Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1′-hydroxylation kinetics in human liver microsomes

Rick C. Steenwyk; J. Matthew Hutzler; Jim Sams; Zhouxin Shen; Gary Siuzdak

doi:10.1002/rcm.2796

Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1′-hydroxylation kinetics in human liver microsomes

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2796 ◽

2006 ◽

Vol 20 (24) ◽

pp. 3717-3722 ◽

Cited By ~ 7

Author(s):

Rick C. Steenwyk ◽

J. Matthew Hutzler ◽

Jim Sams ◽

Zhouxin Shen ◽

Gary Siuzdak

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Rat Plasma ◽

Human Liver Microsomes ◽

Ion Trap Mass Spectrometry ◽

Desorption Ionization

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In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry

Journal of Separation Science ◽

10.1002/jssc.201101094 ◽

2012 ◽

Vol 35 (9) ◽

pp. 1102-1109 ◽

Cited By ~ 9

Author(s):

Hye Young Ji ◽

Hyeri Lee ◽

Jeong-Han Kim ◽

Ki Hyun Kim ◽

Kang Ro Lee ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Ion Trap Mass Spectrometry

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Application of liquid chromatography–electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes

Journal of Chromatography B ◽

10.1016/s1570-0232(03)00484-7 ◽

2003 ◽

Vol 794 (2) ◽

pp. 303-310 ◽

Cited By ~ 17

Author(s):

Chandrani Gunaratna ◽

Tianyi Zhang

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Ionization ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Ion Trap Mass Spectrometry

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Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.1891 ◽

2005 ◽

Vol 19 (8) ◽

pp. 1069-1074 ◽

Cited By ~ 10

Author(s):

E. Kantharaj ◽

Peter B. Ehmer ◽

An Tuytelaars ◽

Anne Van Vlaslaer ◽

Claire Mackie ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Simultaneous Measurement ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Metabolite Identification ◽

Human Liver Microsomes ◽

Metabolic Stability ◽

Ion Trap Mass Spectrometry

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Application of Isotopic Ratio Mass Spectrometry for the in Vitro Determination of Demethylation Activity in Human Liver Microsomes Using N-methyl-13C-Labeled Substrates

Analytical Biochemistry ◽

10.1006/abio.2002.5701 ◽

2002 ◽

Vol 306 (2) ◽

pp. 181-187 ◽

Cited By ~ 5

Author(s):

Florence Grand ◽

Izzet Kilinc ◽

Albert Sarkis ◽

Jérôme Guitton

Keyword(s):

Mass Spectrometry ◽

Human Liver ◽

Isotopic Ratio ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Demethylation Activity

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Generation of Highly Charged Peptide and Protein Ions by Atmospheric Pressure Matrix-Assisted Infrared Laser Desorption/Ionization Ion Trap Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac070628t ◽

2007 ◽

Vol 79 (14) ◽

pp. 5484-5488 ◽

Cited By ~ 31

Author(s):

Simone König ◽

Oliver Kollas ◽

Klaus Dreisewerd

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Ion Trap ◽

Laser Desorption ◽

Infrared Laser ◽

Ion Trap Mass Spectrometry ◽

Laser Desorption Ionization ◽

Desorption Ionization ◽

Protein Ions

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HPLC-UV Atmospheric Pressure Ionization Mass Spectrometry Determination of the Dopamine D2 Agonist N-0923 and Its Major Metabolites After Oxidative Metabolism by Rat-, Monkey-, and Human Liver Microsomes

Toxicology Methods ◽

10.3109/15376519309068445 ◽

1993 ◽

Vol 3 (4) ◽

pp. 279-290 ◽

Cited By ~ 8

Author(s):

P. J. Swart ◽

G. M. Bronner ◽

A. P. Bruins ◽

K. Ensing ◽

P. G. Tepper ◽

...

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Human Liver ◽

Liver Microsomes ◽

Ionization Mass ◽

Atmospheric Pressure Ionization ◽

D2 Agonist ◽

Dopamine D2 Agonist ◽

Pressure Ionization Mass Spectrometry

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Atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry of sulfonic acid derivatized tryptic peptides

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.499 ◽

2001 ◽

Vol 15 (23) ◽

pp. 2227-2239 ◽

Cited By ~ 29

Author(s):

T. Keough ◽

M. P. Lacey ◽

R. J. Strife

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Sulfonic Acid ◽

Ion Trap ◽

Laser Desorption ◽

Ion Trap Mass Spectrometry ◽

Laser Desorption Ionization ◽

Desorption Ionization ◽

Matrix Assisted Laser ◽

Matrix Assisted Laser Desorption

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Quantitation of Lysergic Acid Diethylamide in Urine Using Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Ion Trap Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac049285e ◽

2004 ◽

Vol 76 (23) ◽

pp. 7143-7148 ◽

Cited By ~ 20

Author(s):

Meng Cui ◽

Margaret A. McCooeye ◽

Catharine Fraser ◽

Zoltán Mester

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Ion Trap ◽

Laser Desorption ◽

Lysergic Acid ◽

Ion Trap Mass Spectrometry ◽

Laser Desorption Ionization ◽

Desorption Ionization ◽

Matrix Assisted Laser ◽

Matrix Assisted Laser Desorption

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Determination of triclosan metabolites by using in-source fragmentation from high-performance liquid chromatography/negative atmospheric pressure chemical ionization ion trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4558 ◽

2010 ◽

Vol 24 (13) ◽

pp. 1828-1834 ◽

Cited By ~ 34

Author(s):

Jian-lin Wu ◽

Jie Liu ◽

Zongwei Cai

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

High Performance ◽

Chemical Ionization ◽

Ion Trap ◽

Atmospheric Pressure Chemical Ionization ◽

Ion Trap Mass Spectrometry ◽

Pressure Chemical Ionization ◽

Pressure Chemical

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Ion suppression in the determination of clenbuterol in urine by solid-phase extraction atmospheric pressure chemical ionisation ion-trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.908 ◽

2002 ◽

Vol 17 (3) ◽

pp. 245-250 ◽

Cited By ~ 50

Author(s):

M. W. J. van Hout ◽

H. A. G. Niederländer ◽

R. A. de Zeeuw ◽

G. J. de Jong

Keyword(s):

Mass Spectrometry ◽

Solid Phase Extraction ◽

Atmospheric Pressure ◽

Ion Trap ◽

Solid Phase ◽

Ion Trap Mass Spectrometry ◽

Phase Extraction ◽

Pressure Chemical ◽

Chemical Ionisation

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