Purpose: This study was intended to observe electroencephalographic (EEG) changes and
convulsion attacks in children receiving neural precursor cell transplantation, and to explore the possibility
of electrophysiological changes and risk of convulsion occurrence after cell transplantation.
Method:
228 children were included in this study who received neural precursor cell transplantation
in our hospital between March 2008 and July 2012. No history of convulsion attacks was elicited before
cell transplantation. Data about EEG change and convulsion occurrence before and after cell
transplantation were analyzed statistically.
Results:
Of the 228 pediatric patients, EEG improvement, deterioration and no significant change
were observed in 60, 45 and 122 patients, respectively. One month after transplantation, four (1.76%)
patients experienced new convulsions. Of the 227 patients, 25 showed increased and/or abnormal discharges
on EEG. Of these, 19 underwent EEG re-examination six months post-operation. Except the
convulsive cases mentioned above, there were no new cases of convulsions in the remaining patients.
Of the 27 patients including those with abnormal discharge, increased discharge and convulsion attacks,
17 achieved varying degrees of therapeutic efficacy.
Conclusion:
Intraventricular transplantation of neural precursor cells is associated with EEG changes
in some children and clinical convulsion attacks in individual patients. However, these abnormal
changes do not last long and usually return to normal levels within 1-6 months after surgery, along
with disappearance of convulsions. Simultaneous occurrence of EEG changes and convulsions do not
appear to affect therapeutic efficacy.
Selenium effectively inhibits ROS-mediated apoptotic neural precursor cell death in vitro and in vivo in traumatic brain injury
