrated to have remarkable inhibiting effects on the metabolism of CYP3A4, whereas Xi Yi Hua (Magnolia biondii Pamp.) exhibited a moderate inhibition. These five single herbs were further investigated in an animal study using midazolam. Mu Dan Pi, Ji Shiee Terng and Huang Qi were observed to have greatly increased in the C max and AUC of midazolam. This study provides evidence of possible herb-drug interactions involved with certain single herbs.

Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines

2019 ◽  
Vol 89 ◽  
pp. 45-53 ◽  
Author(s):  
Lu Li ◽  
Ling Yin Tang ◽  
Bo Liang ◽  
Rongyun Wang ◽  
Qiuhua Sun ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases

2005 ◽  
Vol 98 (3) ◽  
pp. 329-333 ◽  
Author(s):  
Yang Li ◽  
Chen Xu ◽  
Qiang Zhang ◽  
Jun Yan Liu ◽  
Ren Xiang Tan
Keyword(s):  
Helicobacter Pylori ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Effects of the Chinese Herbal Medicines Bupleuri radix, Ginseng radix, and Zingiberis rhizoma on Lymphatic Vessel Activity in Rats

2006 ◽  
Vol 34 (06) ◽  
pp. 1063-1068 ◽  
Author(s):  
Michiaki Yamakage ◽  
Jun-Ichi Hattori ◽  
Jun-Ichi Satoh ◽  
Akiyoshi Namiki
Keyword(s):  
Herbal Medicine ◽  
Lymphatic Vessel ◽  
Herbal Medicines ◽  
In Vitro Study ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Radix Ginseng ◽  
Bupleuri Radix

The aim of the present study was to determine the effects of the Chinese herbal medicines Bupleuri radix, Ginseng radix and Zingiberis rhizoma on spontaneous lymphatic vessel activity. The effect of each herbal medicine on in vivo lymphatic flow was examined by injection of dye into the femoral regions of rats after feeding with the herbal medicines. In an in vitro study, spontaneous changes in diameter of the rat thoracic duct were monitored, and each segment was exposed to each herbal medicine. In the in vivo study, 100% of the right iliac lymphatic node were positively stained in the herbal medicine group, whereas only 40% of the node were positively stained in the control group. In the in vitro study, Bupleuri radix and Ginseng radix increased the amplitude of spontaneous activity of lymphatic vessels in a concentration-dependent manner with or without L-NAME, an NO synthase inhibitor. The results indicated that the herbal medicines Bupleuri radix and Ginseng radix activated spontaneous lymphatic vasomotion and lymph flow, and the mechanisms of this effect seem to be independent of endothelial cells.

scholarly journals The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Liqian Chen ◽  
Zhengmao Luo ◽  
Ming Wang ◽  
Jingru Cheng ◽  
Fei Li ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Mechanisms Of Action ◽  
Lower Serum ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Underlying Mechanisms

Background. Chinese herbal medicines are widely used to lower serum uric acid levels. However, no systemic review summarizes and evaluates their efficacies and the underlying mechanisms of action. Objectives. To evaluate the clinical and experimental evidences for the effectiveness and the potential mechanism of Chinese herbal medicines in lowering serum uric acid levels. Methods. Four electronic databases PubMed, Wed of Science, the Cochrane Library and Embase were used to search for Chinese herbal medicines for their effects in lowering serum uric acid levels, dated from 1 January 2009 to 19 August 2020. For clinical trials, randomized controlled trials (RCTs) were included; and for experimental studies, original articles were included. The methodological quality of RCTs was assessed according to the Cochrane criteria. For clinical trials, a meta-analysis of continuous variables was used to obtain pooled effects. For experimental studies, lists were used to summarize and integrate the mechanisms involved. Results. A total of 10 clinical trials and 184 experimental studies were included. Current data showed that Chinese herbal medicines have promising clinical efficacies in patients with elevated serum uric acid levels (SMD: −1.65, 95% CI: −3.09 to −0.22; p = 0.024). There was no significant difference in serum uric acid levels between Chinese herbal medicine treatments and Western medicine treatments (SMD: −0.13, 95% CI: −0.99 to 0.74; p = 0.772). Experimental studies revealed that the mechanistic signaling pathways involved in the serum uric acid lowering effects include uric acid synthesis, uric acid transport, inflammation, renal fibrosis and oxidative stress. Conclusions. The clinical studies indicate that Chinese herbal medicines lower serum uric acid levels. Further studies with sophisticated research design can further demonstrate the efficacy and safety of these Chinese herbal medicines in lowering serum uric acid levels and reveal a comprehensive picture of the underlying mechanisms of action.

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