Neuronal Differentiation of PC12 Cells Involves Changes in Protein Kinase C-θ Distribution and Molecular Properties

2000 ◽  
Vol 275 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Bianca Sparatore ◽  
Mauro Patrone ◽  
Mario Passalacqua ◽  
Marco Pedrazzi ◽  
Sandro Pontremoli ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Molecular Properties ◽  
Kinase C

Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells

1990 ◽  
Vol 10 (6) ◽  
pp. 2983-2990
Author(s):  
J C Lacal ◽  
A Cuadrado ◽  
J E Jones ◽  
R Trotta ◽  
D E Burstein ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Neuronal Differentiation ◽  
Phorbol Esters ◽  
Ras Oncogene ◽  
Intact Cells ◽  
Pc 12 Cells ◽  
Kinase C ◽  
Ras P21

Expression of the N-ras oncogene under the control of the glucocorticoid-responsive promoter in the pheochromocytoma cell line UR61, a subline of PC-12 cells, has been used to investigate the differentiation process to neuronal cells triggered by ras oncogenes (I. Guerrero, A. Pellicer, and D. E. Burstein, Biochem. Biophys. Res. Commun. 150:1185-1192, 1988). Using ras-inducible cell lines, we observed that expression of the oncogenic N-ras p21 protein interferes with the ability of phorbol esters to induce downregulation of protein kinase C. This effect was associated with the appearance of immunologically detectable protein kinase C as well as the activity of the enzyme as analyzed either by binding of [3H]phorbol-12,13-dibutyrate in intact cells or by in vitro kinase activity. These results indicate a relationship between ras p21 and protein kinase C in neuronal differentiation in this model system. Comparison to the murine fibroblast system suggests that this relationship may be functional.

A possible role for protein kinase C in CO2/H+-induced c-fos mRNA expression in PC12 cells

1998 ◽  
Vol 111 (2) ◽  
pp. 127-135 ◽  
Author(s):  
N.T Kuo ◽  
F.H Agani ◽  
M.A Haxhiu ◽  
C.H Chang
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Pc12 Cells ◽  
Kinase C

Nerve growth factor enhances the level of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells

1986 ◽  
Vol 139 (2) ◽  
pp. 644-651 ◽  
Author(s):  
C.O.M. Van Hooff ◽  
P.N.E. De Graan ◽  
J. Boonstra ◽  
A.B. Oestreicher ◽  
M.H. Schmidt-Michels ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Kinase C ◽  
Pheochromocytoma Pc12 ◽  
Pheochromocytoma Pc12 Cells
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