Antidepressant discontinuation increases relapse risk for depressed patients in primary care

2021 ◽  
Vol 32 (12) ◽  
pp. 5-5

1994 ◽  
Vol 9 (9) ◽  
pp. 534-535 ◽  
Author(s):  
Edward H. Wagner ◽  
Michael VonKorff ◽  
Gregory E. Simon


Author(s):  
Mary Jo Dorsey ◽  
Ellen Detlefsen

Objective – To describe preliminary findings from a study of information-seeking behaviors of primary care physicians who care for elderly and depressed patients, and the correlation between what is sought versus what is provided to the patient and (or) caregiver. Setting – Physicians in two large ambulatory primary care practices throughout urban Pittsburgh, Pennsylvania, who take care of geriatric patients. Methods – Structured interviews, with common questions, will be conducted with 12 primary care physicians to determine patterns of information-seeking behaviors. Environmental scans of physicians' offices for evidence of their existing information behaviors will complement the information obtained from the interviews. Results – This pilot study provides an analysis of the resources primary care physicians use to seek information to provide to patients and caregivers. Analyses show types of information sought, time spent seeking information, and methods used to find information given to patients. Conclusions – With mounting evidence of the Internet being used for patient self care, it is essential to understand if primary care physicians understand the scope and breadth of information readily available to their patients. The primary care physician needs to be aware of the types of information made available to their patients and the caregivers who are inclined to obtain information for the patient.





2021 ◽  
Vol 5 (1) ◽  
pp. 22-35
Author(s):  
Farrah Lee Rosentreader

Background: Depression is highly prevalent in primary care settings and depressed patients of all ages are seen by their Primary Care Provider (PCP) for treatment (Datto et al., 2003).  In order to adequately treat depression, PCPs must follow the clinical guidelines for follow-up.Purpose: The purpose of this project was to implement a standardized follow-up plan for patients aged 12 and older with a positive screen for depression using the Patient Health Questionnaire (PHQ-9) screening tool.Methods: The setting was a rural clinic in Broken Bow, Nebraska.  The sample included 89 patients seen between September 1 -November 30, 2020 who met the criteria of a PHQ-9 score of 5 or greater compared with 47 patients seen between September 1 -November 30, 2019. Quantitative data was analyzed using descriptive statistics, frequency and means and compared between before and after implementation of this quality improvement project.Results: In 2019, 11.3 % of patients reported depression. That more than doubled to 25.6 % in 2020.  Of the depressed patients in 2019, 36.2% had mild depression, while the number almost doubled to 60.7% in 2020. The 2020 PHQ-9 results were reviewed from most severe down to mild depression.  Of the 35 patients with the highest severity, 89% had at least one measure completed representing an adequate follow-up plan.  Referral rates improved from 12.8% in 2019 to 14.6% in 2020.  Medication was the most common treatment in both years with 57.4% in 2019 and 27% in 2020.  Completed follow-ups improved from 45.5% in 2019 to 73% in 2020; with 1 nurse phone call follow-up and one CSSR-S completed.Conclusion: It is unknow the affects from the 2020 pandemic.  However, and increase in mild depression shows a need to know how to treat sub-threshold depression. The use of the template as a guide led to improvement on all measures. However, some measures were used only sparingly and use may be improved with increased acceptance of the guide.  



2016 ◽  
Vol 33 (S1) ◽  
pp. S422-S423
Author(s):  
P. Romero-Sanchiz ◽  
R. Nogueira-Arjona ◽  
F. Mayoral-Cleríes ◽  
F. Rivas-Guerrero ◽  
P. Araos-Gómez ◽  
...  

IntroductionEndocannabinoid system has been highlighted as one of the most relevant research topics by neurobiologists, pharmacists, basic scientists and clinicians. The association between endocannabinoids and its congeners and mood disorders is relatively recent. However, evidence from both clinical and preclinical studies is increasing and many researchers point out endocannabinoid system and particularly endocannabinoids and congeners as promising pharmacological targets.Aims and objectivesThe main objective of this study is to compare the plasma concentrations of endocannabinoids and congeners between a sample of patients with depression and a sample of control subjects, and the influence of variables such as age, body mass index, gender, severity of symptoms, and antidepressant medication.MethodPlasma concentrations of endocannabinoids and congeners will be analyzed in 69 patients with depression from primary care and 47 controls using mass spectrometry analysis.ResultsStatistically significant differences in 2-arachidonoylglycerol and monoacylglycerols were found between both samples. Somatic symptoms of depression seems to be more related to these compounds that to cognitive-affective symptoms. In addition, differences between mildly and moderately depressed patients were found in concentrations of AEA, LEA, DGLEA and POEA. Patients with antidepressant medication showed higher levels of 2-AG, DGLEA and OEA.ConclusionsThe results of this study provide evidence supporting the hypothesis that in depression there is a dysregulation of the inflammatory signaling and, consequently the immune system. The results of this study could also support the realization of translational research to better understand the mechanisms of this widely distributed system.Disclosure of interestThe authors have not supplied their declaration of competing interest.



2003 ◽  
Vol 18 (3) ◽  
pp. 133-141 ◽  
Author(s):  
Alan Wade ◽  
Gordon M Crawford ◽  
Margaret Angus ◽  
Richard Wilson ◽  
Lorna Hamilton




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