On a new piecewise regression model with cure rate: Diagnostics and application to medical data

2021 ◽  
Author(s):  
Yolanda M. Gómez ◽  
Diego I. Gallardo ◽  
Jeremias Leão ◽  
Vinicius F. Calsavara
2008 ◽  
Vol 23 (4) ◽  
pp. 251-259 ◽  
Author(s):  
Theodora Bejan-Angoulvant ◽  
Anne-Marie Bouvier ◽  
Nadine Bossard ◽  
Aurelien Belot ◽  
Valérie Jooste ◽  
...  

Author(s):  
JING-RUNG YU ◽  
GWO-HSHIUNG TZENG

This study proposes fuzzy multiple objective programming to determine the measure of fitness and the number of change-points in an interval piecewise regression model. To increase the measure of fitness, Tanaka and Lee proposed a conceptual procedure, which is a heuristic approach and becomes complicated for determining the proper polynomial. Therefore, a multiple objective approach is adopted to obtain a compromise solution among three objectives — maximizing the measure of fitness, minimizing the number of change-points and minimizing the width to obtain the interval regression models. By using the proposed method, a better measure of fitness can be obtained. Two numerical examples are used as demonstrations to illustrate our approach in more detail.


2017 ◽  
Vol 27 (11) ◽  
pp. 3207-3223 ◽  
Author(s):  
Thiago G Ramires ◽  
Gauss M Cordeiro ◽  
Michael W Kattan ◽  
Niel Hens ◽  
Edwin MM Ortega

Cure fraction models are useful to model lifetime data with long-term survivors. We propose a flexible four-parameter cure rate survival model called the log-sinh Cauchy promotion time model for predicting breast carcinoma survival in women who underwent mastectomy. The model can estimate simultaneously the effects of the explanatory variables on the timing acceleration/deceleration of a given event, the surviving fraction, the heterogeneity, and the possible existence of bimodality in the data. In order to examine the performance of the proposed model, simulations are presented to verify the robust aspects of this flexible class against outlying and influential observations. Furthermore, we determine some diagnostic measures and the one-step approximations of the estimates in the case-deletion model. The new model was implemented in the generalized additive model for location, scale and shape package of the R software, which is presented throughout the paper by way of a brief tutorial on its use. The potential of the new regression model to accurately predict breast carcinoma mortality is illustrated using a real data set.


Author(s):  
JING-RUNG YU ◽  
GWO-HSHIUNG TZENG ◽  
HAN-LIN LI

To handle large variation data, an interval piecewise regression method with automatic change-point detection by quadratic programming is proposed as an alternative to Tanaka and Lee's method. Their unified quadratic programming approach can alleviate the phenomenon where some coefficients tend to become crisp in possibilistic regression by linear programming and also obtain the possibility and necessity models at one time. However, that method can not guarantee the existence of a necessity model if a proper regression model is not assumed especially with large variations in data. Using automatic change-point detection, the proposed method guarantees obtaining the necessity model with better measure of fitness by considering variability in data. Without piecewise terms in estimated model, the proposed method is the same as Tanaka and Lee's model. Therefore, the proposed method is an alternative method to handle data with the large variations, which not only reduces the number of crisp coefficients of the possibility model in linear programming, but also simultaneously obtains the fuzzy regression models, including possibility and necessity models with better fitness. Two examples are presented to demonstrate the proposed method.


Entropy ◽  
2021 ◽  
Vol 23 (11) ◽  
pp. 1517
Author(s):  
Hao Yang Teng ◽  
Zhengjun Zhang

Logistic regression is widely used in the analysis of medical data with binary outcomes to study treatment effects through (absolute) treatment effect parameters in the models. However, the indicative parameters of relative treatment effects are not introduced in logistic regression models, which can be a severe problem in efficiently modeling treatment effects and lead to the wrong conclusions with regard to treatment effects. This paper introduces a new enhanced logistic regression model that offers a new way of studying treatment effects by measuring the relative changes in the treatment effects and also incorporates the way in which logistic regression models the treatment effects. The new model, called the Absolute and Relative Treatment Effects (AbRelaTEs) model, is viewed as a generalization of logistic regression and an enhanced model with increased flexibility, interpretability, and applicability in real data applications than the logistic regression. The AbRelaTEs model is capable of modeling significant treatment effects via an absolute or relative or both ways. The new model can be easily implemented using statistical software, with the logistic regression model being treated as a special case. As a result, the classical logistic regression models can be replaced by the AbRelaTEs model to gain greater applicability and have a new benchmark model for more efficiently studying treatment effects in clinical trials, economic developments, and many applied areas. Moreover, the estimators of the coefficients are consistent and asymptotically normal under regularity conditions. In both simulation and real data applications, the model provides both significant and more meaningful results.


2005 ◽  
Vol 6 (6) ◽  
pp. 256-261
Author(s):  
Young-Don Ko ◽  
Kil-Han Kim ◽  
Il-Gu Yun ◽  
Kyu-Bok Lee ◽  
Jong-Kyu Kim

2018 ◽  
Vol 37 (29) ◽  
pp. 4421-4440 ◽  
Author(s):  
Jeremias Leão ◽  
Víctor Leiva ◽  
Helton Saulo ◽  
Vera Tomazella
Keyword(s):  

2018 ◽  
Vol 11 (1) ◽  
pp. 6 ◽  
Author(s):  
Amanda D’Andrea ◽  
Ricardo Rocha ◽  
Vera Tomazella ◽  
Francisco Louzada

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