OC17.05: Cervical gland area as an ultrasonographic marker for predicting preterm delivery in high risk pregnant women

Background: The World Health Organization (WHO) factsheet revealed that 15 million babies are born too early every year and almost 1 million children die each year due to complications of preterm birth. The objective of this study was to determine whether cervicovaginal β-hCG level can be used as predictor of preterm delivery in asymptomatic high-risk pregnant women at 24-34 weeks gestation age.Methods: This was prospective observational study. Total 134 asymptomatic pregnant women were taken for study who had at least one risk factor for preterm delivery at 24-34 weeks gestation age. Cervicovaginal secretion was collected and β-hCG level was measured by chemiluminescent immunoassay.Results: Out of 134 cases, 42.5% had preterm delivery and 57.5% had term delivery. Mean cervicovaginal β-hCG level (mIU/ml) in preterm delivery group was 39.38±19.66 and term delivery group was 21.86±11.18. Cervicovaginal β-hCG level was significantly higher in preterm group compare to term group demonstrating significant association of raised β-hCG with preterm group (p value <0.001). ROC curve analysis was done to find out best cut off value of cervicovaginal β-hCG for prediction of preterm delivery and optimal cut off value was 36.45 mIU/ml. The optimal cut off value for cervicovaginal β-hCG (36.45 mIU/ml) gave sensitivity 71.9%, specificity 81.8%, positive predictive value 74.5%, negative predictive value 79.7% and diagnostic accuracy of 77.6% for prediction of preterm delivery.Conclusions: Cervicovaginal β-hCG can be used as sensitive and specific biomarker of prediction of preterm delivery in asymptomatic high-risk women.

Download Full-text

Cervical gland area as an ultrasonographic marker for preterm delivery

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70073-0 ◽

2007 ◽

Vol 2007 ◽

pp. 101-103

Author(s):

J.S. Dungan

Keyword(s):

Preterm Delivery ◽

Gland Area ◽

Cervical Gland

Download Full-text

Significance of Cervical Gland Area in Predicting Preterm Birth for Patients with Threatened Preterm Delivery: Comparison with Cervical Length and Fetal Fibronectin

Gynecologic and Obstetric Investigation ◽

10.1159/000209394 ◽

2009 ◽

Vol 68 (1) ◽

pp. 1-8 ◽

Cited By ~ 15

Author(s):

Hirobumi Asakura ◽

Takehiko Fukami ◽

Ryuhei Kurashina ◽

Naoko Tateyama ◽

Daisuke Doi ◽

...

Keyword(s):

Preterm Birth ◽

Preterm Delivery ◽

Cervical Length ◽

Fetal Fibronectin ◽

Gland Area ◽

Cervical Gland

Download Full-text

Obstetric Complications and Pregnancy Outcomes in Patients with Endometriosis

Doctor Ru ◽

10.31550/1727-2378-2021-20-6-33-45 ◽

2021 ◽

Vol 20 (6) ◽

pp. 33-45

Author(s):

A.V. Borisova ◽

◽

S.R.D. Konnon ◽

A.I. Plotnikova ◽

O.N. Khallyeva ◽

...

Keyword(s):

High Risk ◽

Pregnant Women ◽

Preterm Delivery ◽

Obstetric Complications ◽

Favourable Effect ◽

Keywords Endometriosis ◽

Key Points ◽

Spontaneous Hemoperitoneum ◽

Endometrium Receptivity ◽

The Impact

Objective of the Review: To study the impact of endometriosis on the course and outcomes of pregnancy; to propose methods for prevention of obstetrics complications in pregnant women with endometriosis. Key Points. Pregnant women with endometriosis are at a high risk of miscarriage, preterm delivery, preeclampsia, placental disorders, intranatal and postnatal bleeding, still birth, high rates of caesarean section; and at a risk of acute complications from endometriosis, e.g., spontaneous hemoperitoneum. Endometriosis is associated with progesterone resistivity, impaired endometrium receptivity; therefore, prescription of progesterone to pregnant women with endometriosis can be a key to prevention of not only miscarriages and preterm delivery, but also of preeclampsia and placental disorders. Folic acid has favourable effect for placenta formation. Low doses (75–150 mg/day) of acetylsalicylic acid prevent placentation disorders. Conclusion. In order to prevent impaired implantation, placentation, cytotrophoblastic invasion, and uteroplacental perfusion with a high risk of obstetric complications, pregnant women with endometriosis should take progesterone, folic and acetylsalicylic acids. Keywords: endometriosis, obstetric complications, pregnancy follow-up

Download Full-text

Pre-Exposure Prophylaxis for COVID-19 in Pregnant Women.

10.31219/osf.io/p9w6c ◽

2021 ◽

Author(s):

Melissa Fesler ◽

Raphael B. Stricker

Keyword(s):

Respiratory Failure ◽

High Risk ◽

Pregnant Women ◽

Preterm Delivery ◽

Severe Illness ◽

High Risk Population ◽

Safety Testing ◽

Vaccine Trials ◽

Exposure Prophylaxis ◽

In Pregnancy

Pregnant women are at higher risk for developing severe complications of COVID-19 including preterm delivery, respiratory failure and death. Although vaccines to prevent COVID-19 are being developed, pregnant women are not included in the current COVID-19 vaccine trials and initially this population may not be eligible for COVID-19 vaccines due to lack of safety testing in pregnancy. As an alternate approach, we discuss the concept of pre-exposure prophylaxis (PrEP) using medications that are approved for use in pregnant women to prevent gestational problems and severe illness in this high-risk population. In particular, the use of hydroxychloroquine PrEP affords a safe and readily available means to avoid COVID-19 complications in pregnancy.

Download Full-text