Planning a reproducibility study: how many subjects and how many replicates per subject for an expected width of the 95 per cent confidence interval of the intraclass correlation coefficient

2001 ◽  
Vol 20 (21) ◽  
pp. 3205-3214 ◽  
Author(s):  
B. Giraudeau ◽  
J. Y. Mary
Keyword(s):  
Confidence Interval ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Reproducibility Study ◽  
Expected Width

Speech perception, real-ear measurements and self-perceived hearing impairment after remote and face-to-face programming of hearing aids: A randomized single-blind agreement study

2019 ◽  
pp. 1357633X1988354 ◽  
Author(s):  
Frederic Venail ◽  
Marie C Picot ◽  
Gregory Marin ◽  
Sylvain Falinower ◽  
Jacques Samson ◽  
...  
Keyword(s):  
Speech Perception ◽  
Confidence Interval ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Hearing Aids ◽  
Hearing Aid ◽  
Intraclass Correlation ◽  
Speech Understanding ◽  
Face To Face ◽  
Single Blind

Introduction Current literature does not provide strong evidence that remote programming of hearing aids is effective, despite its increasing use by audiologists. We tested speech perception outcomes, real-ear insertion gain, and changes in self-perceived hearing impairment after face-to-face and remote programming of hearing aids in a randomized multicentre, single-blind crossover study. Methods Adult experienced hearing aid users were enrolled during routine follow-up visits to audiology clinics. Hearing aids were programmed both face to face and remotely, then participants randomly received either the face-to-face or remote settings in a blinded manner and were evaluated 5 weeks later. Participants then received the other settings and were evaluated 5 weeks later. Results Data from 52 out of 60 participants were analysed. We found excellent concordance in performance of hearing aids programmed face to face and remotely for speech understanding in quiet (phonetically balanced kindergarten test – intraclass correlation coefficient of 0.92 (95% confidence interval: 0.87–0.95)), and good concordance in performance for speech understanding in noise (phonetically balanced kindergarten +5 dB signal-to-noise ratio – intraclass correlation coefficient of 0.71 (95% confidence interval: 0.55–0.82)). Face-to-face and remote programming took 10 minutes (±2.9) and 10 minutes (±2.8), respectively. Real-ear insertion gains were highly correlated for input sound at 50, 65 and 80 dB sound pressure levels. The programming type did not affect the abbreviated profile of hearing aid questionnaire scores. Conclusions In experienced hearing aid users, face-to-face and remote programming of hearing aids give similar results in terms of speech perception, with no increase in the time spent on patients’ care and no difference in self-reported hearing benefit. ClinicalTrials.gov Identifier NCT02589561

scholarly journals Intra- and inter-rater reliability in a comparative study of cross-sectional and spiral computed tomography pelvimetry methods

2019 ◽  
Vol 8 (6) ◽  
pp. 205846011985518 ◽  
Author(s):  
Erika Phexell ◽  
Anna Åkesson ◽  
Marcus Söderberg ◽  
Anetta Bolejko
Keyword(s):  
Computed Tomography ◽  
Radiation Dose ◽  
Confidence Interval ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Measurement Reliability ◽  
Cross Sectional ◽  
Rater Reliability ◽  
Short Spiral

Background Different low-dose computed tomography (CT) pelvimetry methods can be used to evaluate the size of birth canal before delivery. CT pelvimetry might generate an acceptable low fetal radiation dose but its measurement accuracy is unknown. Purpose To investigate intra- and inter-rater measurement reliability of cross-sectional and two spiral CT pelvimetry methods: standard spiral and short spiral. Material and Methods Ten individuals (age ≥60 years, body mass index ≥30 kg/m2) having a CT scan of the abdomen also had CT pelvimetry scans. Three radiologists made independent measurements of each pelvimetry method on two occasions and also in consensus for a reference pelvimetry computed from the standard-dose CT scan of the abdomen. Inter- and intra-rater reliability was analyzed by intraclass correlation coefficient. Results Measurements in the short spiral pelvimetry demonstrated excellent intra- and inter-rater reliability, intraclass correlation coefficient ≥0.93, and good to excellent 95% confidence interval 0.87–0.99. Corresponding results of the standard spiral and cross-sectional pelvimetry showed good to excellent intraclass correlation coefficient ≥0.85 and ≥0.76, and 95% confidence interval was least good and moderate 0.73–0.98 and 0.59–0.97, respectively. Intraclass correlation coefficient between reference pelvimetry and other CT methods showed analogous results. Conclusion The short spiral pelvimetry demonstrated high and best reliability in comparison to other methods. Standard spiral method showed also good measurement reliability but the short spiral pelvimetry generates lower fetal radiation dose. This method might be suitable for measurements at narrow pelvis. Patient acceptance and attitude to CT pelvimetry should be investigated.

scholarly journals Intra and Interobserver Variability in the B-mode Transorbital Sonographic Measurement of the Optic Nerve Sheath Diameter in Healthy Nepalese Individuals

2019 ◽  
Vol 9 (1) ◽  
pp. 18-23
Author(s):  
Prasanna Ghimire ◽  
Birendra Bahadur Chand ◽  
Yug Bijay Mahat ◽  
Subash Ojha ◽  
Bhuwaneshwar Prasad Singh
Keyword(s):  
Optic Nerve ◽  
Confidence Interval ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Interobserver Variability ◽  
Intraclass Correlation ◽  
Optic Nerve Sheath Diameter ◽  
Ultrasound Measurement ◽  
Nerve Sheath ◽  
Ocular Ultrasound

Introduction: Ocular ultrasound has gained importance as a non-invasive imaging technique in the screening, diagnosis and treatment management of intracranial hypertension. The aim of our study was to estimate the intra and interobserver variability on B-mode ocular ultrasound measurement of optic nerve sheath diameter (ONSD). Methods: ONSD of the right eye was measured by ultrasound examination among 120 healthy adult volunteers. The ONSD was assessed 3 mm behind the globe and two serial measurements were taken by two observers who were blinded to each other’s findings. Results: Age of the volunteers ranged from 18 to 27 years with a mean age of 23.07 +/- SD of 2.486. The mean of ONSDs of two observers was 4.168 +/- SD of 0.54 mm. The intraclass correlation coefficient for first and second observers was 0.997 and 0.978 respectively at 95% confidence interval. The interobserver intraclass correlation coefficient was 0.977 at 95% confidence interval. No correlation of age and gender was noted with ONSD. Conclusions: B-mode transorbital ultrasound measurement of ONSD is highly reproducible with significant intra-observer and inter-observer agreement. Ultrasound measurement of ONSD measurements can serve as indispensable tool in critical care.

Intraobserver reproducibility and interobserver agreement of demarcation line depth measurements following corneal cross linking

2019 ◽  
Vol 30 (4) ◽  
pp. 635-642
Author(s):  
Argyrios Tzamalis ◽  
Riccardo Vinciguerra ◽  
Vito Romano ◽  
Esmaeil Arbabi ◽  
Mark Batterbury ◽  
...  
Keyword(s):  
Medical Students ◽  
Confidence Interval ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Cross Linking ◽  
Demarcation Line ◽  
Line Depth ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Purpose: The aim of this study was to evaluate the intraobserver reproducibility of demarcation line depth measurement in keratoconic patients after epithelium-off corneal collagen cross linking and assess the interobserver variability/agreement among examiners of various experience levels. Methods: 56 eyes of 56 patients undergoing corneal collagen cross linking for progressive keratoconus were enrolled. After 4 weeks, all patients underwent an anterior segment optical coherence tomography (AS-OCT; CASIA SS-1000; Tomey, Nagoya, Japan) in the cross-linked eye by four masked examiners (two medical students (S1 and S2) and two corneal fellows (F1 and F2)) in order to identify and measure the demarcation line depth in experienced and non-experienced users. The intraclass correlation coefficient and the coefficient of variation were calculated. Agreement between raters was evaluated using Bland–Altman plots, intraclass correlation coefficient and weighted-kappa statistics comparing raters in pairs. Results: The average demarcation line depth of all measurements was 254.34 ± 72.3 μm, varying from 84 to 459 μm. The intraclass correlation coefficient evaluating the reproducibility of measurements for F1 was 0.9379 (95% confidence interval (CI) =0.9035–0.9619), for the second (F2), it was 0.9837 (95% confidence interval = 0.9743–0.9901), while intraclass correlation coefficient between medical students was calculated 0.844. The overall intraclass correlation coefficient among all four observers was 0.8706 (95% confidence interval = 0.8061–0.9185). The coefficient of variation for repeated measurements was 5.981 μm (95% confidence interval = 3.966–7.471) and 3.312 μm (95% confidence interval = 2.468–3.981) for F1 and F2 raters, respectively. The percentage of demarcation line detection was 90.32%. Conclusion: The reproducibility of demarcation line measures although very good (intraclass correlation coefficient > 0.9), yielded a difference between the two experienced raters. Furthermore, the novice raters did not reach an excellent level of agreement with the expert ones showing greater variability in their recordings.

Sign in / Sign up

Export Citation Format

Share Document