scholarly journals Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor

2010 ◽  
Vol 36 (2) ◽  
pp. 249-251 ◽  
Author(s):  
M. Okumura ◽  
K. Fushida ◽  
W. W. Rezende ◽  
R. Schultz ◽  
M. ZUGAIB
Keyword(s):  
Gestational Trophoblastic Disease ◽  
Sonographic Appearance ◽  
Trophoblastic Disease ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor

Epithelioid trophoblastic tumor: a case report

2006 ◽  
Vol 16 (3) ◽  
pp. 1473-1476 ◽  
Author(s):  
C. Lo ◽  
I. Low ◽  
A. L. Tan ◽  
J. Baranyai
Keyword(s):  
Gestational Trophoblastic Disease ◽  
Human Chorionic Gonadotrophin ◽  
Trophoblastic Disease ◽  
Trophoblastic Tumor ◽  
Uncomplicated Pregnancy ◽  
Epithelioid Trophoblastic Tumor ◽  
Trophoblastic Tumors ◽  
Clinicopathologic Findings ◽  
Tumor Like Lesions ◽  
Distinguishing Features

Epithelioid trophoblastic tumor is a rare and distinctive pathologic entity within the complex family of gestational trophoblastic disease. We describe a case of epithelioid trophoblastic tumor occurring in a 34-year-old woman, who presented with a large uterine tumor 3 years following an uncomplicated pregnancy. The clinicopathologic findings in this case are typical of this unusual entity and consistent with current literature, with the exception of negative beta-human chorionic gonadotrophin levels. The distinguishing features from other intermediate trophoblastic tumors and tumor-like lesions are discussed.

Epithelioid Trophoblastic Tumor: Review of a Rare Neoplasm of the Chorionic-Type Intermediate Trophoblast

2006 ◽  
Vol 130 (12) ◽  
pp. 1875-1877
Author(s):  
Kimberly H. Allison ◽  
Jason E. Love ◽  
Rochelle L. Garcia
Keyword(s):  
Gestational Trophoblastic Disease ◽  
Reproductive Age ◽  
Placental Lactogen ◽  
Variable Expression ◽  
Trophoblastic Tumor ◽  
Trophoblastic Cells ◽  
Epithelioid Trophoblastic Tumor ◽  
Positive Immunostaining ◽  
Nodular Growth ◽  
Type Intermediate

Abstract We present a brief review of epithelioid trophoblastic tumor, a rare trophoblastic neoplasm derived from chorionic-type intermediate trophoblastic cells that typically presents in reproductive-age women between 1 and 18 years following a previous gestation. Histologic features include a nodular growth pattern of monomorphic, epithelioid cells within a hyaline matrix. Areas of necrosis and mitotic activity (0–9 mitoses per 10 high-power fields) are additional features of this neoplasm. Positive immunostaining for p63 and cytokeratin, frequent location in the lower uterine segment and endocervix, as well as the epithelioid appearance can lead to confusion with squamous cell carcinoma. Inhibin-α is typically expressed, as well as focal, more variable expression of other trophoblastic markers including β-human chorionic gonadotropin, human placental lactogen, placental alkaline phosphate, and Mel-CAM (CD148). The clinical behavior of this rare form of gestational trophoblastic disease is difficult to predict. Although most cases follow a benign course following resection, there is a potential for metastatic disease.

Epithelioid trophoblastic tumor (ETT) initially interpreted as cervical cancer

2003 ◽  
Vol 13 (4) ◽  
pp. 551-554 ◽  
Author(s):  
F. Narita ◽  
K. Takeuchi ◽  
S. Hamana ◽  
C. Ohbayashi ◽  
M. Ayata ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Wide Spectrum ◽  
Punch Biopsy ◽  
Rare Form ◽  
Clinical Behavior ◽  
Small Tumor ◽  
Trophoblastic Disease ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor ◽  
Spontaneous Delivery

The epithelioid trophoblastic tumor (ETT) is a rare form of trophoblastic disease and shows a wide spectrum of differential diagnoses and clinical behavior. A 53-year-old woman presented with ETT presumably originated in spontaneous delivery of 25 years ago and was initially diagnosed as cervical cancer on cervical punch biopsy followed by radical hysterectomy. The uterus showed a small tumor restricted to the cavum with no cervical infiltration, resembling ETT in histologic and immunohistochemical features. The difficulties and clues in distinguishing ETT from nontrophoblastic lesions are discussed.

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

2015 ◽  
Vol 137 (3) ◽  
pp. 456-461 ◽  
Author(s):  
M.R. Davis ◽  
B.E. Howitt ◽  
B.J. Quade ◽  
C.P. Crum ◽  
N.S. Horowitz ◽  
...  
Keyword(s):  
New England ◽  
Case Series ◽  
Single Institution ◽  
Trophoblastic Disease ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor

scholarly journals Fertility and pregnancy outcome in gestational trophoblastic disease

2021 ◽  
Vol 31 (3) ◽  
pp. 399-411
Author(s):  
Ulrika Joneborg ◽  
Leonoor Coopmans ◽  
Nienke van Trommel ◽  
Michael Seckl ◽  
Christianne A R Lok
Keyword(s):  
Pregnancy Outcome ◽  
Single Agent ◽  
Gestational Trophoblastic Disease ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Gestational Trophoblastic Neoplasia ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor ◽  
Placental Site ◽  
Multi Agent

The aim of this review is to provide an overview of existing literature and current knowledge on fertility rates and reproductive outcomes after gestational trophoblastic disease. A systematic literature search was performed to retrieve all available studies on fertility rates and reproductive outcomes after hydatidiform mole pregnancy, low-risk gestational trophoblastic neoplasia, high- and ultra-high-risk gestational trophoblastic neoplasia, and the rare placental site trophoblastic tumor and epithelioid trophoblastic tumor forms of gestational trophoblastic neoplasia. The effects of single-agent chemotherapy, multi-agent including high-dose chemotherapy, and immunotherapy on fertility, pregnancy wish, and pregnancy outcomes were evaluated and summarized. After treatment for gestational trophoblastic neoplasia, most, but not all, women want to achieve another pregnancy. Age and extent of therapy determine if there is a risk of loss of fertility. Single-agent treatment does not affect fertility and subsequent pregnancy outcome. Miscarriage occurs more often in women who conceive within 6 months of follow-up after chemotherapy. Multi-agent chemotherapy hastens the natural menopause by three years and commonly induces a temporary amenorrhea, but in young women rarely causes permanent ovarian failure or infertility. Subsequent pregnancies have a high chance of ending with live healthy babies. In contrast, high-dose chemotherapy typically induces permanent amenorrhea, and no pregnancies have been reported after high-dose chemotherapy for gestational trophoblastic neoplasia. Immunotherapy is promising and may give better outcomes than multiple schedules of chemotherapy or even high-dose chemotherapy. The first pregnancy after immunotherapy has recently been described. Data on fertility-sparing treatment in placental site trophoblastic tumor and epithelioid trophoblastic tumor are still scarce, and this option should be offered with caution. In general, patients with gestational trophoblastic neoplasia may be reassured about their future fertility and pregnancy outcome. Detailed registration of high-risk gestational trophoblastic neoplasia is still indispensable to obtain more complete data to better inform patients in the future.

scholarly journals P21.09: Sonographic appearance of epithelioid trophoblastic tumor

2009 ◽  
Vol 34 (S1) ◽  
pp. 262-262
Author(s):  
M. Okumura ◽  
K. Fushida ◽  
W. W. Rezende ◽  
M. Zugaib
Keyword(s):  
Sonographic Appearance ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor
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