scholarly journals Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 329 ◽  
Author(s):  
Daria Lovskaya ◽  
Natalia Menshutina
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Amorphous State ◽  
Supercritical Drying ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Supercritical Adsorption ◽  
The Stability ◽  
Active Substances

The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

scholarly journals Dissolution improvement of solid self-emulsifying drug delivery systems of fenofi brate using an inorganic high surface adsorption material

2015 ◽  
Vol 65 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Gamal Shazly ◽  
Kazi Mohsin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
High Surface ◽  
Amorphous State ◽  
Delivery Systems ◽  
Classification Systems ◽  
In Vitro Dissolution ◽  
Dissolution Studies

Abstract Solidification of lipid formulations using adsorbents is a recent technique attracting great interest due to its favourable properties including flexibility in dose division, reduction of intra-subject and inter-subject variability, improvement in efficacy/safety profile and enhancement of physical/ chemical stability. The current study aims to convert liquid self-emulsifying/nanoemulsifying drug delivery systems (SEDDS/SNEDDS) into solid SEDDS/SNEDDS and to assess how adsorption of the drug onto an inorganic high surface area material, NeusilinR grade US2 (NUS2), affects its in vitro dissolution performance. Lipid formulation classification systems (LFCS) Type III formulations were designed for the model anti-cholesterol drug fenofibrate. NUS2 was used to solidify the SEDDS/SNEDDS. Particle size and SEM analyses of solid SEDDS/SNEDDS powder were carried out to investigate the adsorption efficiency. In vitro dissolution studies were conducted to compare the developed formulations with the marketed product. The results of characterization studies showed that the use of 50 % (m/m) adsorbent resulted in superior flowability and kept the drug stable is amorphous state. Dissolution studies allow the conclusion that the formulation containing a surfactant of higher water solubility (particularly, Type IIIB SNEDDS) has comparably faster and higher release profiles than Type IIIA (SEDDS) and marketed product

scholarly journals An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

2020 ◽  
Vol 149 ◽  
pp. 21-29 ◽  
Author(s):  
Caroline Alvebratt ◽  
Janneke Keemink ◽  
Khadijah Edueng ◽  
Ocean Cheung ◽  
Maria Strømme ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution

Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases

2019 ◽  
Vol 25 (14) ◽  
pp. 1604-1615 ◽  
Author(s):  
Brenna L.C. Gondim ◽  
João A. Oshiro-Júnior ◽  
Felipe H.A. Fernanandes ◽  
Fernanda P. Nóbrega ◽  
Lúcio R.C. Castellano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plant Extracts ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Delivery Systems ◽  
Active Components ◽  
Current Therapies ◽  
The Stability

Background: Plant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages, plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds; enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities.

An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

2018 ◽  
Vol 147 ◽  
pp. 350-366 ◽  
Author(s):  
Mario Jug ◽  
Anita Hafner ◽  
Jasmina Lovrić ◽  
Maja Lusina Kregar ◽  
Ivan Pepić ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Mucosal Drug Delivery

Role of polymer/polymer and polymer/drug specific interactions in drug delivery systems

2019 ◽  
Vol 39 (6) ◽  
pp. 534-544
Author(s):  
Farid Ouazib ◽  
Naima Bouslah Mokhnachi ◽  
Nabila Haddadine ◽  
Regis Barille
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymer System ◽  
Amorphous State ◽  
Delivery Systems ◽  
Release Mechanism ◽  
Release Kinetic ◽  
X Ray Diffraction ◽  
Scanning Calorimetry

Abstract Drug delivery systems based upon the blending of Arabic gum and poly(N-vinylpyrrolidone) (AG/PVP) were prepared for the controlled release of acebutolol (Acb) hydrochloride. The prepared blends containing Acb were characterized using different techniques. The presence of physical interactions between the drug and polymer matrices was observed with Fourier-transform infrared spectroscopy. These interactions resulted in the transition of the drug from a crystalline to an amorphous state into the polymeric matrices, as demonstrated by differential scanning calorimetry and X-ray diffraction analysis. The thermogravimetric analysis study confirmed the presence of these interactions, which had a stabilizing effect on the drug against both thermal degradation and crystallinity. The in vitro release of Acb from the AG/PVP polymer system was investigated. Each drug-loaded system was used in a tablet formulation. Moreover, an in vitro dissolution study was carried out in three different dissolution media, and comparison of the dissolution profiles of the different dosage forms revealed that the polymer blend matrix had a better release-retarding efficiency. To better understand the release mechanism, the dissolution data were fitted to various release kinetic models.

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