Dispersive liquid–liquid microextraction based on solidification of floating organic drop: Determination of nonsteroidal anti‐inflammatory drugs in water

2021 ◽  
Author(s):  
Faady Siouri ◽  
Feras Abujaber ◽  
Asem Mubarak ◽  
Fuad Al‐Rimawi
Keyword(s):  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Rapid analysis of non-steroidal anti-inflammatory drugs in tap water and drinks by ionic liquid dispersive liquid–liquid microextraction coupled to ultra-high performance supercritical fluid chromatography

2014 ◽  
Vol 6 (18) ◽  
pp. 7294-7304 ◽  
Author(s):  
Yu Ji ◽  
Zhenxia Du ◽  
Haojie Zhang ◽  
Yun Zhang
Keyword(s):  
Ionic Liquid ◽  
Supercritical Fluid ◽  
High Performance ◽  
Tap Water ◽  
Rapid Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

A novel rapid analytical method for the determination of four non-steroidal anti-inflammatory drugs (NSAIDs) – nabumetone, ibuprofen, naproxen and diclofenac – in tap water and drinks is presented.

Optimized miniaturized air-assisted liquid–liquid microextraction for determination of non-steroidal anti-inflammatory drugs in bio-fluid samples

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 109473-109484 ◽  
Author(s):  
Alireza Asghari ◽  
Forough Khanalipoor ◽  
Behruz Barfi ◽  
Maryam Rajabi
Keyword(s):  
Simultaneous Extraction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Liquid Microextraction

A miniaturized air-assisted liquid–liquid microextraction method was developed for the simultaneous extraction of amlodipine, atorvastatin, and ibuprofen in some human bio-fluid samples prior to their determination using HPLC.

scholarly journals Simultaneous Determination of Four Nonsteroidal Anti-Inflammatory Drugs and Three Estrogen Steroid Hormones in Wastewater Samples by Dispersive Liquid–Liquid Microextraction Based on Solidification of Floating Organic Droplet and HPLC

2020 ◽  
Vol 103 (2) ◽  
pp. 392-398 ◽  
Author(s):  
Mihail Simion Beldean-Galea ◽  
Romain Klein ◽  
Maria-Virginia Coman
Keyword(s):  
Steroid Hormones ◽  
Treatment Plant ◽  
Enrichment Factors ◽  
Human Beings ◽  
Extraction Solvent ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Wastewater Samples ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Abstract Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and estrogen steroid hormones (estrogens) are pharmaceuticals intensively studied in environmental analysis due to their toxic effect on animal and human beings. Objective: Development of a simple, fast, and sensitive extraction method for the simultaneously analysis of four NSAIDs (ketoprofen, naproxen, ibuprofen, and diclofenac) and three estrogens (17ß-estradiol, 17α-ethynylestradiol, and estriol) from wastewater samples. Method: Dispersive liquid–liquid microextraction based on solidification of floating organic droplet followed by HPLC analysis with UV detection was developed. The influence of the main extraction parameters, e.g., the volume of extraction solvent and of disperser, the pH, and the ionic strength of sample were evaluated. Results: Good resolutions between the selected drugs were obtained using a reverse-phase column and a mobile phase of acetonitrile and water. This method provides good linearity (r > 0.999) in a concentration range of 1–100 µg/mL, good intra- and inter-day precision (RSD <7%) and low LOQs. The obtained enrichment factors were ranged between 162 and 180 for NSAIDs and between 118 and 185 for estrogens. The relative recoveries were situated >80% for all analysed drugs, except estriol (59%) both in synthetic and real wastewater samples. Conclusions: The developed method has been successfully applied for the analysis of the selected drugs in wastewater samples collected from the influent of a wastewater treatment plant. Highlights: Four NSAIDs and three estrogens from wastewater samples were simultaneously extracted and analysed using only 10 mL of sample and 50 μL of extraction solvent.

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