The Target Animal Safety Test—Is it Still Relevant?

Biologicals ◽  
2002 ◽  
Vol 30 (4) ◽  
pp. 277-287
Keyword(s):  
Target Animal ◽  
Safety Test ◽  
Animal Safety

scholarly journals Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
L. DeTolla ◽  
R. Sanchez ◽  
E. Khan ◽  
B. Tyler ◽  
M. Guarnieri
Keyword(s):  
Clinical Pathology ◽  
Test System ◽  
Clinical Observations ◽  
Safety Test ◽  
Term Delivery ◽  
Low Toxicity ◽  
Animal Safety ◽  
Higher Doses ◽  
Drug Implants

Subcutaneous drug implants are convenient systems for the long-term delivery of drugs in animals. Lipid carriers are logical tools because they generally allow for higher doses and low toxicity. The present study used an US Food and Drug Administration Target Animal Safety test system to evaluate the safety of a subcutaneous implant of a cholesterol-triglyceride-buprenorphine powder in 120 BALB/c mice. Mice were evaluated in 4- and 12-day trials with 1- and 5-fold doses of the intended 3 mg/kg dose of drug. One male mouse treated with three 3 mg/kg doses and surgery on days 0, 4, and 8 died on day 9. The cause of death was not determined. In the surviving 119 mice there was no evidence of skin reaction at the site of the implant. Compared to control animals treated with saline, weight measurements, clinical pathology, histopathology, and clinical observations were unremarkable. These results demonstrate that the lipid carrier is substantially safe. Cholesterol-triglyceride-drug powders may provide a valuable research tool for studies of analgesic and inflammatory drug implants in veterinary medicine.

scholarly journals Target Animal Safety and Residual Study for Berberine and other Phytogenic Compounds in Broiler Chickens

2017 ◽  
Vol 08 (06) ◽  
Author(s):  
David Xiang Yu ◽  
Zhiyong He ◽  
Colin Pouton ◽  
Frederic J Hoerr ◽  
Zhi cheng Xiao
Keyword(s):  
Broiler Chickens ◽  
Target Animal ◽  
Animal Safety

Equine allogeneic chondrogenic induced mesenchymal stem cells: A GCP target animal safety and biodistribution study

2018 ◽  
Vol 117 ◽  
pp. 246-254 ◽  
Author(s):  
S.Y. Broeckx ◽  
J.H. Spaas ◽  
K. Chiers ◽  
L. Duchateau ◽  
L. Van Hecke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Biodistribution Study ◽  
Target Animal ◽  
Animal Safety

Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China

2019 ◽  
Vol 103 ◽  
pp. 21-33
Author(s):  
Zhen Dong ◽  
Jichao Sun ◽  
Yubin Bai ◽  
Weiwei Wang ◽  
Yueming Zhu ◽  
...  
Keyword(s):  
Safety Testing ◽  
Target Animal ◽  
Animal Safety

scholarly journals Erratum: N.P. Neugodova et al., Current approaches to the abnormal toxicity test

2020 ◽  
Vol 10 (3) ◽  
pp. 212
Author(s):  
Article Editorial
Keyword(s):  
Toxicity Test ◽  
Laboratory Animal ◽  
Expert Evaluation ◽  
Medicinal Products ◽  
Target Animal ◽  
Safety Test ◽  
Bottom Left ◽  
Human Use

Neugodova N.P., Stepanyuk E.O., Sapozhnikova G.A., Sakanyan E.I., Ryabtseva M.S. Current approaches to the abnormal toxicity test. Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primeneniya = The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2020;10(2):82–88. https://doi.org/10.30895/1991-2919-2020-10-2-82-88Dear readers, on page 84 (second paragraph from the bottom, left column) in issue 2 of The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, 2020 (2020;10(2):82–88) the following statement: “The discussions centered around suppression of the abnormal toxicity test and target animal batch safety test for vaccines for human use, and the possibility of suppression of the laboratory animal batch safety test for veterinary vaccines” should read: “The discussions centered around suppression of the abnormal toxicity test for vaccines for human use, and the possibility of suppression of the laboratory animal batch safety test and target animal batch safety test for veterinary vaccines”. 

scholarly journals Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats

Lab Animal ◽  
2015 ◽  
Vol 45 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Alan Cowan ◽  
Rachel Sarabia-Estrada ◽  
Gina Wilkerson ◽  
Patrick McKnight ◽  
Michael Guarnieri
Keyword(s):  
Adverse Effects ◽  
Extended Release ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Target Animal ◽  
Animal Safety
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