Nitric Oxide Relaxes Rabbit Corpus Cavernosum Smooth Muscle via a Potassium-Conductive Pathway

1996 ◽  
Vol 219 (2) ◽  
pp. 382-387 ◽  
Author(s):  
Allen D. Seftel ◽  
Krista A. Viola ◽  
Scott E. Kasner ◽  
Michael B. Ganz
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Corpus Cavernosum ◽  
Conductive Pathway ◽  
Rabbit Corpus Cavernosum

scholarly journals Synthesis and Modeling Studies of Furoxan Coupled Spiro-Isoquinolino Piperidine Derivatives as NO Releasing PDE 5 Inhibitors

Biomedicines ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 121
Author(s):  
Swami Prabhuling ◽  
Yasinalli Tamboli ◽  
Prafulla B. Choudhari ◽  
Manish S. Bhatia ◽  
Tapan Kumar Mohanta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Soluble Guanylate Cyclase ◽  
Corpus Cavernosum ◽  
Active Role ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Muscle Relaxant Activity

Nitric oxide (NO) is considered to be one of the most important intracellular messengers that play an active role as neurotransmitter in regulation of various cardiovascular physiological and pathological processes. Nitric oxide (NO) is a major factor in penile erectile function. NO exerts a relaxing action on corpus cavernosum and penile arteries by activating smooth muscle soluble guanylate cyclase and increasing the intracellular concentration of cyclic guanosine monophosphate (cGMP). Phophodiesterase (PDE) inhibitors have potential therapeutic applications. NO hybridization has been found to improve and extend the pharmacological properties of the parental compound. The present study describes the synthesis of novel furoxan coupled spiro-isoquinolino-piperidine derivatives and their smooth muscle relaxant activity. The study reveals that, particularly 10d (1.50 ± 0.6) and 10g (1.65 ± 0.7) are moderate PDE 5 inhibitors as compared to Sidenafil (1.43 ± 0.5). The observed effect was explained by molecular modelling studies on phosphodiesterase.

Modulation of Intrinsic Cavernous Tone and Nitric Oxide Production by Arginase in Rabbit Corpus Cavernosum

2004 ◽  
Vol 171 (1) ◽  
pp. 490-494 ◽  
Author(s):  
HITOSHI MASUDA ◽  
MASATAKA YANO ◽  
YASUYUKI SAKAI ◽  
KAZUNORI KIHARA ◽  
YUKINAO YAMAUCHI ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Corpus Cavernosum ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Rabbit Corpus Cavernosum

Enhanced Contractility of Rabbit Corpus Cavernosum Smooth Muscle by Oxidized Low Density Lipoproteins

1999 ◽  
Vol 162 (2) ◽  
pp. 629-630
Author(s):  
T.Y. Ahn ◽  
D. Gomez-Coronado ◽  
V. Martinez ◽  
P. Cuevas ◽  
I. Goldstein ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Corpus Cavernosum ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins ◽  
Rabbit Corpus Cavernosum

Modulation of Ca 2+ Sensitivity Regulates Contractility of Rabbit Corpus Cavernosum Smooth Muscle

2003 ◽  
Vol 169 (6) ◽  
pp. 2412-2416 ◽  
Author(s):  
RYOSUKE TAKAHASHI ◽  
JUNJI NISHIMURA ◽  
KATSUYA HIRANO ◽  
SEIJI NAITO ◽  
HIDEO KANAIDE
Keyword(s):  
Smooth Muscle ◽  
Corpus Cavernosum ◽  
Rabbit Corpus Cavernosum
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