Overexpression of G Protein-Coupled Receptor Kinase-2 in Smooth Muscle Cells Reduces Neointimal Hyperplasia

2002 ◽  
Vol 34 (10) ◽  
pp. 1399-1409 ◽  
Author(s):  
Karsten Peppel ◽  
Lisheng Zhang ◽  
Tam T.T. Huynh ◽  
Xuewei Huang ◽  
Anne Jacobson ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Neointimal Hyperplasia ◽  
Muscle Cells ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells

2001 ◽  
Vol 29 (5) ◽  
pp. 325-329 ◽  
Author(s):  
Kenji Obara ◽  
Kei Arai ◽  
Yoshihiko Tomita ◽  
Akihiko Hatano ◽  
Kota Takahashi
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Muscle Cells ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Cultured Smooth Muscle Cells ◽  
G Protein Coupled ◽  
Human Detrusor

scholarly journals G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta

1997 ◽  
Vol 272 (51) ◽  
pp. 32482-32488 ◽  
Author(s):  
Nobukazu Ishizaka ◽  
R. Wayne Alexander ◽  
Jørn Bech Laursen ◽  
Hisashi Kai ◽  
Toshiki Fukui ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Rat Aorta ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Selective Regulation of H1Histamine Receptor Signaling by G Protein-Coupled Receptor Kinase 2 in Uterine Smooth Muscle Cells

2008 ◽  
Vol 22 (8) ◽  
pp. 1893-1907 ◽  
Author(s):  
Jonathon M. Willets ◽  
Anthony H. Taylor ◽  
Hayley Shaw ◽  
Justin C. Konje ◽  
R. A. John Challiss
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Muscle Cells ◽  
Receptor Signaling ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Uterine Smooth Muscle ◽  
G Protein Coupled

scholarly journals Selective Activation of Nuclear Phospholipase D-1 by G Protein–Coupled Receptor Agonists in Vascular Smooth Muscle Cells

2006 ◽  
Vol 99 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Stéphanie Gayral ◽  
Paul Déléris ◽  
Karine Laulagnier ◽  
Muriel Laffargue ◽  
Jean-Pierre Salles ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Vascular Smooth Muscle Cells ◽  
Phospholipase D ◽  
Muscle Cells ◽  
G Protein Coupled Receptor ◽  
Selective Activation ◽  
G Protein Coupled

scholarly journals Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs

2021 ◽  
Author(s):  
Petra Mermer ◽  
Jörg Strotmann ◽  
Wolfgang Kummer ◽  
Renate Paddenberg
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
G Protein ◽  
Olfactory Receptor ◽  
Muscle Cells ◽  
Striated Muscles ◽  
Pressure Regulation ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

AbstractThe olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) is a member of the G protein-coupled receptor family mediating olfactory chemosensation, but it is additionally expressed in other tissues. Olfr78 expressed in kidney participates in blood pressure regulation, and in prostate it plays a role in the development of cancer. We here screened many organs/tissues of transgenic mice co-expressing β-galactosidase with Olfr78. X-gal-positive cells were detectable in smooth muscle cells of numerous arterioles of striated muscles (heart ventricles and skeletal muscles of various embryological origin). In addition, in most organs where we found expression of Olfr78 mRNA, X-gal staining was restricted to smooth muscle cells of small blood vessels. The dominant expression of Olfr78 in arteriolar smooth muscle cells supports the concept of an important role in blood pressure regulation and suggests a participation in the fine tuning of blood supply especially of striated muscles. This should be considered when targeting Olfr78 in other contexts such as prostate cancer.

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