Cross-Contamination of Enrofloxacin in Veterinary Medicinal and Nutritional Products in Korea

Poultry meat and eggs are vital sources of protein for human consumption worldwide. The use of several nutritional and medicinal products, including antibiotics, is crucial for efficient and safe poultry production. Accumulation of drug residues in meat and eggs from inappropriate drug use is a major concern to public health. Recently, enrofloxacin was detected (2.4–3.8 ppb) in edible eggs produced in Jeju Island, Korea. Although the farm from which the enrofloxacin-contaminated eggs were collected did not use enrofloxacin-containing products, they reported extensive use of a nutritional product (NPJ). Accordingly, in this study, we investigated whether enrofloxacin contamination had occurred accidentally in various widely used veterinary pharmaceutical products. Enrofloxacin content (4.57–179.08 ppm) in different lots of the NPJ was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Furthermore, 76 veterinary pharmaceutical products that are widely used in poultry farms in Korea and claim to not contain enrofloxacin were collected and analyzed by LC-MS/MS. Among them, a florfenicol product and a sulfatrimethoprime product were found to contain 3.00 and 0.57 ppm enrofloxacin, respectively. These results suggest that appropriate manufacturing standards are not being followed and that strict monitoring of drug manufacturing is necessary in Korea to avoid drug contamination.

INSECT GROWTH REGULATORS IN CASE OF ENTOMOSIS OF DOGS AND CATS

The article presents the results of a study on the spread of insect growth regulators (IGRs) in dog and cat insecticide compositions. The major percentage of combined insecticacaricidal preparations in the veterinary pharmaceutical market contained the polycyclic juvenide pyriproxyfen - 43.5 % TN and the isoprenoid juvenide metoprene - 37.0%. The third most prevalent are herbal ecdysoids - preparations based on essential oil or margosa extract (syn. Neem, Melia) - 15,2 % of TN.

Legislative regulatory aspects of the veterinary pharmacy market in the European Union

Production of veterinary pharmacy plays an important role both in animal care and public health, such as for food safety or animal origin to prevent the spread of diseases transmitted to humans through animals. The European market for Animal Health develops rapidly filled with innovative products, updated regulatory system at the legislative level, in order to protect human health, animals and the environment. Today, the focus of attention in the European Union (EU) on the pharmaceutical industry – Is the improvement of the legal framework and its adaptation to the needs and characteristics of the veterinary pharmaceutical industry in particular. Thus Ukraine today - is an intensive process of harmonization, implementation and, at the same time, improvement of the regulatory system, in which international regulatory documents are the basis for the creation of the veterinary pharmaceutical legislation of Ukraine, according to EU requirements.