Protective Role of Nerve Growth Factor against Excitatory Amino Acid Injury during Neostriatal Cholinergic Neurons Postnatal Development

1995 ◽  
Vol 135 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Esther Pérez-Navarro ◽  
Jordi Alberch
Keyword(s):  
Amino Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Postnatal Development ◽  
Excitatory Amino Acid ◽  
Cholinergic Neurons ◽  
Protective Role ◽  
Nerve Growth

Role of nerve growth factor in plasticity of forebrain cholinergic neurons

2017 ◽  
Vol 82 (3) ◽  
pp. 291-300 ◽  
Author(s):  
N. K. Isaev ◽  
E. V. Stelmashook ◽  
E. E. Genrikhs
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cholinergic Neurons ◽  
Nerve Growth

Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation

Circulation ◽  
1997 ◽  
Vol 95 (1) ◽  
pp. 213-220 ◽  
Author(s):  
Toyohiko Abe ◽  
Donald A. Morgan ◽  
David D. Gutterman
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protective Role ◽  
Nerve Growth

scholarly journals The Role of Astrocytes in the Cause of Alzheimer's Disease

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Nadia Priyam ◽  
Andrew Savoy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cholinergic Neurons ◽  
Amyloid Plaques ◽  
Nerve Growth ◽  
App Processing ◽  
Cholinergic Signaling

There are three leading hypotheses about the cause of Alzheimer’s Disease (AD): the cholinergic theory, where there is a loss of cholinergic neurons; the amyloid hypothesis, where there is an abnormal buildup of amyloid plaques; and the neurotrophic unbalance hypothesis, which states that AD-related loss of cholinergic signaling and altered amyloid precursor protein (APP) processing are due to alterations in nerve growth factor (NGF). This would ultimately mean that the loss of cholinergic neurons and a buildup of amyloid plaques are due to NGF alterations. Astrocytes are involved in the production of amyloid-beta, inflammation responses, and nerve growth. Therefore, astrocytes are an essential component of all three AD hypotheses. This paper will discuss various known and hypothesized ways that astrocytes affect the symptoms and possible causes of AD.

Sign in / Sign up

Export Citation Format

Share Document