The Generation of Localized Calcium Rises Mediated by Cell Adhesion Molecules and Their Role in Neuronal Growth Cone Motility

2000 ◽  
Vol 3 (5) ◽  
pp. 255-263 ◽  
Author(s):  
Dara J. Dunican ◽  
Patrick Doherty
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Growth Cone ◽  
Cell Adhesion Molecules ◽  
Neuronal Growth ◽  
Neuronal Growth Cone

Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes

Neuron ◽  
1992 ◽  
Vol 8 (5) ◽  
pp. 831-842 ◽  
Author(s):  
Julie R. Atashi ◽  
Stephan G. Klinz ◽  
Christine A. Ingraham ◽  
Wayne T. Matten ◽  
Melitta Schachner ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tyrosine Phosphorylation ◽  
Adhesion Molecules ◽  
Growth Cone ◽  
Cell Adhesion Molecules ◽  
Neural Cell ◽  
Nerve Growth ◽  
Neural Cell Adhesion Molecules ◽  
Neural Cell Adhesion ◽  
Nerve Growth Cone

scholarly journals Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3

2005 ◽  
Vol 170 (7) ◽  
pp. 1159-1167 ◽  
Author(s):  
Noriko Ooashi ◽  
Akira Futatsugi ◽  
Fumie Yoshihara ◽  
Katsuhiko Mikoshiba ◽  
Hiroyuki Kamiguchi
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Ryanodine Receptor ◽  
Growth Cone ◽  
Cell Adhesion Molecules ◽  
Growth Cones ◽  
Receptor Type ◽  
Guidance Cues ◽  
Ganglion Neurons ◽  
Type 3

Axonal growth cones migrate along the correct paths during development, not only directed by guidance cues but also contacted by local environment via cell adhesion molecules (CAMs). Asymmetric Ca2+ elevations in the growth cone cytosol induce both attractive and repulsive turning in response to the guidance cues (Zheng, J.Q. 2000. Nature. 403:89–93; Henley, J.R., K.H. Huang, D. Wang, and M.M. Poo. 2004. Neuron. 44:909–916). Here, we show that CAMs regulate the activity of ryanodine receptor type 3 (RyR3) via cAMP and protein kinase A in dorsal root ganglion neurons. The activated RyR3 mediates Ca2+-induced Ca2+ release (CICR) into the cytosol, leading to attractive turning of the growth cone. In contrast, the growth cone exhibits repulsion when Ca2+ signals are not accompanied by RyR3-mediated CICR. We also propose that the source of Ca2+ influx, rather than its amplitude or the baseline Ca2+ level, is the primary determinant of the turning direction. In this way, axon-guiding and CAM-derived signals are integrated by RyR3, which serves as a key regulator of growth cone navigation.

Cell Adhesion Molecules: Selectins and Integrins

1999 ◽  
Vol 19 (5-6) ◽  
pp. 41 ◽  
Author(s):  
Francisco Sanchez-Madrid ◽  
Roberto González-Amaro
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules
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