Determination of specific volatile organic compounds synthesised during Tuber borchii fruit body development by solid-phase microextraction and gas chromatography/mass spectrometry

2003 ◽  
Vol 18 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Sabrina Zeppa ◽  
Anna Maria Gioacchini ◽  
Chiara Guidi ◽  
Michele Guescini ◽  
Raffaella Pierleoni ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Fruit Body ◽  
Gas Chromatography Mass Spectrometry ◽  
Tuber Borchii ◽  
Body Development ◽  
Volatile Organic ◽  
Fruit Body Development

scholarly journals Determination of VOCs in Surgical Resected Tissues from Colorectal Cancer Patients by Solid Phase Microextraction Coupled to Gas Chromatography–Mass Spectrometry

2021 ◽  
Vol 11 (15) ◽  
pp. 6910
Author(s):  
Nicoletta De Vietro ◽  
Antonella Maria Aresta ◽  
Arcangelo Picciariello ◽  
Maria Teresa Rotelli ◽  
Carlo Zambonin
Keyword(s):  
Colorectal Cancer ◽  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Cancer Patients ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Organic ◽  
Colorectal Cancer Patients

Early diagnosis of colorectal cancer is crucial to increase the survival rates of the patients and breath analysis represents a promising non-invasive tool to obtain information on cancer-related variations on the human volatilome. A solid phase microextraction coupled to gas chromatography–mass spectrometry method for the determination of seven selected compounds, representative of the volatilome secreted by the colonic mucosa of patients affected by colorectal cancer, including benzaldehyde, benzoic acid, dodecane, ethylbenzene, octanal, tetradecane and toluene, was developed. All the extraction parameters were studied for both headspace and direct immersion sampling and the procedures fully validated. The potential of the approach was demonstrated by the time monitoring of the emission of the selected volatile organic compounds from the surgical resected colon mucosa tissues of colorectal cancer patients. Furthermore, the extraction and identification of thirty-one volatile organic compounds secreted by the same tissues was accomplished.

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