Theory of chemical bonds in metalloenzymes. IX. Theoretical study on the active site of the ribonucleotide reductase and the related species

2007 ◽  
Vol 107 (15) ◽  
pp. 3250-3265 ◽  
Author(s):  
Mitsuo Shoji ◽  
Hiroshi Isobe ◽  
Yu Takano ◽  
Yasutaka Kitagawa ◽  
Shusuke Yamanaka ◽  
...  
Keyword(s):  
Ribonucleotide Reductase ◽  
Active Site ◽  
Related Species ◽  
Theoretical Study ◽  
Chemical Bonds ◽  
Theory Of Chemical Bonds

scholarly journals Sirtuin inhibitor sirtinol is an intracellular iron chelator

2015 ◽  
Vol 51 (24) ◽  
pp. 5104-5107 ◽  
Author(s):  
R. Gautam ◽  
E. A. Akam ◽  
A. V. Astashkin ◽  
J. J. Loughrey ◽  
E. Tomat
Keyword(s):  
Ribonucleotide Reductase ◽  
Active Site ◽  
Iron Chelator ◽  
Intracellular Iron

Known as an inhibitor of sirtuin deacetylases, sirtinol binds intracellular iron and perturbs the active site of iron-dependent enzyme ribonucleotide reductase.

Theory of chemical bonds in metalloenzymes II: Hybrid-DFT studies in iron-sulfur clusters

2005 ◽  
Vol 105 (6) ◽  
pp. 628-644 ◽  
Author(s):  
M. Shoji ◽  
K. Koizumi ◽  
Y. Kitagawa ◽  
S. Yamanaka ◽  
T. Kawakami ◽  
...  
Keyword(s):  
Chemical Bonds ◽  
Dft Studies ◽  
Iron Sulfur Clusters ◽  
Iron Sulfur ◽  
Theory Of Chemical Bonds

scholarly journals Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase

2014 ◽  
Vol 136 (46) ◽  
pp. 16210-16216 ◽  
Author(s):  
Lisa Olshansky ◽  
Arturo A. Pizano ◽  
Yifeng Wei ◽  
JoAnne Stubbe ◽  
Daniel G. Nocera
Keyword(s):  
Hydrogen Atom ◽  
Ribonucleotide Reductase ◽  
Active Site ◽  
Hydrogen Atom Abstraction ◽  
Thiyl Radical ◽  
Kinetics Of
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