scholarly journals VP31.13: SARS‐CoV‐2‐positive placenta shows intervillous space collapse and perivillous fibrinoid deposition

2021 ◽  
Vol 58 (S1) ◽  
pp. 229-229
Author(s):  
P. Garcia‐Canadilla ◽  
A. Nadal ◽  
A. Bonnin ◽  
F. Crovetto ◽  
M. Lopez ◽  
...  
Keyword(s):  
Intervillous Space

Distribution of Bupivacaine Enantiomers and Lidocaine and Its Metabolite in the Placental Intervillous Space and in the Different Maternal and Fetal Compartments in Term Pregnant Women

2011 ◽  
Vol 51 (2) ◽  
pp. 212-217 ◽  
Author(s):  
Luciana de Barros Duarte ◽  
Elaine Cristine Dantas Móises ◽  
Ricardo Carvalho Cavalli ◽  
Vera Lucia Lanchote ◽  
Geraldo Duarte ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Intervillous Space

Syncytiotrophoblastic vesicles in placental intervillous space

2006 ◽  
Vol 195 (1) ◽  
pp. 304-307 ◽  
Author(s):  
Toshio Fujikura ◽  
Makio Mukai
Keyword(s):  
Intervillous Space

scholarly journals Features of the histological structure of the placenta in women with recurrent miscarriage depending on polymorphic variants of the metalloproteinase and hemostasis systems

2020 ◽  
Vol 17 (2) ◽  
pp. 158-169
Author(s):  
T. N. Grinevich ◽  
S. A. Lyalikov ◽  
V. A. Basinsky ◽  
T. T. Shtabinskaya ◽  
C. M. Butolina ◽  
...  
Keyword(s):  
Comparison Group ◽  
Recurrent Miscarriage ◽  
Morphological Characteristics ◽  
Reproductive Function ◽  
Placental Tissue ◽  
Histological Structure ◽  
Chorionic Villi ◽  
Intervillous Space ◽  
Reproductive Losses ◽  
Polymorphic Variants

The article is devoted to the analysis of the morphological characteristics of placental tissue in women with early reproductive losses with recurrent miscarriage, depending on the presence of polymorphic variants of metalloproteinases and hemostasis. It was established that in women with recurrent miscarriage, the area of the trophoblast of the placenta is significantly larger (р < 0.003), the area of the chorionic villi is smaller (р < 0.04) than in the group of women with implemented reproductive function. Thrombosis of the chorionic vessels, necrosis and calcinates in the placenta with PNF were detected in 80.0 % (р = 0.001), 93.3 % (р = 0.001), and 30.0 % (р = 0.049) of cases, respectively, which is significantly higher than in the comparison group. In patients with PNP with the T/T genotype of the 735 C/T polymorphism of the MMP-2 gene, the trophoblast area is significant (р < 0.05) more than with the C/C genotype, acute full-back (р = 0.02) and intervillous hemorrhage (р = 0.02). In women with the C/T genotype of the polymorphism 735 C/T of the MMP-2 gene, edema and dystrophic changes in the chorionic villi, placental necrosis are determined more often (р = 0.02) than with the C/C genotype. In carriers of the T allele of the polymorphism 735 C/T of the MMP-2 gene in the placenta, necrosis is significantly more common than in the CC genotype; the carriage of the T allele is also associated with large values of the relative area of the trophoblast and the stromal-intervillous relation, as well as with a smaller value of the ratio of the intervillous space area to the total area of the photograph.

Circulation in the intervillous space of the primate placenta

1962 ◽  
Vol 84 (11) ◽  
pp. 1649-1663 ◽  
Author(s):  
Elizabeth M. Ramsey
Keyword(s):  
Intervillous Space

Intervillous Space: Infiltrates

2018 ◽  
pp. 213-219
Author(s):  
Adrian K. Charles ◽  
Marie-Anne Bründler
Keyword(s):  
Intervillous Space

scholarly journals An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer

Glycobiology ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 989-1002 ◽  
Author(s):  
Alejandro Gómez Toledo ◽  
Jessica Pihl ◽  
Charlotte B Spliid ◽  
Andrea Persson ◽  
Jonas Nilsson ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Affinity Purification ◽  
Chondroitin Sulfate Proteoglycans ◽  
Intervillous Space ◽  
Core Proteins ◽  
Heterogenous Group ◽  
Tumor Tissues ◽  
Infected Cells ◽  
Cancer Tissues

Abstract Chondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein, expressed at the surface of infected erythrocytes during Plasmodium falciparum infection. Infected cells adhere to syncytiotrophoblasts or get trapped within the intervillous space by binding to a determinant in a 4-O-sulfated CS chains. However, the exact structure of these glycan sequences remains unclear. VAR2CSA-reactive CS is also expressed by tumor cells, making it an attractive target for cancer diagnosis and therapeutics. The identities of the proteoglycans carrying these modifications in placental and cancer tissues remain poorly characterized. This information is clinically relevant since presentation of the glycan chains may be mediated by novel core proteins or by a limited subset of established proteoglycans. To address this question, VAR2CSA-binding proteoglycans were affinity-purified from the human placenta, tumor tissues and cancer cells and analyzed through a specialized glycoproteomics workflow. We show that VAR2CSA-reactive CS chains associate with a heterogenous group of proteoglycans, including novel core proteins. Additionally, this work demonstrates how affinity purification in combination with glycoproteomics analysis can facilitate the characterization of CSPGs with distinct CS epitopes. A similar workflow can be applied to investigate the interaction of CSPGs with other CS binding lectins as well.

The distribution of microvilli over the villous surface of the normal human term placenta is homogenous

1995 ◽  
Vol 7 (5) ◽  
pp. 1269 ◽  
Author(s):  
AL Karimu ◽  
GJ Burton
Keyword(s):  
Regional Differences ◽  
Amplification Factor ◽  
Ultrastructural Examination ◽  
Human Term Placenta ◽  
Term Placenta ◽  
Intervillous Space ◽  
Normal Term ◽  
Significant Difference ◽  
Villous Surface ◽  
Normal Human

The study was carried out to estimate stereologically whether regional differences exist in the distribution of microvilli between vasculo-syncytial (VSM) and non-vasculo-syncytial (non-VSM) areas of the villous surface in normal term placenta. In ten placentae a normal lobe was perfusion-fixed at a pressure of 60 mm Hg, and the intervillous space was perfused at 10 mm Hg. The tissue was routinely processed for ultrastructural examination. Stereological estimates relating to the length and diameter of microvilli, and to the villous surface amplification factor in adjacent but contrasting (VSM and non-VSM) regions, were obtained. A paired 't' test showed no significant difference in the villous surface amplification factor between the two regions (5.18 +/- 0.54 and 5.22 +/- 0.54 respectively, mean +/- s.e.m. P > 0.05). In addition, there were no significant differences between the length and diameter of microvilli in both regions (P > 0.05 in both). The results confirm that the normal term placenta has a continuous and even covering of microvilli over the syncytium.

Pressures in the human amniotic fluid and intervillous space

1957 ◽  
Vol 74 (5) ◽  
pp. 1018-1021 ◽  
Author(s):  
Louis M. Hellman ◽  
Vincent Tricomi ◽  
Om Gupta
Keyword(s):  
Amniotic Fluid ◽  
Human Amniotic Fluid ◽  
Intervillous Space

Co-Occurrence of Massive Perivillous Fibrin Deposition and Chronic Intervillositis: Case Report

2006 ◽  
Vol 9 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Martin A. Weber ◽  
Peter G.J. Nikkels ◽  
Karen Hamoen ◽  
Johannes J. Duvekot ◽  
Ronald r. de Krijger
Keyword(s):  
Case Report ◽  
High Risk ◽  
Fetal Death ◽  
Fetal Outcome ◽  
Intrauterine Fetal Death ◽  
Histological Findings ◽  
Fibrin Deposition ◽  
Intervillous Space ◽  
Intrauterine Fetal Growth Restriction ◽  
First Time

Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in the same placenta, resulting in severe intrauterine fetal growth restriction and intrauterine fetal death at 37 weeks of gestation. Characteristic histological findings included both very extensive perivillous deposition of fibrinoid material and a heavy infiltrate of CD68-positive macrophages/monocytes in the maternal intervillous space. To our knowledge, this is the first time the co-occurrence of MFD and CI is reported in the literature.

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