scholarly journals The Sequence of Regulatory Events Controlling the Expression of the γD-crystallin Gene during Fibroblast Growth Factor-Mediated Rat Lens Fiber Cell Differentiation

1996 ◽  
Vol 173 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Ron P.H. Dirks ◽  
Erik Jan Klok ◽  
Siebe T. van Genesen ◽  
John G.G. Schoenmakers ◽  
Nicolette H. Lubsen
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fiber Cell ◽  
Fibroblast Growth ◽  
Lens Fiber ◽  
Lens Fiber Cell

scholarly journals Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation

2008 ◽  
Vol 318 (2) ◽  
pp. 276-288 ◽  
Author(s):  
Haotian Zhao ◽  
Tianyu Yang ◽  
Bhavani P. Madakashira ◽  
Cornelius A. Thiels ◽  
Chad A. Bechtle ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fiber Cell ◽  
Fibroblast Growth ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Growth Factor Receptor Signaling

scholarly journals Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten

2020 ◽  
Vol 467 (1-2) ◽  
pp. 1-13
Author(s):  
Stephanie L. Padula ◽  
Elaine P. Sidler ◽  
Brad D. Wagner ◽  
Courtney J. Manz ◽  
Frank J. Lovicu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fiber Cell ◽  
Fibroblast Growth ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Growth Factor Receptor Signaling

Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation

Development ◽  
2002 ◽  
Vol 129 (16) ◽  
pp. 3795-3802 ◽  
Author(s):  
Teri Louise Belecky-Adams ◽  
Ruben Adler ◽  
David C. Beebe
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Cell Elongation ◽  
Chicken Embryo ◽  
Vitreous Humor ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Fiber Cells ◽  
Bmp Receptors

Previous studies showed that the retina produces factors that promote the differentiation of lens fiber cells, and identified members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as potential fiber cell differentiation factors. A possible role for the bone morphogenetic proteins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses. We have now observed that phosphorylated SMAD1, an indicator of signaling through BMP receptors, localizes to the nuclei of elongating lens fiber cells. Transduction of chicken embryo retinas and/or lenses with constructs expressing noggin, a secreted protein that binds BMPs and prevents their interactions with their receptors, delayed lens fiber cell elongation and increased cell death in the lens epithelium. In an in vitro explant system, in which chicken embryo or adult bovine vitreous humor stimulates chicken embryo lens epithelial cells to elongate into fiber-like cells, these effects were inhibited by noggin-containing conditioned medium, or by recombinant noggin. BMP2, 4, or 7 were able to reverse the inhibition caused by noggin. Lens cell elongation in epithelial explants was stimulated by treatment with FGF1 or FGF2, alone or in combination with BMP2, but not to the same extent as vitreous humor. These data indicate that BMPs participate in the differentiation of lens fiber cells, along with at least one additional, and still unknown factor.

A New Avian Fibroblast Growth Factor Receptor in Myogenic and Chondrogenic Cell Differentiation

1994 ◽  
Vol 212 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Orna Halevy ◽  
Efrat Monsonego ◽  
Christophe Marcelle ◽  
Vyacheslave Hodik ◽  
Anahit Mett ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

pRb and p107 regulate E2F activity during lens fiber cell differentiation

Oncogene ◽  
1998 ◽  
Vol 16 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Anuradha M Rampalli ◽  
Chun Y Gao ◽  
Vijay M Chauthaiwale ◽  
Peggy S Zelenka
Keyword(s):  
Cell Differentiation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell
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