Environmental Exposure to Trace Elements and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case–Control Study

2002 ◽  
Vol 89 (2) ◽  
pp. 116-123 ◽  
Author(s):  
Margherita Bergomi ◽  
Marco Vinceti ◽  
Grazia Nacci ◽  
Vladimiro Pietrini ◽  
Peter Brätter ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Trace Elements ◽  
Environmental Exposure ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

2020 ◽  
Vol 17 (8) ◽  
pp. 2882 ◽  
Author(s):  
Tommaso Filippini ◽  
Marina Tesauro ◽  
Maria Fiore ◽  
Carlotta Malagoli ◽  
Michela Consonni ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Environmental Exposure ◽  
Case Control Study ◽  
Positive Association ◽  
Population Based ◽  
Case Control ◽  
Occupational Factors ◽  
Increased Risk ◽  
Control Study ◽  
Lateral Sclerosis

Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with still unknown etiology. We aimed at investigating the association between environmental and occupational factors with ALS risk. Methods: We performed a population-based case-control study in four Italian provinces (Catania, Modena, Novara, and Reggio Emilia) by administration of tailored questionnaires to ALS cases (n = 95) and randomly selected population referents (n = 135). We estimated ALS risk by calculating the odds ratio (OR) with its 95% confidence interval (CI) using an unconditional logistic regression model. Results: We found a positive association with disease risk for history of occupation in the agricultural sector (OR = 2.09, 95% CI 0.79–7.54), especially for longer than 10 years (OR = 2.72, 95% 1.02–7.20). Overall occupational exposure to solvents also suggested a positive association, especially for thinners (OR = 2.27, 95% CI 1.14–4.54) and paint removers (OR = 2.01, 95% CI 0.90–4.48). Both occupational and environmental exposure to electromagnetic fields show a slightly increased risk with OR = 1.69 (95% CI 0.70–4.09) and 2.41 (95% CI 1.13–5.12), respectively. Occupational but not environmental exposure to pesticides (OR = 1.22, 95% CI 0.63–2.37), particularly fungicides, and exposure to metals (OR = 4.20, 95% CI 1.88–9.38), particularly lead, mercury, and selenium, showed an imprecise but positive association. Finally, there was an indication of increased risk for living in proximity to water bodies. Conclusions: Despite the caution that needs to be used due to some study limitations, such as the low number of exposed subjects and the possibility of recall bias, these results suggest the potential role of some environmental and occupational factors in ALS etiology.

scholarly journals Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry

2012 ◽  
Vol 19 (12) ◽  
pp. 1509-1517 ◽  
Author(s):  
E. Pupillo ◽  
P. Messina ◽  
G. Logroscino ◽  
S. Zoccolella ◽  
A. Chiò ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Population Based Registry ◽  
Control Study ◽  
Lateral Sclerosis

Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case–control study

2015 ◽  
Vol 359 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Beatrice Bocca ◽  
Giovanni Forte ◽  
Riccardo Oggiano ◽  
Simonetta Clemente ◽  
Yolande Asara ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis

Physical activity and amyotrophic lateral sclerosis: A European population-based case-control study

2014 ◽  
Vol 75 (5) ◽  
pp. 708-716 ◽  
Author(s):  
Elisabetta Pupillo ◽  
Paolo Messina ◽  
Giorgia Giussani ◽  
Giancarlo Logroscino ◽  
Stefano Zoccolella ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
European Population ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

2020 ◽  
Vol 17 (3) ◽  
pp. 857 ◽  
Author(s):  
Tommaso Filippini ◽  
Maria Fiore ◽  
Marina Tesauro ◽  
Carlotta Malagoli ◽  
Michela Consonni ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Southern Italy ◽  
Population Based ◽  
Case Control ◽  
Lifestyle Factors ◽  
Inverse Association ◽  
Increased Risk ◽  
Control Study ◽  
Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease of the motor neurons. The etiology of ALS remains largely unknown, particularly with reference to the potential environmental determinants. Methods: We performed a population-based case-control study in four provinces from both Northern and Southern Italy in order to assess non-genetic ALS risk factors by collecting through tailored questionnaires information about clinical and lifestyle factors. We estimated ALS risk by calculating odds ratio (OR) with its 95% confidence interval (CI) using unconditional logistic regression models adjusted for sex, age and educational attainment. Results: We recruited 230 participants (95 cases and 135 controls). We found a possible positive association of ALS risk with trauma, particularly head trauma (OR = 2.61, 95% CI 1.19–5.72), electric shock (OR = 2.09, 95% CI 0.62–7.06), and some sports, although at a competitive level only. In addition, our results suggest an increased risk for subjects reporting use of private wells for drinking water (OR = 1.38, 95% CI 0.73–2.27) and for use of herbicides during gardening (OR = 1.95, 95% CI 0.88–2.27). Conversely, there was a suggestion of an inverse association with overall fish consumption (OR = 0.27, 95% CI 0.12–0.60), but with no dose-response relation. Consumption of some dietary supplements, namely those containing amino acids and, in the Southern Italy population, vitamins and minerals such as selenium, seemed associated with a statistically imprecise increased risk. Conclusions: Our results suggest a potential etiologic role a number of clinical and lifestyle factors with ALS risk. However, caution is needed due to some study limitations. These include the small sample size and the low number of exposed subjects, which affect statistical precision of risk estimates, the potential for exposure misclassification, and the uncertainties about mechanisms underpinning the possible association between these factors and disease risk.

scholarly journals Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case–control Study

2017 ◽  
Vol 125 (9) ◽  
pp. 097023 ◽  
Author(s):  
Meinie Seelen ◽  
Rosario A. Toro Campos ◽  
Jan H. Veldink ◽  
Anne E. Visser ◽  
Gerard Hoek ◽  
...  
Keyword(s):  
Air Pollution ◽  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Occupational Exposures and Amyotrophic Lateral Sclerosis. A Population-based Case-Control Study

1997 ◽  
Vol 145 (12) ◽  
pp. 1076-1088 ◽  
Author(s):  
V. McGuire ◽  
W. T. Longstreth ◽  
L. M. Nelson ◽  
T. D. Koepsell ◽  
H. Checkoway ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis
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