OP31.02: Changes in endometriomas and rectovaginal endometriotic nodules during treatment with norethindrone acetate or extended-cycle oral contraceptive

Extended-cycle combined hormonal contraception has become a common practice among women seeking effective contraception and menstrual regulation. Extended cycle regimens have the benefit of decreasing scheduled bleeding as compared to traditional combined oral contraceptive (COC) regimens containing 21 days of hormones followed by a 7-day hormone-free interval (HFI) by reducing the frequency of the HFI. The newest FDA approved product in this family of contraceptive regimens is a 91-day COC regimen containing 0.02 mg ethinyl estradiol (EE) and 0.1 mg levonorgestrel (LNG) for 84 days followed by a 7-day interval with 0.01 mg EE. This regimen has been evaluated in one pivotal trial and demonstrated to have efficacy and a side effect profile similar to the other currently available FDA approved 91-day extended-cycle regimens. This is the first 91-day regimen formulated with 0.02 mg EE and offers women an effective option for contraception and menstrual cycle control.

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The lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: a review of the literature on ethinyl estradiol 20 µg/levonorgestrel 100 µg + ethinyl estradiol 10 µg

International Journal of Women s Health ◽

10.2147/ijwh.s6437 ◽

2010 ◽

pp. 235

Author(s):

Jessica Kiley

Keyword(s):

United States ◽

Oral Contraceptive ◽

Ethinyl Estradiol ◽

Oral Contraceptive Pill ◽

The United States ◽

Review Of The Literature ◽

Contraceptive Pill ◽

Combined Oral Contraceptive ◽

Extended Cycle

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Colorimetric Determination of the Progestational Steroids in Contraceptive Tablets

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/53.4.831 ◽

1970 ◽

Vol 53 (4) ◽

pp. 831-833

Author(s):

John Y P Wu

Keyword(s):

Oral Contraceptive ◽

Medroxyprogesterone Acetate ◽

Collaborative Study ◽

Chloroform Extract ◽

Colorimetric Determination ◽

Standard Deviations ◽

Isonicotinyl Hydrazide ◽

Norethindrone Acetate

Abstract Norethindrone, norethindrone acetate, dimethisterone, medroxyprogesterone acetate, and norethynodrel are determined in oral contraceptive tablets. For the first 4 compounds, a chloroform extract of the tablets is treated directly with isonicotinyl hydrazide reagent to produce a stable color which is measured at 380 nm. The chloroform extract of norethynodrel tablets is isomerized before the reagent is added. An intralaboratory study gave good results, with standard deviations of 0.74 to 1.21%. A collaborative study is recommended.

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Effect of extended-cycle regimen with an oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest on bleeding patterns, safety, acceptance and contraceptive efficacy

Contraception ◽

10.1016/j.contraception.2011.01.002 ◽

2011 ◽

Vol 84 (2) ◽

pp. 133-143 ◽

Cited By ~ 17

Author(s):

Inka Wiegratz ◽

Skadi Stahlberg ◽

Torsten Manthey ◽

Nicole Sänger ◽

Katrin Mittmann ◽

...

Keyword(s):

Oral Contraceptive ◽

Contraceptive Efficacy ◽

Extended Cycle

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Extended-Cycle Oral Contraceptive Pills with 10 μG Ethinyl Estradiol Pills in Place of Placebo Pills

Women s Health ◽

10.2217/17455057.3.5.529 ◽

2007 ◽

Vol 3 (5) ◽

pp. 529-535 ◽

Cited By ~ 2

Author(s):

Anita L Nelson

Keyword(s):

Oral Contraceptive ◽

Birth Control ◽

Low Dose ◽

Ethinyl Estradiol ◽

Oral Contraceptive Pills ◽

Contraceptive Pills ◽

Unscheduled Bleeding ◽

Birth Control Pills ◽

Extended Cycle ◽

Stimulation Of

The elimination of monthly withdrawal bleeding with use of extended-cycle (84 pills) monophasic birth-control pills has modernized oral contraceptives. The use of ethinyl estradiol 10 μg pills in place of the seven placebo pills addresses the problems posed by 21/7 formulations of low-dose birth-control pills, which allow early stimulation of ovarian follicles, and of the early 84/7 formulations, which had higher rates of unscheduled bleeding and spotting.

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