Activity and safety test combination of garlic exstract(Alium sativuml) and candlenut extract(Aleurites molucanna) as fertilizer rabbit fur

Efficacy of candlenut oil and garlic oil with three concentrations of 1000 ppm, 500 ppm and 100 ppm tested its activity as a fertilizer of rabbit fur by applying hazelnut oil and garlic oil each of approximately 1 ml at spot prepared twice daily for 28 days. The result of the third activity test of this concentration tested the data with statistics and got the most optimum result as a grower of rabbit fur is candlenuts oil with the concentration of 1000 ppm with the average growth of length for 28 days is 0,6250 cm and garlic oil with concentration 500 ppm with the average length of growth for 28 days is 0.8417 cm, while for the most optimum rabbit fur weights are with garlic concentration of 1000 ppm with an average weight of 28 days is 0.3627 g, while the growth of rabbit fur weight most optimum for 28 days is candlenut 1000 ppm with an average weight for 28 days = 0.3518 g result of significant analysis at (p≤0,05).

Investigation into the Lithium-Ion Battery Fire Resistance Testing Procedure for Commercial Use

Lithium-ion batteries (LIBs) have many advantages (e.g., high voltage and long-life cycle) in comparison to other energy storage technologies (e.g., lead acid), resulting in their applicability in a wide variety of structures. Simultaneously, the thermal stability of LIBs is relatively poor and can be damaged by exposure to fire. This paper presents an investigation into a fire resistance safety test for LIBs and the use of thermal sensors to evaluate exposure conditions and estimate the temperatures to which cells are subjected. Temperature distribution data and statistical analysis show significant differences of over 200 ∘C, indicating the stochastic nature of the heating curve despite following the testing procedure requirements. We concluded that the current testing procedure is inadequate for the reliable testing of LIBs, leaving an alarming loophole in the fire safety evaluation. The observed instability is mostly related to wind speed and direction, and fire source size.

Antielastase Activity of Macassar Kernels (Rhus javanica) Stem Extract and Skin Elasticity Evaluation of Its Topical Gel Formulation

Background. Macassar kernels (Rhus javanica L.) has potential as an antiaging agent as it has antielastase activity, especially its stem extract which has best percent inhibition compared to its leaves and fruit extract. Moreover, the antiaging agent can be commonly used in the form of gel for topical applications. Hence, formulation of HEC-based topical gel from the stem extract of Macassar kernels was conducted. This study aims to determine the antielastase activity of the stem extract of Macassar kernels and evaluate the skin elasticity of its topical gel formulation by conducting dermatological safety and skin antiaging efficacy test. Methods. The stem extract was in vitro tested for antielastase activity using a microplate reader. Then, a formulation of a topical gel containing Rhus javanica stem extract was made. Five stages of quality control, which consisted of an organoleptic test, homogeneity test, pH measurement, viscosity measurement, and physicochemical stability test, were conducted to ensure the quality of topical gel formulation. Last, clinical studies were conducted to evaluate the dermatological safety and antiaging efficacy of gel preparation containing stem extract of Rhus javanica. Results. The stem extract provided antielastase activity (IC50 = 245.68 μg/mL), and its polyphenol was valued at 23.28 ± 1.52 mg GAE/g). The gel containing 10% stem extract had better stability than the gel containing 5% stem extract. The dermatology safety test and efficacy test results indicated that the topical gel containing 10% Rhus javanica stem extract did not cause any skin irritation and significantly improved skin elasticity p < 0.05 . In the treatment group, the moisture parameter was significantly changed on day 14 p < 0.0001 , day 21 p < 0.0001 , and day 29 p < 0.0001 . The elasticity parameter was also changed significantly on day 14 p = 0.0485 , day 21 p = 0.0537 , and day 29 p = 0.0002 . Conclusion. The stem extract of Rhus javanica has potential antielastase activity. The topical gel containing Rhus javanica stem extract also has potential antielastase activity by increasing the skin moisture and enhancing skin elasticity.

The effectiveness of a nonalcoholic disinfectant containing metal ions, with broad antimicrobial activity

Disinfectants have different efficacies depending on their use and the target microorganism. This study aimed to evaluate the efficacy and safety of our new nonalcoholic disinfectant, which consists mainly of metal ions. According to the 17th revised Japanese Pharmacopoeia and ASTM international E1052 method, the bactericidal and virucidal efficacy of this new disinfectant against 13 microorganisms was evaluated by the in vitro quantitative suspension test. Additionally, the disinfectant cytotoxicity against multiple cell lines was examined. Then, a safety test using a human open patch test was performed with 26 healthy volunteers. This disinfectant showed strong bactericidal and virucidal activities: all microorganisms except enterovirus were inactivated very quickly. The infectivity of 12 microbial strains was eliminated within 5 min of disinfectant exposure. Additionally, this disinfectant showed little acute cytotoxicity in vitro. All volunteers were negative in the human open patch test. Our new disinfectant has a broad spectrum of microbial targets, is safe for human skin, and demonstrates no cytotoxicity. This disinfectant could prevent common microbial infections.

The Development and Piloting of the Ambulatory Electronic Health Record Evaluation Tool: Lessons Learned

Background Substantial research has been performed about the impact of computerized physician order entry on medication safety in the inpatient setting; however, relatively little has been done in ambulatory care, where most medications are prescribed. Objective To outline the development and piloting process of the Ambulatory Electronic Health Record (EHR) Evaluation Tool and to report the quantitative and qualitative results from the pilot. Methods The Ambulatory EHR Evaluation Tool closely mirrors the inpatient version of the tool, which is administered by The Leapfrog Group. The tool was piloted with seven clinics in the United States, each using a different EHR. The tool consists of a medication safety test and a medication reconciliation module. For the medication test, clinics entered test patients and associated test orders into their EHR and recorded any decision support they received. An overall percentage score of unsafe orders detected, and order category scores were provided to clinics. For the medication reconciliation module, clinics demonstrated how their EHR electronically detected discrepancies between two medication lists. Results For the medication safety test, the clinics correctly alerted on 54.6% of unsafe medication orders. Clinics scored highest in the drug allergy (100%) and drug–drug interaction (89.3%) categories. Lower scoring categories included drug age (39.3%) and therapeutic duplication (39.3%). None of the clinics alerted for the drug laboratory or drug monitoring orders. In the medication reconciliation module, three (42.8%) clinics had an EHR-based medication reconciliation function; however, only one of those clinics could demonstrate it during the pilot. Conclusion Clinics struggled in areas of advanced decision support such as drug age, drug laboratory, and drub monitoring. Most clinics did not have an EHR-based medication reconciliation function and this process was dependent on accessing patients' medication lists. Wider use of this tool could improve outpatient medication safety and can inform vendors about areas of improvement.

Pengujian Keselamatan Thermal pada Battery Pack Sepeda Motor Listrik Berdasarkan Regulasi UN R-136

The electric-motorcycle is one of the promising technology that can improve environmental quality as well as reduce dependency on oil imports in Indonesia. The major challenge of electric-motorcycle implementation is the safety of the lithium-ion battery pack. This research aims to ascertain the over-temperature protection, and also to carry out shock & cycling test for the battery thermal safety. The testing procedures and apparatus comply with the United Nations Regulation No 136 (UN R-136), namely a temperature humidity chamber, a battery load unit, a blower, and a charger. The first step is the designing and prototyping of the battery pack with 100 V and 30 Ah, which contains a module of cells, Battery Management System (BMS), wiring, isolator, socket, and aluminum casing. The second step is the battery thermal safety test. The results showed that the battery pack satisfied the acceptance criteria, with evidence of no electrolyte leakage, rupture, fire, and explosion during and after testing. Result of over-temperature protection, BMS can cut-off the discharge rate at a temperature of 45.89°C. Meanwhile, for thermal shock & cycling tests, the battery pack did not fail when the temperature changes from 59.72°C and -40.25°C for 60 hours.