In vitro dissolution considerations associated with nano drug delivery systems

Background:Nanotech products are gaining more attention depending on their advantages for improving drug solubility, maintenance of drug targeting, and attenuation of drug toxicity. In vitro release test is the critical physical parameter to determine the pharmaceutical quality of the product, to monitor formulation design and batch-to-batch variation.Methods:Spectrophotometric and chromatographic methods are mostly used in quantification studies from in vitro release test of nano-drug delivery systems. These techniques have advantages and disadvantages with respect to each other considering dynamic range, selectivity, automation, compatibility with in vitro release media and cost per sample.Results:It is very important to determine the correct kinetic profile of active pharmaceutical substances. At this point, the analytical method used for in vitro release tests has become a very critical parameter to correctly assess the profiles. In this review, we provided an overview of analytical methods applied to the in vitro release assay of various nanopharmaceuticals.Conclusion:This review presents practical direction on analytical method selection for in vitro release test on nanopharmaceuticals. Moreover, precautions on analytical method selection, optimization and validation were discussed.

Download Full-text

Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Improving In Vitro Dissolution and Oral Absorption of Pueraria Lobata Isoflavone

Drug Development and Industrial Pharmacy ◽

10.1081/ddc-200054309 ◽

2005 ◽

Vol 31 (4) ◽

pp. 349-356

Author(s):

Shengmiao Cui ◽

Chunshun Zhao ◽

Dawei Chen ◽

Zhonggui He

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Absorption ◽

Delivery Systems ◽

In Vitro Dissolution ◽

Pueraria Lobata

Download Full-text

Development of an in vitro dissolution method using microdialysis sampling technique for implantable drug delivery systems

Journal of Pharmaceutical Sciences ◽

10.1021/js980480g ◽

1999 ◽

Vol 88 (10) ◽

pp. 1036-1040 ◽

Cited By ~ 17

Author(s):

Alekha K. Dash ◽

Paul W. Haney ◽

Marc J. Garavalia

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Sampling Technique ◽

Delivery Systems ◽

In Vitro Dissolution ◽

Microdialysis Sampling ◽

Dissolution Method ◽

Implantable Drug Delivery Systems

Download Full-text

Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Materials ◽

10.3390/ma13020329 ◽

2020 ◽

Vol 13 (2) ◽

pp. 329 ◽

Cited By ~ 7

Author(s):

Daria Lovskaya ◽

Natalia Menshutina

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Amorphous State ◽

Supercritical Drying ◽

Delivery Systems ◽

In Vitro Dissolution ◽

Supercritical Adsorption ◽

The Stability ◽

Active Substances

The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

Download Full-text