Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion

2002 ◽  
Vol 34 (11) ◽  
pp. 1549-1560 ◽  
Author(s):  
Philip Eaton ◽  
Neville Wright ◽  
David J. Hearse ◽  
Michael J. Shattock
Keyword(s):  
Cardiac Ischemia ◽  
Ischemia And Reperfusion ◽  
Glyceraldehyde Phosphate Dehydrogenase

scholarly journals Enhanced nitration of several mitochondrial proteins during cardiac ischemia and reperfusion injury

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Meiying Yang ◽  
Amadou K.S. Camara ◽  
Ashish K. Gadicherla ◽  
Bassam Wakim ◽  
Mohammed Aldakkak ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cardiac Ischemia ◽  
Mitochondrial Proteins ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

Cardioprotection and effects of melatonin administration on cardiac ischemia reperfusion: Insight from clinical studies.

2019 ◽  
Vol 2 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Alberto Dominguez-Rodriguez ◽  
Pedro Abreu-Gonzalez ◽  
Yundai Chen
Keyword(s):  
Ischemia Reperfusion ◽  
Clinical Applications ◽  
Cardiac Ischemia ◽  
Acute Ischemia ◽  
Ischemia And Reperfusion ◽  
Patient Benefit ◽  
Ischemia And Reperfusion Injury ◽  
Experimental Animal Models ◽  
Melatonin Administration ◽  
End Effectors

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality. Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of AMI for patient benefit has been disappointing. Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities. Melatonin is a pleiotropic molecule with several functions. Its potential to protect the heart against ischemia/reperfusion damage has attracted much attention, particularly in view of its possible clinical applications. In this brief overview, we discuss the possible clinical application of melatonin in human. 

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