scholarly journals Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest

Stem Cells ◽  
2020 ◽  
Vol 38 (5) ◽  
pp. 613-623
Author(s):  
Suveg Pandey ◽  
Kelly M. Banks ◽  
Ritu Kumar ◽  
Andrew Kuo ◽  
Duancheng Wen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Cycle Arrest ◽  
Sphingosine Kinases

p53-independent DNA repair and cell cycle arrest in embryonic stem cells

FEBS Letters ◽  
1998 ◽  
Vol 425 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Sandrine Prost ◽  
Christopher O.C Bellamy ◽  
Alan R Clarke ◽  
Andrew H Wyllie ◽  
David J Harrison
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dna Repair ◽  
Embryonic Stem Cells ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Cycle Arrest

scholarly journals p53-Independent Cell Cycle and Erythroid Differentiation Defects in Murine Embryonic Stem Cells Haploinsufficient for Diamond Blackfan Anemia-Proteins: RPS19 versus RPL5

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89098 ◽  
Author(s):  
Sharon A. Singh ◽  
Tracie A. Goldberg ◽  
Adrianna L. Henson ◽  
Sehba Husain-Krautter ◽  
Abdallah Nihrane ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Erythroid Differentiation ◽  
Diamond Blackfan Anemia ◽  
Murine Embryonic Stem Cells

scholarly journals Developmental Acquisition of p53 Functions

2021 ◽  
Author(s):  
Sushil K. Jaiswal ◽  
Sonam Raj ◽  
Melvin L. DePamphilis
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Mammalian Development ◽  
Cycle Arrest ◽  
Expression Of Genes ◽  
Disparate Data ◽  
The Guardian

Abstract: Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not essential for mammalian development. Moreover, efforts to identify p53‑dependent developmental events have produced contradictory conclusions. Given the importance of pluripotent stem cells as models of mammalian development, and their applications in regenerative medicine and disease, resolving these conflicts is essential. Here we attempt to reconcile disparate data into justifiable conclusions predicated on reports that p53‑dependent transcription is first detected in late mouse blastocysts, that p53 activity first becomes potentially lethal during gastrulation, and that apoptosis does not depend on p53. Furthermore, p53 does not regulate expression of genes required for pluripotency in embryonic stem cells (ESCs); it contributes to ESC genomic stability and differentiation. Depending on conditions, p53 accelerates initiation of apoptosis in ESCs in response to DNA damage, but cell cycle arrest as well as the rate and extent of apoptosis in ESCs are p53-independent. In embryonic fibroblasts, p53 induces cell cycle arrest to allow repair of DNA damage, and cell senescence to prevent proliferation of cells with extensive damage.

scholarly journals Developmental Acquisition of p53 Functions

Genes ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1675
Author(s):  
Sushil Jaiswal ◽  
Sonam Raj ◽  
Melvin DePamphilis
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Mammalian Development ◽  
Cycle Arrest ◽  
Expression Of Genes ◽  
Disparate Data ◽  
The Guardian

Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not essential for mammalian development. Moreover, efforts to identify p53dependent developmental events have produced contradictory conclusions. Given the importance of pluripotent stem cells as models of mammalian development, and their applications in regenerative medicine and disease, resolving these conflicts is essential. Here we attempt to reconcile disparate data into justifiable conclusions predicated on reports that p53dependent transcription is first detected in late mouse blastocysts, that p53 activity first becomes potentially lethal during gastrulation, and that apoptosis does not depend on p53. Furthermore, p53 does not regulate expression of genes required for pluripotency in embryonic stem cells (ESCs); it contributes to ESC genomic stability and differentiation. Depending on conditions, p53 accelerates initiation of apoptosis in ESCs in response to DNA damage, but cell cycle arrest as well as the rate and extent of apoptosis in ESCs are p53-independent. In embryonic fibroblasts, p53 induces cell cycle arrest to allow repair of DNA damage, and cell senescence to prevent proliferation of cells with extensive damage.

scholarly journals Cycle arrest and aneuploidy induced by zidovudine in murine embryonic stem cells

Mutagenesis ◽  
2012 ◽  
Vol 27 (4) ◽  
pp. 431-436 ◽  
Author(s):  
P. B. Campos ◽  
R. C. Sartore ◽  
B. L. Ramalho ◽  
E. S. Costa ◽  
S. K. Rehen
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Cycle Arrest

Microcephaly and Effects of Cdk5rap2 Downregulation in Murine Embryonic Stem Cells

2012 ◽  
Vol 43 (02) ◽  
Author(s):  
N Krämer ◽  
L Issa ◽  
G Neubert ◽  
A Seiler ◽  
O Ninnemann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression
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