In Vitro Transformation of Thiazopyr by Rat Liver Enzymes: Sulfur and Carbon Oxidations by Microsomes

1994 ◽  
Vol 48 (1) ◽  
pp. 8-14 ◽  
Author(s):  
P.C.C. Feng ◽  
R.T. Solsten ◽  
R.H. Mcclanahan
Keyword(s):  
Rat Liver ◽  
Liver Enzymes ◽  
In Vitro Transformation

Biotransformation of Some 2-Methylpapaverinium Derivatives with Rat Liver Enzymes in Vitro

Heterocycles ◽  
1979 ◽  
Vol 12 (2) ◽  
pp. 247 ◽  
Author(s):  
Dana Walterová ◽  
Alice Nemecková ◽  
Vilím Simánek ◽  
Ladislav Dolejs ◽  
Vladimír Preininger
Keyword(s):  
Rat Liver ◽  
Liver Enzymes

In vitro transformation induces abnormal protein thiol levels in rat liver cells

1990 ◽  
Vol 11 (8) ◽  
pp. 1429-1432 ◽  
Author(s):  
P. Principe ◽  
G.D. Wilson ◽  
P.A. Riley ◽  
T.F. Slater
Keyword(s):  
Rat Liver ◽  
Liver Cells ◽  
Protein Thiol ◽  
Abnormal Protein ◽  
In Vitro Transformation ◽  
Rat Liver Cells

In vitro techniques for studies on pituitary regulation of rat liver enzymes

1977 ◽  
Vol 8 (5) ◽  
pp. 603-607 ◽  
Author(s):  
Åke Stenberg ◽  
Peter Eneroth ◽  
Jan-Åke Gustafsson ◽  
Paul Skett
Keyword(s):  
Rat Liver ◽  
Liver Enzymes ◽  
In Vitro Techniques

scholarly journals Comparative Studies in vivo and in vitro of Rat-Liver Enzymes

1974 ◽  
Vol 44 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Matilde Salinas ◽  
Ruth Wallace ◽  
Santiago Grisolia
Keyword(s):  
Rat Liver ◽  
Comparative Studies ◽  
Liver Enzymes

Characterization of oxidative and reductive metabolism in vitro of nitrofluoranthenes by rat liver enzymes

1990 ◽  
Vol 11 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Maria Antonietta Belisario ◽  
Rita Pecce ◽  
Rossella Della Morte ◽  
Amalia R. Arena ◽  
Angelo Cecinato ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Enzymes ◽  
Reductive Metabolism

Pseudobase formation in 2-methylpapaverinium cations and their biotransformation by enzymes of rat liver homogenates in vitro

1980 ◽  
Vol 45 (3) ◽  
pp. 956-965 ◽  
Author(s):  
Daniela Walterová ◽  
Vladimír Preininger ◽  
Ladislav Dolejš ◽  
František Grambal ◽  
Miroslav Kyselý ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Aqueous Medium ◽  
Rat Liver ◽  
Carbonyl Compounds ◽  
Liver Enzymes ◽  
Aqueous Ethanol ◽  
Equilibrium Constants ◽  
Liver Homogenates

2-Methylpapaverinium iodide (I), 2'-hydroxymethyl-2-methylpapaverinium iodide (IX), and 2-methyl-3,4-dihydropapaverinium iodide (X. CH3I) form pseudobase by addition of hydroxide ions to the C(1)=N(+) bond. 2'-Hydroxymethyl-2-methyl-3,4-dihydropapaverinium iodide (XV) and 2'-hydroxymethyl-2-methyl-9-oxo-3,4-dihydropapaverinium iodide (XVI) react with hydroxide ions in aqueous medium under formation of cyclic pseudobases XVII and XVIII. The equilibrium constants (KR+) of pseudobase formation have been measured in aqueous ethanol (1 : 1 w/w, 25°C, ionic strength 0.1). The quaternary papaverinium derivatives are metabolized to isoquinilones and carbonyl compounds by means of rat liver enzymes. The role of pseudobases in these biotransformations has been discussed and biogenetic conclusions have been drawn.

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