Therapeutic Effect of Rhizoma Dioscoreae Nipponicae on Gouty Arthritis Based on the SDF-1/CXCR 4 and p38 MAPK Pathway: An In Vivo and In Vitro Study

2013 ◽  
Vol 28 (2) ◽  
pp. 280-288 ◽  
Author(s):  
Fang Lu ◽  
Lei Liu ◽  
Dong-hua Yu ◽  
Xu-zhao Li ◽  
Qi Zhou ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Therapeutic Effect ◽  
Mapk Pathway ◽  
Gouty Arthritis ◽  
In Vitro Study ◽  
Vitro Study ◽  
P38 Mapk Pathway

Tougu Xiaotong capsules may inhibit p38 MAPK pathway-mediated inflammation: In vivo and in vitro verification

2020 ◽  
Vol 249 ◽  
pp. 112390 ◽  
Author(s):  
Xihai Li ◽  
Zhenli Zhang ◽  
Wenna Liang ◽  
Jianwei Zeng ◽  
Xiang Shao ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals Therapeutic effect of total saponins from Dioscorea nipponica makino on gouty arthritis based on the NF-κB signal pathway: An In vitro study

2016 ◽  
Vol 12 (47) ◽  
pp. 235 ◽  
Author(s):  
Shumin Liu ◽  
Qi Zhou ◽  
Donghua Yua ◽  
Ning Zhang
Keyword(s):  
Therapeutic Effect ◽  
Gouty Arthritis ◽  
In Vitro Study ◽  
Signal Pathway ◽  
Vitro Study ◽  
Dioscorea Nipponica Makino

Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway

2007 ◽  
Vol 86 (6) ◽  
pp. 331-344 ◽  
Author(s):  
Haitao Wu ◽  
Xuan Wang ◽  
Shuhong Liu ◽  
Yan Wu ◽  
Tong Zhao ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
Myogenic Differentiation ◽  
P38 Mapk Pathway

Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study

2016 ◽  
Vol 30 ◽  
pp. 36-42 ◽  
Author(s):  
Fangfang Zhu ◽  
Lian Yin ◽  
Leilei Ji ◽  
Fan Yang ◽  
Guangji Zhang ◽  
...  
Keyword(s):  
Gouty Arthritis ◽  
In Vitro Study ◽  
Suppressive Effect ◽  
Cartilage Matrix ◽  
Vitro Study ◽  
Matrix Degradation

scholarly journals Inhibition of the p38 MAPK pathway sensitizes human gastric cells to doxorubicin treatment in vitro and in vivo

2014 ◽  
Vol 10 (6) ◽  
pp. 3275-3281 ◽  
Author(s):  
WEI TAN ◽  
HONG-GANG YU ◽  
HE-SHENG LUO
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
Doxorubicin Treatment ◽  
Gastric Cells ◽  
P38 Mapk Pathway

Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study

2006 ◽  
Vol 164 (3) ◽  
pp. 174-180 ◽  
Author(s):  
Mahaboobkhan Rasool ◽  
Palaninathan Varalakshmi
Keyword(s):  
Withania Somnifera ◽  
Gouty Arthritis ◽  
In Vitro Study ◽  
Suppressive Effect ◽  
Vitro Study

Suppressive effect of modified Simiaowan on experimental gouty arthritis: An in vivo and in vitro study

2013 ◽  
Vol 150 (3) ◽  
pp. 1038-1044 ◽  
Author(s):  
Le Shi ◽  
Li Xu ◽  
Yanhua Yang ◽  
Hengwen Song ◽  
Hongying Pan ◽  
...  
Keyword(s):  
Gouty Arthritis ◽  
In Vitro Study ◽  
Suppressive Effect ◽  
Vitro Study

scholarly journals FR167653 inhibits fibronectin expression and apoptosis in diabetic glomeruli and in high-glucose-stimulated mesangial cells

2008 ◽  
Vol 295 (2) ◽  
pp. F595-F604 ◽  
Author(s):  
Dong-Sub Jung ◽  
Jin Ji Li ◽  
Seung-Jae Kwak ◽  
Sun Ha Lee ◽  
Jehyun Park ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Protein Expression ◽  
P38 Mapk ◽  
High Glucose ◽  
Mesangial Cells ◽  
Mapk Pathway ◽  
P38 Mapk Pathway ◽  
Fibronectin Expression

Previous in vitro studies suggest that the p38 MAPK pathway may be involved in the pathogenesis of diabetic nephropathy, but the consequences of the inhibition of the p38 MAPK pathway have not been well elucidated in diabetic (DM) glomeruli. This study was undertaken to investigate the effect of p38 MAPK inhibitor, FR167653, on fibronectin expression and apoptosis in DM glomeruli and in high-glucose-stimulated mesangial cells (MC). In vivo, 32 Sprague-Dawley rats were injected with diluent (control, N = 16) or streptozotocin intraperitoneally (DM, N = 16). Eight rats from each group were treated with FR167653 for 3 mo. In vitro, rat MC were exposed to medium containing 5.6 mM glucose or 30 mM glucose [high glucose (HG)] with or without 10−6 M FR167653 for 24 h. Fibronectin mRNA and protein expression were determined by real-time PCR and Western blot, respectively. Western blot for apoptosis-related molecules, terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling assay, and Hoechst 33342 staining were performed to determine apoptosis. FR167653 ameliorated the increases in fibronectin-to-GAPDH mRNA ratio and protein expression in DM glomeruli by 89 and 79% and in HG-stimulated MC by 70 and 91%, respectively ( P < 0.05). Under diabetic conditions, Bcl-2 protein expression was decreased, whereas cleaved caspase-3 protein expression was increased ( P < 0.05), and these changes were inhibited by FR167653 treatment. Apoptotic cells were also significantly increased in DM glomeruli and in HG-stimulated MC ( P < 0.05), and FR167653 ameliorated these increases in apoptotic cells, both in vivo and in vitro. In conclusion, these findings suggest that the inhibition of the p38 MAPK pathway has a beneficial effect on the development of diabetic nephropathy by inhibiting the increase in fibronectin expression and apoptosis.

scholarly journals Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-κB and p38 MAPK pathway

2020 ◽  
Vol 10 (2) ◽  
pp. 130-146 ◽  
Author(s):  
Xiaoli Liang ◽  
Yuan Huang ◽  
Xiping Pan ◽  
Yanbing Hao ◽  
Xiaowei Chen ◽  
...  
Keyword(s):  
Erucic Acid ◽  
P38 Mapk ◽  
Influenza A Virus ◽  
Virus Replication ◽  
Influenza A ◽  
Mapk Pathway ◽  
Isatis Indigotica ◽  
P38 Mapk Pathway
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