Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry

E. Kantharaj; Peter B. Ehmer; An Tuytelaars; Anne Van Vlaslaer; Claire Mackie; Ron A. H. J. Gilissen

doi:10.1002/rcm.1891

Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.1891 ◽

2005 ◽

Vol 19 (8) ◽

pp. 1069-1074 ◽

Cited By ~ 10

Author(s):

E. Kantharaj ◽

Peter B. Ehmer ◽

An Tuytelaars ◽

Anne Van Vlaslaer ◽

Claire Mackie ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Simultaneous Measurement ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Metabolite Identification ◽

Human Liver Microsomes ◽

Metabolic Stability ◽

Ion Trap Mass Spectrometry

Download Full-text

In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry

Journal of Separation Science ◽

10.1002/jssc.201101094 ◽

2012 ◽

Vol 35 (9) ◽

pp. 1102-1109 ◽

Cited By ~ 9

Author(s):

Hye Young Ji ◽

Hyeri Lee ◽

Jeong-Han Kim ◽

Ki Hyun Kim ◽

Kang Ro Lee ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Ion Trap Mass Spectrometry

Download Full-text

Application of liquid chromatography–electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes

Journal of Chromatography B ◽

10.1016/s1570-0232(03)00484-7 ◽

2003 ◽

Vol 794 (2) ◽

pp. 303-310 ◽

Cited By ~ 17

Author(s):

Chandrani Gunaratna ◽

Tianyi Zhang

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Ionization ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Ion Trap Mass Spectrometry

Download Full-text

Characterization of metabolites of a novel histamine H2-receptor antagonist, lafutidine, in human liver microsomes by liquid chromatography coupled with ion trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3558 ◽

2008 ◽

Vol 22 (12) ◽

pp. 1843-1852 ◽

Cited By ~ 7

Author(s):

Yuya Wang ◽

Xiaoyan Chen ◽

Qiang Li ◽

Dafang Zhong

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Ion Trap Mass Spectrometry ◽

H2 Receptor Antagonist ◽

Histamine H2 Receptor ◽

Histamine H2 Receptor Antagonist

Download Full-text

P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes 1 1Abbreviations: FTI, farnesyl-protein transferase inhibitor; FTase, farnesyl-protein transferase; and LC-MS, liquid chromatography-mass spectrometry.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00724-9 ◽

2001 ◽

Vol 62 (6) ◽

pp. 773-776 ◽

Cited By ~ 15

Author(s):

Masato Chiba ◽

Cuyue Tang ◽

William E Neway ◽

Theresa M Williams ◽

S Jane Desolms ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Metabolic Stability ◽

Liquid Chromatography Mass Spectrometry ◽

Inhibitory Potency ◽

Farnesyl Protein Transferase ◽

Binding Spectra

Download Full-text

Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1′-hydroxylation kinetics in human liver microsomes

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2796 ◽

2006 ◽

Vol 20 (24) ◽

pp. 3717-3722 ◽

Cited By ~ 7

Author(s):

Rick C. Steenwyk ◽

J. Matthew Hutzler ◽

Jim Sams ◽

Zhouxin Shen ◽

Gary Siuzdak

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Rat Plasma ◽

Human Liver Microsomes ◽

Ion Trap Mass Spectrometry ◽

Desorption Ionization

Download Full-text

Study of the in vitro metabolic profile of a new α2-adrenergic agonist in rat and human liver microsomes by using liquid chromatography-multiple-stage mass spectrometry and nuclear magnetic resonance

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2019.03.067 ◽

2019 ◽

Vol 172 ◽

pp. 67-77

Author(s):

Josiane de O. Cardoso ◽

Bianca F. da Silva ◽

Tiago Venâncio ◽

Marina G. da Rocha Pitta ◽

Ivan da R. Pitta ◽

...

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Human Liver ◽

Metabolic Profile ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Adrenergic Agonist

Download Full-text

Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2014.03.030 ◽

2014 ◽

Vol 97 ◽

pp. 65-71 ◽

Cited By ~ 20

Author(s):

Lin Yuan ◽

Peipei Jia ◽

Yupeng Sun ◽

Chengcheng Zhao ◽

Xuran Zhi ◽

...

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Cytochrome P450 Enzymes

Download Full-text

Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.114.063016 ◽

2015 ◽

Vol 43 (7) ◽

pp. 1137-1146 ◽

Cited By ~ 15

Author(s):

Boram Lee ◽

Hyeon-Kyeong Ji ◽

Taeho Lee ◽

Kwang-Hyeon Liu

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

In vitro metabolism of BYZX in human liver microsomes and the structural elucidation of metabolite by liquid chromatography–mass spectrometry method

Journal of Chromatography B ◽

10.1016/j.jchromb.2007.07.029 ◽

2007 ◽

Vol 857 (2) ◽

pp. 266-274 ◽

Cited By ~ 11

Author(s):

Zong-ling Xia ◽

Jing-yan Ying ◽

Rong Sheng ◽

Su Zeng ◽

Yong-zhou Hu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Spectrometry Method ◽

Mass Spectrometry Method

Download Full-text

Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3220 ◽

2007 ◽

Vol 21 (20) ◽

pp. 3317-3322 ◽

Cited By ~ 16

Author(s):

Hai-Zhi Bu ◽

Ping Zhao ◽

Deepak K. Dalvie ◽

William F. Pool

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text